Publications

Journal Article

Kolarski, D.; Szymanski, W.; Feringa, B. L.: Spatiotemporal Control Over Circadian Rhythms With Light. Medicinal Research Reviews 45 (3), pp. 968 - 984 (2025)

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Lange, F.; Ratz, M.; Dohrke, J.-N.; Le Vasseur, M.; Wenzel, D.; Ilgen, P.; Riedel, D.; Jakobs, S.: In situ architecture of the human prohibitin complex. Nature Cell Biology 27, pp. 633 - 640 (2025)

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Hensel, T. A.; Wirth, J. O.; Schwarz, O. L.; Hell, S. W.: Diffraction minima resolve point scatterers at few hundredths of the wavelength. Nature Physics 21, pp. 412 - 420 (2025)

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Macarrón-Palacios, V.; Hubrich, J.; do Rego Barros Fernandes Lima, M. A.; Metzendorf, N. G.; Kneilmann, S.; Trapp, M.; Acuna, C.; Patrizi, A.; D’Este, E.; Kilimann, M. W.: Paralemmin-1 controls the nanoarchitecture of the neuronal submembrane cytoskeleton. Science Advances 11 (10), eadt3724 (2025)

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Savchenko, A. I.; Belov, V. N.; Bossi, M. L.; Hell, S. W.: Asymmetric Donor–Acceptor 2,7-Disubstituted Fluorenes and Their 9-Diazoderivatives: Synthesis, Optical Spectra and Photolysis. Molecules 30 (2), 321 (2025)

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Saller, B. S.; Wöhrle, S.; Fischer, L.; Dufossez, C.; Ingerl, I. L.; Kessler, S.; Mateo-Tortola, M.; Gorka, O.; Lange, F.; Cheng, Y. et al.; Neuwirt, E.; Marada, A.; Koentges, C.; Urban, C.; Aktories, P.; Reuther, P.; Giese, S.; Kirschnek, S.; Mayer, C.; Pilic, J.; Falquez-Medina, H.; Oelgeklaus, A.; Deepagan, V. G.; Shojaee, F.; Zimmermann, J. A.; Weber, D.; Tai, Y.-H.; Crois, A.; Ciminski, K.; Peyronnet, R.; Brandenburg, K. S.; Wu, G.; Baumeister, R.; Heimbucher, T.; Rizzi, M.; Riedel, D.; Helmstädter, M.; Buescher, J.; Neumann, K.; Misgeld, T.; Kerschensteiner, M.; Walentek, P.; Kreutz, C.; Maurer, U.; Rambold, A. S.; Vince, J. E.; Edlich, F.; Malli, R.; Häcker, G.; Kierdorf, K.; Meisinger, C.; Köttgen, A.; Jakobs, S.; Weber, A. N.R.; Schwemmle, M.; Groß, C. J.; Groß, O.: Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation. Immunity 58 (1), pp. 90 - 107.e11 (2025)

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Van Haute, L.; Páleníková , P.; Tang, J. X.; Nash, P. A.; Simon, M. T.; Pyle, A.; Oláhová, M.; Powell, C. A.; Rebelo-Guiomar, P.; Stover, A. et al.; Champion, M.; Deshpande, C.; Baple, E. L.; Stals, K. L.; Ellard, S.; Anselem, O.; Molac, C.; Petrilli, G.; Loeuillet, L.; Grotto, S.; Attie-Bitach, T.; Abdenur, J. E.; Taylor, R. W.; Minczuk, M.: Pathogenic PDE12 variants impair mitochondrial RNA processing causing neonatal mitochondrial disease. Embo Molecular Medicine 17 (1), pp. 193 - 210 (2025)

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Elancheliyan, P.; Maruszczak, K. K.; Serwa, R. A.; Stephan, T.; Gulgec, A. S.; Borrero-Landazabal, M. A.; Ngati, S.; Gosk, A.; Jakobs, S.; Wasilewski, M. et al.; Chacinska, A.: OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase. Cell Reports 43 (12), 115038 (2024)

