Rhythms - Beating Cilia and Ticking Clocks
The big scale: We explore the potential role of circadian clocks in regulating the daily vertical migration of plankton in lakes and oceans. We use transcriptomics to identify candidate genes that link the planktonic clock to the translocation of plankton along the water column – a migration, sometimes over distances of hundreds of meters.
The small scale: We study translocation of naturally occurring nanoparticles (exosomes) inside our brain. Micrometer-size cilia bundles power and steer nanoparticle movement along elaborate pathways. Our focus is on the traffic rules of the transport system and on the physiological responses, the exosomes evoke once the reach their destination.