Max Planck Institute for Multidisciplinary Sciences

Publications

Journal Article (646)

Journal Article

Hensel, T. A.; Schwarz, O. L.; Karrasch, T.; Göpfrich, K.; Hell, S. W.: Uninterrupted optical resolution of identical point scatterers undergoing nanometric changes in distance. Proceedings of the National Academy of Sciences of the United States of America 123, 29 (2026)

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Rembe, C.; Adams, J.; Belov, V. N.; Egner, A.; Eitzeroth, A.; Geisler, C.; Hercht, H.; Jain, P.; Li, Y.; Nagorny, S. et al.; Plieth, M.; Schmidt, A.; Weingartz, T.; Zhang, J.: Nanoscopy on composite materials with thin photochromic layers. tm - Technisches Messen (2026)

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Nguyễn, V. T.; Koenen, T.; Bucevičius, J.; Lukinavičius, G.: A Highly Selective, Cell-Permeable Fluorescent Probe for Imaging Histone Deacetylase 6 in Live Cells. Journal of the American Chemical Society 148 (24), pp. 24637 - 24645 (2026)

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Savicheva, E. A.; Hubrich, J.; Khan, T. A.; Bossi, M. L.; Belov, V. N.; Ackermann, L.; Hell, S. W.: Phenoxazines with a Phototransferable N-Acetyl Group and Acrylate Linker: Assembly by C–H Activation, Photoconversion to Fluorescent Dyes, Biolabeling, and Super-Resolution Imaging. Journal of the American Chemical Society 148 (23), pp. 24345 - 24356 (2026)

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Müller, J. P.; Belov, V. N.; Yamoune, S.; Miller, B.; Hasoumi, M.; Tupiec, J.; Laurentius, T.; Bollheimer, L. C.; Stingl, J. C.; Just, K. S.: Evaluation of a pantoprazole and 4‐desmethylpantoprazole‐sulfate metabolic ratio as a novel CYP2C19 phenotyping method. British Journal of Clinical Pharmacology (2026)

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Goel, R.; Jevdokimenko, K.; Rehm, R.; Hentze, J.; Agüi-Gonzalez, P.; Ninov, M.; Maier, E.; Wu, Y.; Lange, F.; Witkowska, A. et al.; Bolz, S.; Pennacchietti, F.; Damenti, M.; Kaempf, N.; Khayenko, V.; Calatayud, C.; Malviya, V. N.; Chanaday, N. L.; Hutchinson, E. S.; Liu, H.; Weyand, K.; Schwarze, V.; Ivanova, D.; Wallis, T. P.; Small, C.; Maric, H. M.; Joensuu, M.; Cousin, M. A.; Meunier, F. A.; Verstreken, P.; Testa, I.; Kavalali, E. T.; Haucke, V.; Jakobs, S.; Urlaub, H.; Brose, N.; Cooper, B. H.; Stenmark, P.; Opazo, F.; Jahn, R.; Rizzoli, S. O.; Fornasiero, E. F.: A versatile nanobody platform for live and super-resolution imaging of synaptic vesicle dynamics and plasticity in rodent and human neurons. Journal of Nanobiotechnology 24, 443 (2026)

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Lincoln, R.; Butkevich, A. N.; Gürth, C.-M.; Fischer, A.; Matthias, J.; Emmerich, A. R.; Fidlin, M.; Bossi, M. L.; Hell, S. W.: Caging-group-free photoactivatable fluorophores with far-red emission. Chem 12 (5), 102866 (2026)

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Brinker, T.; Günther, A.; Kiszka, K. A.; Rhee, J. S.; Gregor, C.: Labeling and imaging of neurons with a genetically encoded autonomous bioluminescence system. Scientific Reports 16 (1), 12892 (2026)

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Bösking, T.; Schwarz, D.; Aßenmacher, D.; Fiukowski, O.; Pohl, M.; Pauls, M.; Bannwarth, C.; Kolarski, D.; Hecht, S.: Light-driven reversible ring contraction and expansion to modulate strain, conformation, and reactivity. Chem 12 (4), 102947 (2026)

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Khan, T. A.; Bossi, M. L.; Fischer, A.; Belov, V. N.; Hell, S. W.: Photoactivatable Carborhodol and Carborhodamine Dyes with One Cleavable Group: Synthesis, Spectra, and Fluorescence Nanoscopy Applications. JACS Au 6 (3), pp. 1693 - 1701 (2026)