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Moosmayer, T.; Kiszka, K. A.; Westphal, V.; Pape, J. K.; Leutenegger, M.; Steffens, H.; Grant, S.G.N.; Sahl, S. J.; Hell, S. W.: MINFLUX fluorescence nanoscopy in biological tissue. Proceedings of the National Academy of Sciences of the United States of America 121 (52), e2422020121 (2024)

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Scholz, J.; Stephan, T.; Pérez, A. G.; Csiszár, A.; Hersch, N.; Fischer, L. S.; Brühmann, S.; Körber, S.; Litschko, C.; Mijanovic, L. et al.; Kaufmann, T.; Lange, F.; Springer, R.; Pich, A.; Jakobs, S.; Peckham, M.; Tarantola, M.; Grashoff, C.; Merkel, R.; Faix, J.: Decisive role of mDia-family formins in cell cortex function of highly adherent cells. Science Advances 10 (44), eadp5929 (2024)

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Sahl, S. J.; Matthias, J.; Inamdar, K.; Weber, M.; Khan, T. A.; Brüser, C.; Jakobs, S.; Becker, S.; Griesinger, C.; Broichhagen, J. et al.; Hell, S. W.: Direct optical measurement of intramolecular distances with angstrom precision. Science 386 (6718), pp. 180 - 187 (2024)

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Reshetniak, S.; Bogaciu, C. A.; Bonn, S.; Brose, N.; Cooper, B. H.; D'Este, E.; Fauth, M.; Fernández‐Busnadiego, R.; Fiosins, M.; Fischer, A. et al.; Georgiev, S. V.; Jakobs, S.; Klumpp, S.; Köster, S.; Lange, F.; Lipstein, N.; Macarrón‐Palacios, V.; Milovanovic, D.; Moser, T.; Müller, M.; Opazo, F.; Outeiro, T. F.; Pape, C.; Priesemann, V.; Rehling, P.; Salditt, T.; Schlüter, O.; Simeth, N.; Steinem, C.; Tchumatchenko, T.; Tetzlaff, C.; Tirard, M.; Urlaub, H.; Wichmann, C.; Wolf, F.; Rizzoli, S. O.: The synaptic vesicle cluster as a controller of pre‐ and postsynaptic structure and function. The Journal of Physiology (2024)

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Van den Eynde, R.; Hertel, F.; Abakumov, S.; Krajnik, B.; Hugelier, S.; Auer, A.; Hellmeier, J.; Schlichthaerle, T.; Grattan, R. M.; Lidke, D. S. et al.; Jungmann, R.; Leutenegger, M.; Vandenberg, W.; Dedecker, P.: Simultaneous multicolor fluorescence imaging using PSF splitting. Nature Methods 21, pp. 1801 - 1805 (2024)

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Remmel, M.; Matthias, J.; Lincoln, R.; Keller‐Findeisen, J.; Butkevich, A. N.; Bossi, M. L.; Hell, S. W.: Photoactivatable Xanthone (PaX) Dyes Enable Quantitative, Dual Color, and Live-Cell MINFLUX Nanoscopy. Small Methods 8 (9), 2301497 (2024)

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Schleske, J. M.; Hubrich, J.; Wirth, J. O.; D’Este, E.; Engelhardt, J.; Hell, S. W.: MINFLUX reveals dynein stepping in live neurons. Proceedings of the National Academy of Sciences of the United States of America 121 (38), e2412241121 (2024)

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Naas, J.; Nies, G.; Li, H.; Stoldt, S.; Schmitzer, B.; Jakobs, S.; Munk, A.: MultiMatch: geometry-informed colocalization in multi-color super-resolution microscopy. Communications Biology 7, 1139 (2024)

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Stephan, T.; Ilgen, P.; Jakobs, S.: Visualizing mitochondrial dynamics at the nanoscale. Light: Science & Applications 13, 244 (2024)

