Publications of R. Lührmann

Lührmann, R.; Stark, H.: Structural mapping of spliceosomes by electron microscopy. Current Opinion in Structural Biology 19, pp. 96 - 102 (2009)

Pena, V.; Jovin, S. M.; Fabrizio, P.; Orlowski, J.; Bujnicki, J. M.; Lührmann, R.; Wahl, M. C.: Common design principles in the spliceosomal RNA helicase Brr2 and in the Hel308 DNA helicase. Molecular Cell 35 (4), pp. 454 - 466 (2009)

Yu, Y.; Maroney, P. A.; Denker, J. A.; Zhang, X. H. F.; Dybkov, O.; Luehrmann, R.; Jankowsky, E.; Chasin, L. A.; Nilsen, T. W.: Dynamic regulation of alternative splicing by silencers that modulate 5´ splice site competition. Cell 135 (7), pp. 1224 - 1236 (2008)

Trowitzsch, S.; Weber, G.; Luehrmann, R.; Wahl, M. C.: An unusual RNA recognition motif acts as a scaffold for multiple proteins in the pre-mRNA retention and splicing complex. The Journal of Biological Chemistry 283 (47), pp. 32317 - 32327 (2008)

Haecker, I.; Sander, B.; Golas, M. M.; Wolf, E.; Karagoez, E.; Kastner, B.; Stark, H.; Fabrizio, P.; Luehrmann, R.: Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy. Nature Structural and Molecular Biology 15 (11), pp. 1206 - 1212 (2008)

Pena, V.; Rozov, A.; Fabrizio, P.; Luehrmann, R.; Wahl, M. C.: Structure and function of an RNase H domain at the heart of the spliceosome. The EMBO Journal 27 (21), pp. 2929 - 2940 (2008)

Licht, K.; Medenbach, J.; Luehrmann, R.; Kambach, C.; Bindereif, A.: 3'-cyclic phosphorylation of U6 snRNA leads to recruitment of recycling factor p110 through LSm proteins. RNA 14 (8), pp. 1532 - 1538 (2008)

Pessa, H. K.; Will, C. L.; Meng, X.; Schneider, C.; Watkins, N. J.; Peraelae, N.; Nymark, M.; Turunen, J. J.; Luehrmann, R.; Frilander, M. J.: Minor spliceosome components are predominantly localized in the nucleus. Proceedings of the National Academy of Sciences of the United States of America 105, pp. 8655 - 8660 (2008)

Mathew, R.; Hartmuth, K.; Moehlmann, S.; Urlaub, H.; Ficner, R.; Luehrmann, R.: Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome. Nature Structural & Molecular Biology 15 (5), pp. 435 - 443 (2008)

Turunen, J. J.; Will, C. L.; Grote, M.; Luehrmann, R.; Frilander, M. J.: The U11-48K protein contacts the 5' splice site of U12-Type introns and the U11-59K protein. Molecular and Cellular Biology 28 (10), pp. 3548 - 3560 (2008)

Bessonov, S.; Anokhina, M.; Will, C. L.; Urlaub, H.; Luehrmann, R.: Isolation of an active step I spliceosome and composition of its RNP core. Nature 452 (7189), pp. 846 - 850 (2008)

Rino, J.; Carvalho, T.; Braga, J.; Desterro, J. M.; Luehrmann, R.; Carmo-Fonseca, M.: A stochastic view of spliceosome assembly and recycling in the nucleus. PLoS Computational Biology 3 (10), e201, pp. 2019 - 2031 (2007)

Watkins, N. J.; Lemm, I.; Luehrmann, R.: Involvement of nuclear import and export factors in U8 box C/D snoRNP biogenesis. Molecular and Cellular Biology 27 (20), pp. 7018 - 7027 (2007)

Kuehn-Hoelsken, E.; Dybkov, O.; Sander, B.; Luehrmann, R.; Urlaub, H.: Improved identification of enriched peptide–RNA cross-links from ribonucleoprotein particles (RNPs) by mass spectrometry. Nucleic Acids Research 35 (15), e95 (2007)

Nielsen, T. K.; Liu, S.; Luehrmann, R.; Ficner, R.: Structural basis for the bifunctionality of the U5 snRNP 52K protein (CD2BP2). Journal of Molecular Biology 369 (4), pp. 902 - 908 (2007)

Behzadnia, N.; Golas, M. M.; Hartmuth, K.; Sander, B.; Kastner, B.; Deckert, J.; Dube, P.; Will, C. L.; Urlaub, H.; Stark, H. et al.; Luehrmann, R.: Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. The EMBO Journal 26 (6), pp. 1737 - 1748 (2007)

Pena, V.; Liu, S.; Bujnicki, J. M.; Luehrmann, R.; Wahl, M. C.: Structure of a multipartite protein-protein interaction domain in splicing factor Prp8 and its link to retinitis pigmentosa. Molecular Cell 25 (4), pp. 615 - 624 (2007)

Merz, C.; Urlaub, H.; Will, C. L.; Luehrmann, R.: Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment. RNA 13, pp. 116 - 128 (2007)

Sander, B.; Golas, M. M.; Makarov, E. M.; Brahms, H.; Kastner, B.; Luehrmann, R.; Stark, H.: Organization of Core Spliceosomal Components U5 snRNA Loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as Revealed by Electron Cryomicroscopy. Molecular Cell 24 (2), pp. 267 - 278 (2006)

Schultz, A.; Nottrott, S.; Hartmuth, K.; Luehrmann, R.: RNA structural requirements for the association of the spliceosomal hPrp31 protein with the U4 and U4atac small nuclear ribonucleoprotein. Journal of Biological Chemistry 281 (38), pp. 28278 - 28286 (2006)