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Zink, A.; Dai, D.-F.; Wittich, A.; Henke, M.-T.; Pedrotti, G.; Heiduschka, S.; Santamaria, G.; Pentimalli, T. M.; Brueser, C.; Notopoulou, S. et al.; Umar, A. R.; Zhaivoron, A.; Petersilie, L.; Jerred, C.; Bergmans, J.; Neu, L. A.; Schumacher, F.; Keller-Findeisen, J.; Rybak-Wolf, A.; Stach, D.; Reinshagen, J.; Haferkamp, U.; Krieg, K.; Zaliani, A.; Euro, L.; Di Donfrancesco, A.; Santanatoglia, C.; Cappellozza, E.; Suarez Cubero, M.; Pavez-Giani, M.; Bakumenko, O.; Meierhofer, D.; Foley, A.; Morales-Gonzalez, S.; Tolle, I.; Herebian, D.; Bonesso, D.; Cecchetto, G.; Wong, S. N.; Moresco, M.; Maresca, A.; Decimo, I.; De Sanctis, F.; Adamo, A.; Adjobo-Hermans, M. J.W.; Duchi, R.; Barandalla, M.; Scaglia, M.; Perota, A.; Galli, C.; Kleuser, B.; Cyganek, L.; Mühlhausen, C.; Schlotawa, L.; Tiranti, V.; Mayatepek, E.; Szabo, I.; La Morgia, C.; Klopstock, T.; Carelli, V.; Distelmaier, F.; Rossi, A.; Rajewsky, N.; Ullah, G.; Jakobs, S.; Rose, C. R.; Petrakis, S.; Edenhofer, F.; Koopman, W. J.H.; Lisowski, P.; Suomalainen, A.; Brunetti, D.; del Sol, A.; Bottani, E.; Pless, O.; Schuelke, M.; Prigione, A.: Pluripotent stem-cell-based screening uncovers sildenafil as a mitochondrial disease therapy. Cell 189, pp. 1656 - 1679.e42 (2026)

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Butkevich, A. N.; Bossi, M. L.; Hubrich, J.; Hell, S. W.: Synthesis of Benzo[b]thiophene 1,1-Dioxides via Pd-Catalyzed Sulfinylation of Aryl Triflates and Their Use as Large Stokes Shift Fluorophores for Multicolor Live-Cell Imaging with Self-Labeling Tags. JACS Au 6 (4), pp. 2396 - 2406 (2026)

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Marten, L.M.; Lüttgens, M.S.; Berečić, B.; Tiburcy, M.; Brüser, C.; Gupta, S.; Jakobs, S.; Ammer, E.; Ohlenbusch, A.; Krätzner, R. et al.; Rosewich, H.; Gärtner, J.: Mitochondrial dysfunction and impaired oxidative stress defense as potential trigger of cerebral X-linked adrenoleukodystrophy. Free Radical Biology and Medicine 242, pp. 654 - 666 (2026)

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Uno, K.; Nagorny, S.; Aktalay, A.; Kim, D.; Bossi, M. L.; Belov, V. N.; Hell, S. W.: Fluorescent Diarylethenes With Polar Groups: Synthesis, Spectra, and Optical Microscopy Applications. Chemistry - A European Journal (2025)

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Belov, V. N.; Golz, C.: Uniform Preparation of (4R)- and (4S)-Fluoro-l-lysines from One Precursor: Retrosynthesis Software Approach and the Route of a Chemist. The Journal of Organic Chemistry 90 (49), pp. 17478 - 17490 (2025)

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Auvray, M.; Koenen, T.; Dybkov, O.; Urlaub, H.; Lukinavičius, G.: Biocompatible sulfonium-based covalent probes for endogenous tubulin fluorescence nanoscopy in live and fixed cells. Nature Communications 16, 11107 (2025)

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Last, M. G.F.; van Klaveren, M.; Janssen, L.; Jensen, N. A.; Jansen, I.; Jakobs, S.; Voortman, L. M.; Sharp, T. H.: Dual-colour super-resolution cryoCLEM in mammalian cells using the fluorescent proteins rsTagRFP and rsEGFP2. Journal of Structural Biology 217 (4), 108267 (2025)

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Stumpf, D.; Jensen, N. A.; Mittelheisser, C.; Keller-Findeisen, J.; Chizhik, A. I.; Kamper, M.; Diekmann, T.; Habenstein, F.; Jansen, I.; Enderlein, J. et al.; Sliwa, M.; Inamdar, K.; Hell, S. W.; Jakobs, S.: The near-infrared bacteriophytochrome-derived fluorescent protein PENELOPE enables RESOLFT superresolution microscopy. Proceedings of the National Academy of Sciences of the United States of America 122 (48), e2504748122 (2025)