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Kim, D.; Bossi, M. L.; Belov, V. N.; Hell, S. W.: Supramolecular Complex of Cucurbit[7]uril with Diketopyrrolopyrole Dye: Fluorescence Boost, Biolabeling and Optical Microscopy. Angewandte Chemie International Edition 63 (36), e202410217 (2024)

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Bredfeldt, J.-E.; Oracz, J.; Kiszka, K. A.; Moosmayer, T.; Weber, M.; Sahl, S. J.; Hell, S. W.: Bleaching protection and axial sectioning in fluorescence nanoscopy through two-photon activation at 515 nm. Nature Communications 15, 7472 (2024)

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Aich, A.; Boshnakovska, A.; Witte, S.; Gall, T.; Unthan-Fechner, K.; Yousefi, R.; Chowdhury, A.; Dahal, D.; Methi, A.; Kaufmann, S. et al.; Silbern, I.; Prochazka, J.; Nichtova, Z.; Palkova, M.; Raishbrook, M.; Koubkova, G.; Sedlacek, R.; Tröder, S.E.; Zevnik, B.; Riedel, D.; Michanski, S.; Möbius, W.; Ströbel, P.; Lüchtenborg, C.; Giavalisco, P.; Urlaub, H.; Fischer, A.; Brügger, B.; Jakobs, S.; Rehling, P.: Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver. Nature Communications 15, 6914 (2024)

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Lukinavičius, G.; Alvelid, J.; Gerasimaitė, R.; Rodilla-Ramirez, C.; Nguyễn, V. T.; Vicidomini, G.; Bottanelli, F.; Han, K. Y.; Testa, I.: Stimulated emission depletion microscopy. Nature Reviews Methods primers 4 (1), 56 (2024)

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DʼEste, E.; Lukinavičius, G.; Lincoln, R.; Opazo, F.; Fornasiero, E.F.: Advancing cell biology with nanoscale fluorescence imaging: essential practical considerations. Trends in Cell Biology 34 (8), pp. 671 - 684 (2024)

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Khan, T. A.; Stoldt, S.; Bossi, M. L.; Belov, V. N.; Hell, S. W.: β-Galactosidase- and Photo-Activatable Fluorescent Probes for Protein Labeling and Super-Resolution STED Microscopy in Living Cells. Molecules 29, 3596 (2024)

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Proksch, K.; Werner, F.; Keller-Findeisen, J.; Ta, H.; Munk, A.: Toward quantitative super-resolution microscopy: molecular maps with statistical guarantees. Microscopy 73 (3), pp. 287 - 300 (2024)

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Wirth, J. O.; Schentarra, E.-M.; Scheiderer, L.; Macarrón-Palacios, V.; Tarnawski, M.; Hell, S. W.: Uncovering kinesin dynamics in neurites with MINFLUX. Communications Biology 7, 661 (2024)

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Chen, J.; Stephan, T.; Gaedke, F.; Liu, T.; Li, Y.; Schauss, A.; Chen, P.; Wulff, V.; Jakobs, S.; Jüngst, C. et al.; Chen, Z.: An aldehyde-crosslinking mitochondrial probe for STED imaging in fixed cells. PNAS 121 (19), e2317703121 (2024)

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Palikyras, S.; Sofiadis, K.; Stavropoulou, A.; Danieli-Mackay, A.; Varamogianni-Mamatsi, V.; Hörl, D.; Nasiscionyte, S.; Zhu, Y.; Papadionysiou, I.; Papadakis, A. et al.; Josipovic, N.; Zirkel, A.; O'Connell, A.; Loughran, G.; Keane, J.; Michel, A.; Wagner, W.; Beyer, A.; Harz, H.; Leonhardt, H.; Lukinavičius, G.; Nikolaou, C.; Papantonis, A.: Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor. Aging Cell 23 (4), e14083 (2024)

