Publications of Simone Eggert

Schilling, S.; August, A.; Meleux, M.; Conradt, C.; Tremmel, L. M.; Teigler, S.; Adam, V.; Müller, U. C.; Koo, E. H.; Kins, S. et al.; Eggert, S.: APP family member dimeric complexes are formed predominantly in synaptic compartments. Cell & Bioscience 13, 141 (2023)

Schilling, S.; Pradhan, A.; Heesch, A.; Helbig, A.; Blennow, K.; Koch, C.; Bertgen, L.; Koo, E. H.; Brinkmalm, G.; Zetterberg, H. et al.; Kins, S.; Eggert, S.: Differential effects of familial Alzheimer’s disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity. Acta Neuropathologica Communications 11, 87 (2023)

Busch, L.; Eggert, S.; Endres, K.; Bufe, B.: The Hidden Role of Non-Canonical Amyloid β Isoforms in Alzheimer’s Disease. Cells 11 (21), 3421 (2022)

Eggert, S.; Kins, S.; Endres, K.; Brigadski, T.: Brothers in arms: proBDNF/BDNF and sAPPα/Aβ-signaling and their common interplay with ADAM10, TrkB, p75NTR, sortilin, and sorLA in the progression of Alzheimer’s disease. Biological Chemistry 403 (1), pp. 43 - 71 (2022)

Nguyen, V. T. T.; König, S.; Eggert, S.; Endres, K.; Kins, S.: The role of mycotoxins in neurodegenerative diseases: current state of the art and future perspectives of research. Biological Chemistry 403 (1), pp. 3 - 26 (2022)

Witthohn, M.; Strieth, D.; Eggert, S.; Kins, S.; Ulber, R.; Muffler, K.: Heterologous production of a cyanobacterial bacteriocin with potent antibacterial activity. Current Research in Biotechnology 3, pp. 281 - 287 (2021)

Eggert, S.; Gruebl, T.; Rajender, R.; Rupp, C.; Sander, B.; Heesch, A.; Zimmermann, M.; Hoepfner, S.; Zentgraf, H.; Kins, S.: The Rab5 activator RME-6 is required for amyloid precursor protein endocytosis depending on the YTSI motif. Cellular and Molecular Life Sciences 77, pp. 5223 - 5242 (2020)

Endres, K.; Eggert, S.: Forschungskolleg “NeurodegX”. Neuroforum 26 (3), pp. 185 - 186 (2020)

August, A.; Schmidt, N.; Klingler, J.; Baumkötter, F.; Lechner, M.; Klement, J.; Eggert, S.; Vargas, C.; Wild, K.; Keller, S. et al.; Kins, S.: Copper and zinc ions govern the trans‐directed dimerization of APP family members in multiple ways. Journal of Neurochemistry 151 (5), pp. 626 - 641 (2019)

Eggert, S.; Thomas, C.; Kins, S.; Hermey, G.: Trafficking in Alzheimer’s Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin. Molecular Neurobiology 55, pp. 5809 - 5829 (2018)

Eggert, S.; Gonzalez, A. C.; Thomas, C.; Schilling, S.; Schwarz, S. M.; Tischer, C.; Adam, V.; Strecker, P.; Schmidt, V.; Willnow, T. E. et al.; Hermey, G.; Pietrzik, C. U.; Koo, E. H.; Kins, S.: Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA. Cellular and Molecular Life Sciences 75, pp. 301 - 322 (2018)

Schilling, S.; Mehr, A.; Ludewig, S.; Stephan, J.; Zimmermann, M.; August, A.; Strecker, P.; Korte, M.; Koo, E. H.; Müller, U. C. et al.; Kins, S.; Eggert, S.: APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission. The Journal of Neuroscience 37 (21), pp. 5345 - 5365 (2017)

Feilen, L. P.; Haubrich, K.; Strecker, P.; Probst, S.; Eggert, S.; Stier, G.; Sinning, I.; Konietzko, U.; Kins, S.; Simon, B. et al.; Wild, K.: Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction. Frontiers in Molecular Neuroscience 10, 140 (2017)

Herr, U.-M.; Strecker, P.; Storck, S. E.; Thomas, C.; Rabiej, V.; Junker, A.; Schilling, S.; Schmidt, N.; Dowds, C. M.; Eggert, S. et al.; Pietrzik, C. U.; Kins, S.: LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State. Frontiers in Molecular Neuroscience 10, 118 (2017)

Stahl, R.; Schilling, S.; Soba, P.; Rupp, C.; Hartmann, T.; Wagner, K.; Merdes, G.; Eggert, S.; Kins, S.: Shedding of APP limits its synaptogenic activity and cell adhesion properties. Frontiers in Cellular Neuroscience 8, 410 (2014)

Baumkotter, F.; Schmidt, N.; Vargas, C.; Schilling, S.; Weber, R.; Wagner, K.; Fiedler, S.; Klug, W.; Radzimanowski, J.; Nickolaus, S. et al.; Keller, S.; Eggert, S.; Wild, K.; Kins, S.: Amyloid Precursor Protein Dimerization and Synaptogenic Function Depend on Copper Binding to the Growth Factor-Like Domain. The Journal of Neuroscience 34 (33), pp. 11159 - 11172 (2014)

Jung, H.-J.; Kim, Y.-J.; Eggert, S.; Chung, K. C.; Choi, K. S.; Park, S. A.: Age-dependent increases in tau phosphorylation in the brains of type 2 diabetic rats correlate with a reduced expression of p62. Experimental Neurology 248, pp. 441 - 450 (2013)

Thyrock, A.; Ossendorf, E.; Stehling, M.; Kail, M.; Kurtz, T.; Pohlentz, G.; Waschbüsch, D.; Eggert, S.; Formstecher, E.; Müthing, J. et al.; Dreisewerd, K.; Kins, S.; Goud, B.; Barnekow, A.: A New Mint1 Isoform, but Not the Conventional Mint1, Interacts with the Small GTPase Rab6. PLoS One 8 (5), p. e64149 (2013)

Nagahara, A. H.; Mateling, M.; Kovacs, I.; Wang, L.; Eggert, S.; Rockenstein, E.; Koo, E. H.; Masliah, E.; Tuszynski, M. H.: Early BDNF Treatment Ameliorates Cell Loss in the Entorhinal Cortex of APP Transgenic Mice. The Journal of Neuroscience 33 (39), pp. 15596 - 15602 (2013)

Tyan, S.-H.; Shih, A. Y.-J.; Walsh, J. J.; Maruyama, H.; Sarsoza, F.; Ku, L.; Eggert, S.; Hof, P. R.; Koo, E. H.; Dickstein, D. L.: Amyloid precursor protein (APP) regulates synaptic structure and function. Molecular and Cellular Neuroscience 51 (1-2), pp. 43 - 52 (2012)