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Reshetniak, S.; Bogaciu, C. A.; Bonn, S.; Brose, N.; Cooper, B. H.; D'Este, E.; Fauth, M.; Fernández‐Busnadiego, R.; Fiosins, M.; Fischer, A. et al.; Georgiev, S. V.; Jakobs, S.; Klumpp, S.; Köster, S.; Lange, F.; Lipstein, N.; Macarrón‐Palacios, V.; Milovanovic, D.; Moser, T.; Müller, M.; Opazo, F.; Outeiro, T. F.; Pape, C.; Priesemann, V.; Rehling, P.; Salditt, T.; Schlüter, O.; Simeth, N.; Steinem, C.; Tchumatchenko, T.; Tetzlaff, C.; Tirard, M.; Urlaub, H.; Wichmann, C.; Wolf, F.; Rizzoli, S. O.: The synaptic vesicle cluster as a controller of pre‐ and postsynaptic structure and function. The Journal of Physiology 603 (20), pp. 5935 - 5964 (2025)

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Mitronova, G. Y.; Quentin, C.; Belov, V. N.; Kiszka, K. A.; Wegener, J. W.; Lehnart, S. E.: Multitargeted Caffeic Acid Derivatives Inhibit Cardiac RyR2- and Na_V1.5- Channels but Stimulate SERCA2a Pump Activity. ACS Omega 10 (38), pp. 43831 - 43854 (2025)

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Knorr, G.; Bossi, M. L.; Hell, S. W.: On‐Target Photoassembly of Pyronin Dyes for Super‐Resolution Microscopy. Angewandte Chemie International Edition (2025)

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Kolarski, D.; Bossi, M. L.; Lincoln, R.; Fuentes-Monteverde, J. C.; Belov, V. N.; Hell, S. W.: Supramolecular Complexation of Quenched Rosamines with Cucurbit[7]Uril: Fluorescence Turn-ON Effect for Super-Resolution Imaging. Journal of the American Chemical Society 147 (32), pp. 28893 - 28902 (2025)

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Cruz-Zaragoza, L. D.; Dahal, D.; Koschel, M.; Boshnakovska, A.; Zheenbekova, A.; Yilmaz, M.; Morgenstern, M.; Dohrke, J.-N.; Bender, J.; Valpadashi, A. et al.; Henningfeld, K. A.; Oeljeklaus, S.; Kremer, L. S.; Breuer, M.; Urbach, O.; Dennerlein, S.; Lidschreiber, M.; Jakobs, S.; Warscheid, B.; Rehling, P.: Silencing mitochondrial gene expression in living cells. Science 389 (6759), 477 (2025)

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Stoldt, S.; Maass, F.; Weber, M.; Dennerlein, S.; Ilgen, P.; Gärtner, J.; Canfes, A.; Schweighofer, S. V.; Jans, D. C.; Rehling, P. et al.; Jakobs, S.: Super-resolution microscopy of mitochondrial mRNAs. Nature Communications 16, 6391 (2025)

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Kiszka, K. A.; Dullin, C.; Steffens, H.; Koenen, T.; Rothermel, E.; Alves, F.; Gregor, C.: Autonomous bioluminescence emission from transgenic mice. Science Advances 11 (28), eads0463 (2025)

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Preminger, N.; Zucker, B.; Hassdenteufel, S.; Stephan, T.; Jakobs, S.; Kozlov, M. M.; Schuldiner, M.: A data-driven model for mitochondrial inner membrane remodeling as a driving force of organelle shaping. Journal of Cell Science 138 (12), jcs263850 (2025)

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Kolarski, D.; Szymanski, W.; Feringa, B. L.: Spatiotemporal Control Over Circadian Rhythms With Light. Medicinal Research Reviews 45 (3), pp. 968 - 984 (2025)

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Lange, F.; Ratz, M.; Dohrke, J.-N.; Le Vasseur, M.; Wenzel, D.; Ilgen, P.; Riedel, D.; Jakobs, S.: In situ architecture of the human prohibitin complex. Nature Cell Biology 27, pp. 633 - 640 (2025)

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Hensel, T. A.; Wirth, J. O.; Schwarz, O. L.; Hell, S. W.: Diffraction minima resolve point scatterers at few hundredths of the wavelength. Nature Physics 21, pp. 412 - 420 (2025)