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Scheiderer, L.; von der Emde, H.; Hesselink, M.; Weber, M.; Hell, S. W.: MINSTED tracking of single biomolecules. Nature Methods 21, pp. 569 - 573 (2024)

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Schweighofer, S. V.; Jans, D. C.; Keller-Findeisen, J.; Folmeg, A.; Ilgen, P.; Bates, M.; Jakobs, S.: Endogenous BAX and BAK form mosaic rings of variable size and composition on apoptotic mitochondria. Cell Death & Differentiation 31, pp. 469 - 478 (2024)

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Rickert, J. D.; Held, M. O.; Engelhardt, J.; Hell, S. W.: 4Pi MINFLUX arrangement maximizes spatio-temporal localization precision of fluorescence emitter. PNAS 121 (11), e2318870121 (2024)

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Ebert, K.E.; Belov, V. N.; John, M.; Weiss, T.; Brüning, T.; Hayen, H.; Koch, H.M.; Bury, D.: Identification, Organic Synthesis, and Sensitive Analysis of a cis-Homosalate-Specific Exposure Biomarker. Chemical Research in Toxicology 37 (2), pp. 285 - 291 (2024)

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Kolarski, D.; Steinbach, P.; Bannwarth, C.; Klaue, K.; Hecht, S.: Diaryltriazolium Photoswitch: Reaching a Millisecond Cycloreversion with High Stability and NIR Absorption. Angewandte Chemie International Edition 63 (8), e202318015 (2024)

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Schettgen, T.; Belov, V. N.; Kraus, T.; Ziegler, P.: A novel method for the accurate quantification of two isomeric mercapturic acids of 1,3-dichlorobenzene in human urine using isotope dilution online-SPE-LC-MS/MS. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 1234, 124034 (2024)

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Knorr, G.; Bossi, M.L.; Butkevich, A.N.; Hell, S. W.: Synthesis of Thioxanthone 10,10-Dioxides and Sulfone-Fluoresceins via Pd-Catalyzed Sulfonylative Homocoupling. Organic Letters 26 (4), pp. 945 - 949 (2024)

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Wegener, J. W.; Mitronova, G.; Elshareif, L.; Quentin, C.; Belov, V. N.; Pochechueva, T.; Hasenfuss, G.; Ackermann, L.; Lehnart, S. E.: A dual-targeted drug inhibits cardiac ryanodine receptor Ca²⁺ leak but activates SERCA2a Ca²⁺ uptake. Life science alliance 7 (2), e202302278 (2024)

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Hintze, A.; Lange, F.; Steyer, A. M.; Anstatt, J.; Möbius, W.; Jakobs, S.; Wichmann, C.: Developmental changes of the mitochondria in the murine anteroventral cochlear nucleus. iScience 27 (1), 108700 (2024)

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Breindl, M.; Spitzer, D.; Gerasimaitė, R.; Kairys, V.; Schubert, T.; Henfling, R.; Schwartz, U.; Lukinavičius, G.; Manelytė, L.: Biochemical and cellular insights into the Baz2B protein, a non-catalytic subunit of the chromatin remodeling complex. Nucleic Acids Research 52 (1), pp. 337 - 354 (2024)

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Stephan, T.; Stoldt, S.; Barbot, M.; Carney, T. D.; Lange, F.; Bates, M.; Bou Dib, P.; Inamdar, K.; Shcherbata, H. R.; Meinecke, M. et al.; Riedel, D.; Dennerlein, S.; Rehling, P.; Jakobs, S.: Drosophila MIC10b can polymerize into cristae-shaping filaments. Life science alliance 7 (4), e202302177 (2024)

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Mitronova, G.; Quentin, C.; Belov, V. N.; Wegener, J.W.; Kiszka, K. A.; Lehnart, S.E.: 1,4-Benzothiazepines with Cyclopropanol Groups and Their Structural Analogues Exhibit Both RyR2-Stabilizing and SERCA2a-Stimulating Activities. Journal of Medicinal Chemistry 66 (23), pp. 15761 - 15775 (2023)

