Publications of Robert Fledrich

Gargareta, V.-I.; Berghoff, S. A.; Krauter, D.; Hümmert, S.; Marshall‐Phelps, K. L. H.; Möbius, W.; Nave, K.-A.; Fledrich, R.; Werner, H. B.; Eichel-Vogel, M. A.: Myelinated peripheral axons are more vulnerable to mechanical trauma in a model of enlarged axonal diameters. Glia 72 (9), pp. 1572 - 1589 (2024)

Schäffner, E.; Bosch-Queralt, M.; Edgar, J. M.; Lehning, M.; Strauß, J.; Fleischer, N.; Kungl, T.; Wieghofer, P.; Berghoff, S. A.; Reinert, T. et al.; Krueger, M.; Morawski, M.; Möbius, W.; Barrantes-Freer, A.; Stieler, J.; Sun, T.; Saher, G.; Schwab, M. H.; Wrede, C.; Frosch, M.; Prinz, M.; Reich, D. S.; Flügel, A.; Stadelmann, C.; Fledrich, R.; Nave, K.-A.; Stassart, R. M.: Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease. Nature Neuroscience 26, pp. 1218 - 1228 (2023)

Martens, A.-K.; Erwig, M. S.; Patzig, J.; Fledrich, R.; Füchtbauer, E.; Werner, H. B.: Targeted inactivation of the Septin2 and Septin9 genes in myelinating Schwann cells of mice. Cytoskeleton 80 (7-8), pp. 290 - 302 (2023)

Eichel, M. A.; Gargareta, V.-I.; D’Este, E.; Fledrich, R.; Kungl, T.; Buscham, T. J.; Lüders, K. A.; Miracle, C.; Jung, R. B.; Distler, U. et al.; Kusch, K.; Möbius, W.; Hülsmann, S.; Tenzer, S.; Nave, K.-A.; Werner, H. B.: CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves. Nature Communications 11 (1), 4514 (2020)

Siems, S. B.; Jahn, O.; Eichel, M. A.; Kannaiyan, N.; Wu, L. M. N.; Sherman, D. L.; Kusch, K.; Hesse, D.; Jung, R. B.; Fledrich, R. et al.; Sereda, M. W.; Rossner, M. J.; Brophy, P. J.; Werner, H. B.: Proteome profile of peripheral myelin in healthy mice and in a neuropathy model. eLife 9, e51406 (2020)

Fledrich, R.; Kungl, T.; Nave, K.-A.; Stassart, R. M.: Axo-glial interdependence in peripheral nerve development. Development 146 (21), dev151704 (2019)

Fledrich, R.; Akkermann, D.; Schütza, V.; Abdelaal, T. A. M.; Hermes, D.; Schäffner, E.; Soto Bernardini, M. C.; Götze, T.; Klink, A.; Kusch, K. et al.; Krueger, M.; Kungl, T.; Frydrychowicz, C.; Möbius, W.; Brück, W.; Mueller, W. C.; Bechmann, I.; Sereda, M. W.; Schwab, M. H.; Nave, K.-A.; Stassart, R. M.: NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies. Nature Communications 10, 1467 (2019)

Fledrich, R.; Abdelaal, T. A. M.; Rasch, L.; Bansal, V.; Schütza, V.; Brügger, B.; Lüchtenborg, C.; Prukop, T.; Stenzel, J.; Rahman, R.U. et al.; Hermes, D.; Ewers, D.; Möbius, W.; Ruhwedel, T.; Katona, I.; Weis, J.; Klein, D.; Martini, R.; Brück, W.; Müller, W.C.; Bonn, S.; Bechmann, I.; Nave, K.-A.; Stassart, R. M.; Sereda, M. W.: Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy. Nature Communications 9, 3025 (2018)

Fledrich, R.; Mannil, M.; Leha, A.; Ehbrecht, C.; Solari, A.; Pelayo-Negro, A. L.; Berciano, J.; Schlotter-Weigel, B.; Schnizer, T. J.; Prukop, T. et al.; Garcia-Angarita, N.; Czesnik, D.; Haberlová, J.; Mazanec, R.; Paulus, W.; Beissbarth, T.; Walter, M. C.; CMT-TRIAAL; Hogrel, J.-Y.; Dubourg, O.; Schenone, A.; Baets, J.; De Jonghe, P.; Shy, M. E.; Horvath, R.; Pareyson, D.; Seeman, P.; Young, P.; Sereda, M. W.: Biomarkers predict outcome in Charcot-Marie-Tooth disease 1A. Journal of Neurology, Neurosurgery & Psychiatry 88 (11), pp. 941 - 952 (2017)

