Publications of Dirk Görlich

Loreau, V.; Koolhaas, W. H.; Chan, E. H.; De Boissier, P.; Brouilly, N.; Avosani, S.; Sane, A.; Pitaval, C.; Reiter, S.; Luis, N. M. et al.; Mangeol, P.; von Philipsborn, A. C.; Rupprecht, J.-F.; Görlich, D.; Habermann, B. H.; Schnorrer, F.: Titin-dependent biomechanical feedback tailors sarcomeres to specialized muscle functions in insects. Science Advances 11 (19), eads8716 (2025)

Solà Colom, M.; Fu, Z.; Gunkel, P.; Güttler, T.; Trakhanov, S.; Srinivasan, V.; Gregor, K.; Pleiner, T.; Görlich, D.: A checkpoint function for Nup98 in nuclear pore formation suggested by novel inhibitory nanobodies. The EMBO Journal 43 (11), pp. 2198 - 2232 (2024)

Fu, L.; Weiskopf, E.N.; Akkermans, O.; Swanson, N.A.; Cheng, S.; Schwartz, T.U.; Görlich, D.: HIV-1 capsids enter the FG phase of nuclear pores like a transport receptor. Nature 626, pp. 843 - 851 (2024)

Aksu, M.; Kumar, P.; Güttler, T.; Taxer, W.; Gregor, K.; Mußil, B.; Rymarenko, O.; Stegmann, K.M.; Dickmanns, A.; Gerber, S. et al.; Reineking, W.; Schulz, C.; Henneck, T.; Mohamed, A.; Pohlmann, G.; Ramazanoglu, M.; Mese, K.; Groß, U.; Ben-Yedidia, T.; Ovadia, O.; Fischer, D.W.; Kamensky, M.; Reichman, A.; Baumgärtner, W.; von Köckritz-Blickwede, M.; Dobbelstein, M.; Görlich, D.: Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters. Antiviral Research 221, 105778 (2024)

Zibat, A.; Zhang, X.; Dickmanns, A.; Stegmann, K.M.; Dobbelstein, A.W.; Alachram, H.; Soliwoda, R.; Salinas, G.; Groß, U.; Görlich, D. et al.; Kschischo, M.; Wollnik, B.; Dobbelstein, M.: N4-hydroxycytidine, the active compound of Molnupiravir, promotes SARS-CoV-2 mutagenesis and escape from a neutralizing nanobody. iScience 26 (10), 107786 (2023)

Ng, S. C.; Biswas, A.; Huyton, T.; Schünemann, J.; Reber, S.; Görlich, D.: Barrier-properties of Nup98 FG phases ruled by FG motif identity and inter-FG spacer length. Nature Communications 14, 747 (2023)

Loreau, V.; Rees, R.; Chan, E. H.; Taxer, W.; Gregor, K.; Mußil, B.; Pitaval, C.; Luis, N. M.; Mangeol, P.; Schnorrer, F. et al.; Görlich, D.: A nanobody toolbox to investigate localisation and dynamics of Drosophila titins and other key sarcomeric proteins. eLife 12, e79343 (2023)

Schueder, F.; Mangeol, P.; Chan, E. H.; Rees, R.; Schünemann, J.; Jungmann, R.; Görlich, D.; Schnorrer, F.: Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nanoarchitecture in flight muscles. eLife 12, e79344 (2023)

Ng, S. C.; Görlich, D.: A simple thermodynamic description of phase separation of Nup98 FG domains. Nature Communications 13, 6172 (2022)

Huyton, T.; Jaiswal, M.; Taxer, W.; Fischer, M.; Görlich, D.: Crystal structures of FNIP/FGxxFN motif-containing leucine-rich repeat proteins. Scientific Reports 12, 16430 (2022)

Modepalli, S.; Martinez-Morilla, S.; Venkatesan , S.; Fasano, J.; Paulsen, K.; Görlich, D.; Hattangadi, S.; Kupfer, G. M.: An In Vivo Model for Elucidating the Role of an Erythroid-Specific Isoform of Nuclear Export Protein Exportin 7 (Xpo7) in Murine Erythropoiesis. Experimental Hematology 114, pp. 22 - 32 (2022)

Blaurock, C.; Breithaupt, A.; Weber, S.; Wylezich, C.; Keller, M.; Mohl, B.-P.; Görlich, D.; Groschup, M. H.; Sadeghi, B.; Höper, D. et al.; Mettenleiter, T. C.; Balkema-Buschmann, A.: Compellingly high SARS-CoV-2 susceptibility of Golden Syrian hamsters suggests multiple zoonotic infections of pet hamsters during the COVID-19 pandemic. Scientific Reports 12, 15069 (2022)

Stegmann, K. M.; Dickmanns, A.; Heinen, N.; Blaurock, C.; Karrasch, T.; Breithaupt, A.; Klopfleisch, R.; Uhlig, N.; Eberlein, V.; Issmail, L. et al.; Herrmann, S. T.; Schreieck, A.; Peelen, E.; Kohlhof, H.; Sadeghi, B.; Riek, A.; Speakman, J. R.; Groß, U.; Görlich, D.; Vitt, D.; Müller, T.; Grunwald, T.; Pfaender, S.; Balkema-Buschmann, A.; Dobbelstein, M.: Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication. iScience 25 (5), 104293 (2022)

Najbauer, E. E.; Ng, S. C.; Griesinger, C.; Görlich, D.; Andreas, L. B.: Atomic resolution dynamics of cohesive interactions in phase-separated Nup98 FG domains. Nature Communications 13, 1494 (2022)

García-García, M.; Sánchez-Perales, S.; Jarabo, P.; Calvo, E.; Huyton, T.; Fu, L.; Ng, S. C.; Sotodosos-Alonso, L.; Vázquez, J.; Casas-Tintó, S. et al.; Görlich, D.; Echarri, A.; Del Pozo, M. A.: Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP. Nature Communications 13, 1174 (2022)

Güttler, T.; Dobbelstein, M.; Görlich, D.: Therapeutische Nanobodies gegen SARS-CoV-2. Biospektrum 28, pp. 39 - 42 (2022)

Güttler, T.; Aksu, M.; Dickmanns, A.; Stegmann, K. M.; Gregor, K.; Rees, R.; Taxer, W.; Rymarenko, O.; Schünemann, J.; Dienemann, C. et al.; Gunkel, P.; Mussil, B.; Krull, J.; Teichmann, U.; Groß, U.; Cordes, V.; Dobbelstein, M.; Görlich, D.: Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies. EMBO Journal 40 (19), e107985 (2021)

Stegmann, K. M.; Dickmanns, A.; Gerber, S.; Nikolova, V.; Klemke, L.; Manzini, V.; Schlösser, D.; Bierwirth, C.; Freund, J.; Sitte, M. et al.; Lugert, R.; Salinas, G.; Meister, T. L.; Pfaender, S.; Görlich, D.; Wollnik, B.; Groß, U.; Dobbelstein, M.: The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models. Virus Research 302, 198469 (2021)

Ng, S. C.; Güttler, T.; Görlich, D.: Recapitulation of selective nuclear import and export with a perfectly repeated 12mer GLFG peptide. Nature Communications 12, 4047 (2021)

Frost, R.; Débarre, D.; Jana, S.; Bano, F.; Schünemann, J.; Görlich, D.; Richter, R. P.: A method to quantify molecular diffusion within thin solvated polymer films: A case study on films of natively unfolded nucleoporins. ACS Nano 14 (8), pp. 9938 - 9952 (2020)