Publications of Dmitry E. Agafonov
All genres
Journal Article (19)
Journal Article
9 (9), eadf178 (2023)
Regulation of 3′ splice site selection after step 1 of splicing by spliceosomal C* proteins. Science Advances
Journal Article
371 (6526), pp. 305 - 309 (2021)
Structure of a transcribing RNA polymerase II–U1 snRNP complex. Science
Journal Article
370 (6523), eabc3753 (2020)
Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science
Journal Article
80 (1), pp. 127 - 139.e6 (2020)
Structural insights into the roles of metazoan-specific splicing factors in the human step 1 spliceosome. Molecular Cell
Journal Article
583 (7815), pp. 310 - 313 (2020)
Molecular architecture of the human 17S U2 snRNP. Nature
Journal Article
172 (3), pp. 454 - 464, e1-e5 (2018)
Structure and conformational dynamics of the human spliceosomal Bact complex. Cell
Journal Article
170 (4), pp. 701 - 713, e1 - e4 (2017)
Cryo-EM structure of a pre-catalytic human spliceosome primed for activation. Cell
Journal Article
6, e23533 (2017)
Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation. eLife
Journal Article
542 (7641), pp. 318 - 323 (2017)
Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature
Journal Article
22 (9), pp. 1329 - 1337 (2016)
ATPγS stalls splicing after B complex formation but prior to spliceosome activation. RNA
Journal Article
7, 11997 (2016)
A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity. Nature Communications
Journal Article
5, e15564 (2016)
The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction. eLife
Journal Article
351 (6280), pp. 1416 - 1420 (2016)
Molecular architecture of the human U4/U6.U5 tri-snRNP. Science
Journal Article
11 (9), e1005539 (2015)
Dynamic contacts of U2, RES, Cwc25, Prp8 and Prp45 proteins with the Pre-mRNA branch-site and 3' splice site during catalytic activation and step 1 catalysis in yeast spliceosomes. PLoS Genetics
Journal Article
21 (11), pp. 1993 - 2005 (2015)
Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5‘ splice site. RNA
Journal Article
111 (44), pp. 15622 - 15629 (2014)
Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells. Proceedings of the National Academy of Sciences of the United States of America
Journal Article
31 (13), pp. 2667 - 2682 (2011)
Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method. Molecular and Cellular Biology
Journal Article
30 (9), pp. 2105 - 2119 (2010)
Molecular architecture of the human Prp19/CDC5L complex. Molecular and Cellular Biology
Journal Article
29 (13), pp. 3700 - 3709 (2009)
HIS-24 linker histone and SIR-2.1 deacetylase induce H3K27me3 in Caenorhabditis elegans germ line. Molecular and Cellular Biology