Patzig, J.; Kusch, K.; Fledrich, R.; Eichel, M. A.; Lüders, K. A.; Möbius, W.; Sereda, M. W.; Nave, K.-A.; Martini, R.; Werner, H. B.: Proteolipid protein modulates preservation of peripheral axons and premature death when myelin protein zero is lacking. Glia 64 (1), pp. 155 - 174 (2016)

Fledrich, R.; Stassart, R. M.; Klink, A.; Rasch, L. M.; Prukop, T.; Haag, L.; Czesnik, D.; Kungl, T.; Abdelaal, T. A. M.; Keric, N. et al.; Stadelmann, C.; Brück, W.; Nave, K.-A.; Sereda, M. W.: Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A. Nature Medicine 20 (9), pp. 1055 - 1061 (2014)

Prukop, T.; Epplen, D. B.; Nientiedt, T.; Wichert, S. P.; Fledrich, R.; Stassart, R. M.; Rossner, M. J.; Edgar, J. M.; Werner, H. B.; Nave, K.-A. et al.; Sereda, M. W.: Progesterone antagonist therapy in a Pelizaeus-Merzbacher mouse model. The American Journal of Human Genetics 94 (4), pp. 533 - 546 (2014)

Stassart, R. M.; Fledrich, R.; Velanac, V.; Brinkmann, B. G.; Schwab, M. H.; Meijer, D.; Sereda, M. W.; Nave, K.-A.: A role for Schwann cell-derived neuregulin-1 in remyelination. Nature Neuroscience 16 (1), pp. 48 - 54 (2013)

Fledrich, R.; Stassart, R. M.; Sereda, M. W.: Murine therapeutic models for Charcot-Marie-Tooth (CMT) disease. British Medical Bulletin 102 (1), pp. 89 - 113 (2012)

Makoukji, J.; Belle, M.; Meffre, D.; Stassart, R.; Grenier, J.; Shackleford, G. G.; Fledrich, R.; Fonte, C.; Branchu, J.; Goulard, M. et al.; de Waele, C.; Charbonnier, F.; Sereda, M. W.; Baulieu, E.-E.; Schumacher, M.; Bernard, S.; Massaad, C.: Lithium enhances remyelination of peripheral nerves. Proceedings of the National Academy of Sciences of the United States of America 109 (10), pp. 3973 - 3978 (2012)

Fledrich, R.; Schlotter-Weigel, B.; Schnizer, T. J.; Wichert, S. P.; Stassart, R. M.; Meyer zu Hörste, G.; Klink, A.; Weiss, B. G.; Haag, U.; Walter, M. C. et al.; Rautenstrauss, B.; Paulus, W.; Rossner, M. J.; Sereda, M. W.: A rat model of Charcot-Marie-Tooth disease 1A recapitulates disease variability and supplies biomarkers of axonal loss in patients. Brain 135 (1), pp. 72 - 87 (2012)

Gess, B.; Röhr, D.; Fledrich, R.; Sereda, M. W.; Kleffner, I.; Humberg, A.; Nowitzki, J.; Strecker, J.-K.; Halfter, H.; Young, P.: Sodium-dependent vitamin C transporter 2 deficiency causes hypomyelination and extracellular matrix defects in the peripheral nervous system. The Journal of Neuroscience 31 (47), pp. 17180 - 17192 (2011)

Meyer zu Hoerste, G.; Miesbach, T. A.; Müller, J. I.; Fledrich, R.; Stassart, R. M.; Kieseier, B. C.; Coleman, M. P.; Sereda, M. W.: The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration. Neurobiology of Disease 42 (1), pp. 1 - 8 (2011)

Fledrich, R.; Kungl, T.; Nave, K.-A.; Stassart, R. M.: Axo-glial interdependance in peripheral nerve development. Development 146 (21), dev151704 (2019)

Schäffner, E.; Edgar, J. M.; Lehning, M.; Strauß, J.; Bosch-Queralt, M.; Wieghofer, P.; Berghoff, S. A.; Krueger, M.; Morawski, M.; Reinert, T. et al.; Möbius, W.; Barrantes-Freer, A.; Prinz, M.; Reich, D.S.; Flügel, A.; Stadelmann, C.; Fledrich, R.; Stassart, R. M.; Nave, K.-A.: Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease. bioRxiv (2021)