Publications of Torben Ruhwedel

Depp, C.; Sun, T.; Sasmita, A. O.; Spieth, L.; Berghoff, S. A.; Nazarenko, T.; Overhoff, K.; Steixner-Kumar, A. A.; Subramanian, S.; Arinrad, S. et al.; Ruhwedel, T.; Möbius, W.; Göbbels, S.; Saher, G.; Werner, H. B.; Damkou, A.; Zampar, S.; Wirths, O.; Thalmann, M.; Simons, M.; Saito, T.; Saido, T.; Krueger-Burg, D.; Kawaguchi, R.; Willem, M.; Haass, C.; Geschwind, D.; Ehrenreich, H.; Stassart, R. M.; Nave, K.-A.: Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease. Nature, in press (2023)

Djannatian, M.; Radha, S.; Weikert, U.; Safaiyan, S.; Wrede, C.; Deichsel, C.; Kislinger, G.; Rhomberg, A.; Ruhwedel, T.; Campbell, D. S. et al.; van Ham, T.; Schmid, B.; Hegermann, J.; Möbius, W.; Schifferer, M.; Simons, M.: Myelination generates aberrant ultrastructure that is resolved by microglia. Journal of Cell Biology 222 (3), e202204010 (2023)

Cheng, S.; Altmeppen, G.; So, C.; Welp, L.; Penir, S. M.; Ruhwedel, T.; Menelaou, K.; Harasimov, K.; Stützer, A.; Blayney, M. et al.; Elder, K.; Möbius, W.; Urlaub, H.; Schuh, M.: Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment. Science 378 (6617), eabq4835 (2022)

Düking, T.; Spieth, L.; Berghoff, S. A.; Piepkorn, L.; Schmidke, A. M.; Mitkovski, M.; Kannaiyan, N.; Hosang, L.; Scholz, P.; Shaib, A. H. et al.; Schneider, L. V.; Hesse, D.; Ruhwedel, T.; Sun, T.; Linhoff, L.; Trevisiol, A.; Köhler, S.; Pastor, A. M.; Misgeld, T.; Sereda, M.; Hassouna, I.; Rossner, M. J.; Odoardi, F.; Ischebeck, T.; de Hoz, L.; Hirrlinger, J.; Jahn, O.; Saher, G.: Ketogenic diet uncovers differential metabolic plasticity of brain cells. Science Advances 8 (37), eabo7639 (2022)

Buscham, T. J.; Eichel-Vogel, M. A.; Steyer, A. M.; Jahn, O.; Strenzke, N.; Dardawal, R.; Memhave, T. R.; Siems, S. B.; Müller, C.; Meschkat, M. et al.; Sun, T.; Ruhwedel, T.; Möbius, W.; Krämer-Albers, E.-M.; Boretius, S.; Nave, K.-A.; Werner, H. B.: Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5. eLife 11, e75523 (2022)

Hösli, L.; Binini, N.; Ferrari, K. D.; Thieren, L.; Looser, Z. J.; Zuend, M.; Zanker, H. S.; Berry, S.; Holub, M.; Möbius, W. et al.; Ruhwedel, T.; Nave, K.-A.; Giaume, C.; Weber, B.; Saab, A. S.: Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning. Cell Reports 38 (10), 110484 (2022)

Meschkat, M.; Steyer, A. M.; Weil, M.-T.; Kusch, K.; Jahn, O.; Piepkorn, L.; Agüi-Gonzalez, P.; Phan, N. T. N.; Ruhwedel, T.; Sadowski, B. et al.; Rizzoli, S. O.; Werner, H. B.; Ehrenreich, H.; Nave, K.-A.; Möbius, W.: White matter integrity in mice requires continuous myelin synthesis at the inner tongue. Nature Communications 13, 1163 (2022)

Spieth, L.; Berghoff, S. A.; Stumpf, S. K.; Winchenbach, J.; Michaelis, T.; Watanabe, T.; Gerndt, N.; Düking, T.; Hofer, S.; Ruhwedel, T. et al.; Shaib, A. H.; Willig, K. I.; Kronenberg, K.; Karst, U.; Frahm, J.; Rhee, J. S.; Minguet, S.; Möbius, W.; Kruse, N.; von der Brelie, C.; Michels, P.; Stadelmann, C.; Hülper, P.; Saher, G.: Anesthesia triggers drug delivery to experimental glioma in mice by hijacking caveolar transport. Neuro-Oncology Advances 3 (1), vdab140 (2021)

Berghoff, S. A.; Spieth, L.; Sun, T.; Hosang, L.; Schlaphoff, L.; Depp, C.; Düking, T.; Winchenbach, J.; Neuber, J.; Ewers, D. et al.; Scholz, P.; van der Meer, F.; Cantuti-Castelvetri, L.; Sasmita, A. O.; Meschkat, M.; Ruhwedel, T.; Möbius, W.; Sankowski, R.; Prinz, M.; Huitinga, I.; Sereda, M. W.; Odoardi, F.; Ischebeck, T.; Simons, M.; Stadelmann-Nessler, C.; Edgar, J. M.; Nave, K.-A.; Saher, G.: Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis. Nature Neuroscience 24, pp. 47 - 60 (2021)