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Macarrón-Palacios, V.; Hubrich, J.; do Rego Barros Fernandes Lima, M. A.; Metzendorf, N. G.; Kneilmann, S.; Trapp, M.; Acuna, C.; Patrizi, A.; D’Este, E.; Kilimann, M. W.: Paralemmin-1 controls the nanoarchitecture of the neuronal submembrane cytoskeleton. Science Advances 11 (10), eadt3724 (2025)

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Savchenko, A. I.; Belov, V. N.; Bossi, M. L.; Hell, S. W.: Asymmetric Donor–Acceptor 2,7-Disubstituted Fluorenes and Their 9-Diazoderivatives: Synthesis, Optical Spectra and Photolysis. Molecules 30 (2), 321 (2025)

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Saller, B. S.; Wöhrle, S.; Fischer, L.; Dufossez, C.; Ingerl, I. L.; Kessler, S.; Mateo-Tortola, M.; Gorka, O.; Lange, F.; Cheng, Y. et al.; Neuwirt, E.; Marada, A.; Koentges, C.; Urban, C.; Aktories, P.; Reuther, P.; Giese, S.; Kirschnek, S.; Mayer, C.; Pilic, J.; Falquez-Medina, H.; Oelgeklaus, A.; Deepagan, V. G.; Shojaee, F.; Zimmermann, J. A.; Weber, D.; Tai, Y.-H.; Crois, A.; Ciminski, K.; Peyronnet, R.; Brandenburg, K. S.; Wu, G.; Baumeister, R.; Heimbucher, T.; Rizzi, M.; Riedel, D.; Helmstädter, M.; Buescher, J.; Neumann, K.; Misgeld, T.; Kerschensteiner, M.; Walentek, P.; Kreutz, C.; Maurer, U.; Rambold, A. S.; Vince, J. E.; Edlich, F.; Malli, R.; Häcker, G.; Kierdorf, K.; Meisinger, C.; Köttgen, A.; Jakobs, S.; Weber, A. N.R.; Schwemmle, M.; Groß, C. J.; Groß, O.: Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation. Immunity 58 (1), pp. 90 - 107.e11 (2025)

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Van Haute, L.; Páleníková , P.; Tang, J. X.; Nash, P. A.; Simon, M. T.; Pyle, A.; Oláhová, M.; Powell, C. A.; Rebelo-Guiomar, P.; Stover, A. et al.; Champion, M.; Deshpande, C.; Baple, E. L.; Stals, K. L.; Ellard, S.; Anselem, O.; Molac, C.; Petrilli, G.; Loeuillet, L.; Grotto, S.; Attie-Bitach, T.; Abdenur, J. E.; Taylor, R. W.; Minczuk, M.: Pathogenic PDE12 variants impair mitochondrial RNA processing causing neonatal mitochondrial disease. Embo Molecular Medicine 17 (1), pp. 193 - 210 (2025)

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Elancheliyan, P.; Maruszczak, K. K.; Serwa, R. A.; Stephan, T.; Gulgec, A. S.; Borrero-Landazabal, M. A.; Ngati, S.; Gosk, A.; Jakobs, S.; Wasilewski, M. et al.; Chacinska, A.: OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase. Cell Reports 43 (12), 115038 (2024)

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Moosmayer, T.; Kiszka, K. A.; Westphal, V.; Pape, J. K.; Leutenegger, M.; Steffens, H.; Grant, S.G.N.; Sahl, S. J.; Hell, S. W.: MINFLUX fluorescence nanoscopy in biological tissue. Proceedings of the National Academy of Sciences of the United States of America 121 (52), e2422020121 (2024)

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Scholz, J.; Stephan, T.; Pérez, A. G.; Csiszár, A.; Hersch, N.; Fischer, L. S.; Brühmann, S.; Körber, S.; Litschko, C.; Mijanovic, L. et al.; Kaufmann, T.; Lange, F.; Springer, R.; Pich, A.; Jakobs, S.; Peckham, M.; Tarantola, M.; Grashoff, C.; Merkel, R.; Faix, J.: Decisive role of mDia-family formins in cell cortex function of highly adherent cells. Science Advances 10 (44), eadp5929 (2024)

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Sahl, S. J.; Matthias, J.; Inamdar, K.; Weber, M.; Khan, T. A.; Brüser, C.; Jakobs, S.; Becker, S.; Griesinger, C.; Broichhagen, J. et al.; Hell, S. W.: Direct optical measurement of intramolecular distances with angstrom precision. Science 386 (6718), pp. 180 - 187 (2024)