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Aktalay, A.; Khan, T. A.; Bossi, M. L.; Belov, V. N.; Hell, S. W.: Photoactivatable carbo- and silicon-rhodamines and their application in MINFLUX nanoscopy. Angewandte Chemie 135 (41), e202302781 (2023)

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Orange kedem, R.; Opatovski, N.; Xiao, D.; Ferdman, B.; Alalouf, O.; Pal, S. K.; Wang, Z.; von der Emde, H.; Weber, M.; Sahl, S. J. et al.; Ponjavic, A.; Arie, A.; Hell, S. W.; Shechtman, Y.: Near index matching enables solid diffractive optical element fabrication via additive manufacturing. Light: Science & Applications 12, 222 (2023)

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Kim, D.; Stoldt, S.; Weber, M.; Jakobs, S.; Belov, V. N.; Hell, S. W.: A Bright Surprise: Live-Cell Labeling with Negatively Charged Fluorescent Probes based on Disulfonated Rhodamines and HaloTag. Chemistry Methods 3 (9), e202200076 (2023)

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Aktalay, A.; Lincoln, R.; Heynck, L.; Lima, M. A. d. R. B. F.; Butkevich, A. N.; Bossi, M. L.; Hell, S. W.: Bioorthogonal Caging-Group-Free Photoactivatable Probes for Minimal-Linkage-Error Nanoscopy. ACS Central Science 9 (8), pp. 1581 - 1590 (2023)

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Zelená, A.; Blumberg, J.; Probst, D.; Gerasimaitė, R.; Lukinavičius, G.; Schwarz, U. S.; Köster, S.: Force generation in human blood platelets by filamentous actomyosin structures. Biophysical Journal 122 (16), pp. 3340 - 3353 (2023)

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Michanski, S.; Henneck, T.; Mukhopadhyay, M.; Steyer, A. M.; Gonzalez, P.A.; Grewe, K.; Ilgen, P.; Gültas, M.; Fornasiero, E.F.; Jakobs, S. et al.; Möbius, W.; Vogl, C.; Pangršič, T.; Rizzoli, S.O.; Wichmann, C.: Age-dependent structural reorganization of utricular ribbon synapses. Frontiers in Cell and Developmental Biology 11, 1178992 (2023)

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Ebrahimi, V.; Stephan, T.; Kim, J.; Carravilla, P.; Eggeling, C.; Jakobs, S.; Han, K. Y.: Deep learning enables fast, gentle STED microscopy. Communications Biology 6 (1), 674 (2023)

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Pradhan, S.; Apaydin, S.; Bucevičius, J.; Gerasimaitė, R.; Kostiuk, G.; Lukinavičius, G.: Sequence-specific DNA labelling for fluorescence microscopy. Biosensors and Bioelectronics 230, 115256 (2023)

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Wrobel, S. A.; Koslitz, S.; Belov, V. N.; Bury, D.; Hayen, H.; Brüning, T.; Koch, H. M.; Käfferlein, H. U.: Quantitation of 6-chloronicotinic acid and 2-chloro-1,3-thiazole-5-carboxylic acid and their glycine conjugates in human urine to assess neonicotinoid exposure. Environmental Research 226, 115609 (2023)

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Weber, M.; von der Emde, H.; Leutenegger, M.; Gunkel, P.; Sambandan, S.; Khan, T. A.; Keller-Findeisen, J.; Cordes, V. C.; Hell, S. W.: MINSTED nanoscopy enters the Ångström localization range. Nature Biotechnology 41, pp. 569 - 576 (2023)

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Remmel, M.; Scheiderer, L.; Butkevich, A.; Bossi, M. L.; Hell, S. W.: Accelerated MINFLUX Nanoscopy, through Spontaneously Fast-Blinking Fluorophores. Small 19 (12), 2206026 (2023)

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Publications

Journal Article (620)