Moore, S.; Meschkat, M.; Ruhwedel, T.; Trevisiol, A.; Tzvetanova, I.; Battefeld, A.; Kusch, K.; Kole, M. H. P.; Strenzke, N.; Möbius, W. et al.; de Hoz, L.; Nave, K.-A.: A role of oligodendrocytes in information processing. Nature Communications 11 (1), 5497 (2020)

Marshall-Phelps, K. L. H.; Kegel, L.; Baraban, M.; Ruhwedel, T.; Almeida, R. G.; Rubio-Brotons, M.; Klingseisen, A.; Benito-Kwiecinski, S. K.; Early, J. J.; Bin, J. M. et al.; Suminaite, D.; Livesey, M. R.; Möbius, W.; Poole, R. J.; Lyons, D. A.: Neuronal activity disrupts myelinated axon integrity in the absence of NKCC1b. Journal of Cell Biology 219 (7), e201909022 (2020)

Steyer, A. M.; Ruhwedel, T.; Nardis, C.; Werner, H. B.; Nave, K.-A.; Möbius, W.: Pathology of myelinated axons in the PLP-deficient mouse model of spastic paraplegia type 2 revealed by volume imaging using focused ion beam-scanning electron microscopy. Journal of Structural Biology 210 (2), 107492 (2020)

Stumpf, S. K.; Berghoff, S. A.; Trevisiol, A.; Spieth, L.; Düking, T.; Schneider, L. V.; Schlaphoff, L.; Dreha-Kulaczewski, S.; Bley, A.; Burfeind, D. et al.; Kusch, K.; Mitkovski, M.; Ruhwedel, T.; Guder, P.; Röhse, H.; Denecke, J.; Gärtner, J.; Möbius, W.; Nave, K.-A.; Saher, G.: Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus-Merzbacher disease. Acta Neuropathologica 138, pp. 147 - 161 (2019)

Steyer, A. M.; Ruhwedel, T.; Möbius, W.: Biological sample preparation by high-pressure freezing, microwave-assisted contrast enhancement, and minimal resin embedding for volume imaging. Journal of Visualized Experiments 145, e59156 (2019)

Fledrich, R.; Abdelaal, T. A. M.; Rasch, L.; Bansal, V.; Schütza, V.; Brügger, B.; Lüchtenborg, C.; Prukop, T.; Stenzel, J.; Rahman, R.U. et al.; Hermes, D.; Ewers, D.; Möbius, W.; Ruhwedel, T.; Katona, I.; Weis, J.; Klein, D.; Martini, R.; Brück, W.; Müller, W.C.; Bonn, S.; Bechmann, I.; Nave, K.-A.; Stassart, R. M.; Sereda, M. W.: Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy. Nature Communications 9, 3025 (2018)

Weil, M.-T.; Heibeck, S.; Töpperwien, M.; tom Dieck, S.; Ruhwedel, T.; Salditt, T.; Rodicio, M. C.; Morgan, J. R.; Nave, K.-A.; Möbius, W. et al.; Werner, H. B.: Axonal Ensheathment in the Nervous System of Lamprey: Implications for the Evolution of Myelinating Glia. The Journal of Neuroscience 38 (29), pp. 6586 - 6596 (2018)

Cantuti-Castelvetri, L.; Fitzner, D.; Bosch-Queralt, M.; Weil, M.-T.; Su, M.; Sen, P.; Ruhwedel, T.; Mitkovski, M.; Trendelenburg, G.; Lütjohann, D. et al.; Möbius, W.; Simons, M.: Defective cholesterol clearance limits remyelination in the aged central nervous system. Science 359 (6376), pp. 684 - 688 (2018)

Berghoff, S. A.; Düking, T.; Spieth, L.; Winchenbach, J.; Stumpf, S. K.; Gerndt, N.; Kusch, K.; Ruhwedel, T.; Möbius, W.; Saher, G.: Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model. Acta Neuropathologica Communications 5, 94 (2017)

Berghoff, S. A.; Gerndt, N.; Winchenbach, J.; Stumpf, S. K.; Hosang, L.; Odoardi, F.; Ruhwedel, T.; Böhler, C.; Barrette, B.; Stassart, R. et al.; Liebetanz, D.; Dibaj, P.; Möbius, W.; Edgar, J. M.; Saher, G.: Dietary cholesterol promotes repair of demyelinated lesions in the adult brain. Nature Communications 8, 14241 (2017)

Weil, M.-T.; Ruhwedel, T.; Möbius, W.; Simons, M.: Intracerebral injections and ultrastructural analysis of high-pressure frozen brain tissue. Current Protocols in Neuroscience 78, pp. 2.27.1 - 2.27.18 (2017)