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Van den Eynde, R.; Hertel, F.; Abakumov, S.; Krajnik, B.; Hugelier, S.; Auer, A.; Hellmeier, J.; Schlichthaerle, T.; Grattan, R. M.; Lidke, D. S. et al.; Jungmann, R.; Leutenegger, M.; Vandenberg, W.; Dedecker, P.: Simultaneous multicolor fluorescence imaging using PSF splitting. Nature Methods 21, pp. 1801 - 1805 (2024)

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Remmel, M.; Matthias, J.; Lincoln, R.; Keller‐Findeisen, J.; Butkevich, A. N.; Bossi, M. L.; Hell, S. W.: Photoactivatable Xanthone (PaX) Dyes Enable Quantitative, Dual Color, and Live-Cell MINFLUX Nanoscopy. Small Methods 8 (9), 2301497 (2024)

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Schleske, J. M.; Hubrich, J.; Wirth, J. O.; D’Este, E.; Engelhardt, J.; Hell, S. W.: MINFLUX reveals dynein stepping in live neurons. Proceedings of the National Academy of Sciences of the United States of America 121 (38), e2412241121 (2024)

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Naas, J.; Nies, G.; Li, H.; Stoldt, S.; Schmitzer, B.; Jakobs, S.; Munk, A.: MultiMatch: geometry-informed colocalization in multi-color super-resolution microscopy. Communications Biology 7, 1139 (2024)

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Stephan, T.; Ilgen, P.; Jakobs, S.: Visualizing mitochondrial dynamics at the nanoscale. Light: Science & Applications 13, 244 (2024)

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Kim, D.; Bossi, M. L.; Belov, V. N.; Hell, S. W.: Supramolecular Complex of Cucurbit[7]uril with Diketopyrrolopyrole Dye: Fluorescence Boost, Biolabeling and Optical Microscopy. Angewandte Chemie International Edition 63 (36), e202410217 (2024)

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Bredfeldt, J.-E.; Oracz, J.; Kiszka, K. A.; Moosmayer, T.; Weber, M.; Sahl, S. J.; Hell, S. W.: Bleaching protection and axial sectioning in fluorescence nanoscopy through two-photon activation at 515 nm. Nature Communications 15, 7472 (2024)

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Aich, A.; Boshnakovska, A.; Witte, S.; Gall, T.; Unthan-Fechner, K.; Yousefi, R.; Chowdhury, A.; Dahal, D.; Methi, A.; Kaufmann, S. et al.; Silbern, I.; Prochazka, J.; Nichtova, Z.; Palkova, M.; Raishbrook, M.; Koubkova, G.; Sedlacek, R.; Tröder, S.E.; Zevnik, B.; Riedel, D.; Michanski, S.; Möbius, W.; Ströbel, P.; Lüchtenborg, C.; Giavalisco, P.; Urlaub, H.; Fischer, A.; Brügger, B.; Jakobs, S.; Rehling, P.: Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver. Nature Communications 15, 6914 (2024)

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Lukinavičius, G.; Alvelid, J.; Gerasimaitė, R.; Rodilla-Ramirez, C.; Nguyễn, V. T.; Vicidomini, G.; Bottanelli, F.; Han, K. Y.; Testa, I.: Stimulated emission depletion microscopy. Nature Reviews Methods primers 4 (1), 56 (2024)

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DʼEste, E.; Lukinavičius, G.; Lincoln, R.; Opazo, F.; Fornasiero, E.F.: Advancing cell biology with nanoscale fluorescence imaging: essential practical considerations. Trends in Cell Biology 34 (8), pp. 671 - 684 (2024)

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Khan, T. A.; Stoldt, S.; Bossi, M. L.; Belov, V. N.; Hell, S. W.: β-Galactosidase- and Photo-Activatable Fluorescent Probes for Protein Labeling and Super-Resolution STED Microscopy in Living Cells. Molecules 29, 3596 (2024)

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Proksch, K.; Werner, F.; Keller-Findeisen, J.; Ta, H.; Munk, A.: Toward quantitative super-resolution microscopy: molecular maps with statistical guarantees. Microscopy 73 (3), pp. 287 - 300 (2024)

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Wirth, J. O.; Schentarra, E.-M.; Scheiderer, L.; Macarrón-Palacios, V.; Tarnawski, M.; Hell, S. W.: Uncovering kinesin dynamics in neurites with MINFLUX. Communications Biology 7, 661 (2024)

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