Max Planck Institute for Multidisciplinary Sciences

Publications

Journal Article (73)

1.

Journal Article

Roos, L.; Garrido-Charles, A.; Albrecht, N.; Vavakou, A.; Alekseev, A.; Bleyer, M.; Thirumalai, A.; Mittring, A.; Alvanos, T.; Huet, A. T. et al.; Bamberg, E.; Kusch, K.; Wolf, B. J.; Moser, T.; Mager, T.: Channelrhodopsin variants for high-rate optogenetic neurostimulation at low light intensities. EMBO Molecular Medicine (2025)

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2.

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Schwenzer, N.; Tsukanov, R.; Kohl, T.; Basak, S.; Sobitov, I.; Seibertz, F.; Kapoor, R.; Voigt, N.; Lehnart, S. E.: Nanoscale architecture and dynamics of Ca_V1.3 channel clusters in cardiac myocytes revealed by single channel nanoscopy. Journal of Molecular and Cellular Cardiology Plus 14, 100490 (2025)

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3.

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Aakhte, M.; Müller, G. F.; Roos, L.; Li, J.; Göpel, T.; Weiss, K. R.; Diniz, A. M.; Wenzel, J.; Schwaninger, M.; Moser, T. et al.; Huisken, J.: Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue. Nature Biotechnology (2025)

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4.

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Kapoor, R.; Kim, H.; Garlick, E.; Lima, M. A. d. R. B. F.; Esch, K.; Ruhwedel, T.; Möbius, W.; Wolf, F.; Moser, T.: Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy. Science Advances 11 (45), eady4344 (2025)

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5.

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Fan, X.; Gao, Z.; Zhong, J.; Chen, Y.; Chen, X.; Landegger, L. D.; Moser, T.; Zeng, F.-G.; Sun, Y.; Jin, X. et al.; Nash, R.; Chien, W. W.; Jiang, D.; Greinwald, J. H.; Bance, M.; Rodríguez, M. M.; Lee, S.-Y.; Feng, G.; Yang, H.; Wu, C.-C.; Xu, L.; Yuan, W.; Feng, Y.; Zhao, Y.; Vona, B.; Strenzke, N.; Beutner, D.; Amin, N.; Arwyn-Jones, J.; Chandrasekeharan, D.; Shi, D.; Zhang, D.; Yang, J.; Qi, J.; Wang, Q.; Yin, Y.; Cheng, Y.-F.; Tao, Y.; Yu, Y.; Wang, D.; Jiang, L.; Guo, L.; Chen, L.; Cheng, X.; Cui, C.; Lv, J.; Han, S.; Wang, W.; Li, Y.; Gao, X.; Liu, X. Z.; Zha, D.; Shi, H.; Chen, B.; Wang, Q.; Yuan, H.; Yang, S.; Yin, S.; Wu, H.; Wang, Z.; Li, H.; Rubinstein, J. T.; Lustig, L. R.; Chai, R.; Chen, Z.-Y.; Shu, Y.: International expert consensus on gene therapy for hereditary hearing loss: Based on clinical trials. Med, 100886 (2025)

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6.

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Karagulyan, N.; Überegger, M.; Qi, Y.; Babai, N.; Hofer, F.; Johnson Chacko, L.; Wang, F.; Luque, M.; Glueckert, R.; Schrott-Fischer, A. et al.; Hua, Y.; Moser, T.; Bandtlow, C.: Probing the role of synaptic adhesion molecule RTN4RL2 in setting up cochlear connectivity. eLife 14, RP103481 (2025)

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7.

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Chen, H.; Cretu, C.; Trebilcock, A.; Evdokimova, N.; Babai, N.; Feldmann, L.; Leidner, F.; Benseler, F.; Mutschall, S.; Esch, K. et al.; Szabo, C. Z. K.; Pena, V.; Pape, C.; Grubmüller, H.; Strenzke, N.; Brose, N.; Wichmann, C.; Preobraschenski, J.; Moser, T.: Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing. Science Advances 11 (42), eady8532 (2025)

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8.

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Muth, S.; Moschref, F.; Freckmann, L.; Mutschall, S.; Hojas-Garcia-Plaza, I.; Bahr, J. N.; Petrovic, A.; Do, T. T.; Schwarze, V.; Archit, A. et al.; Weyand, K.; Michanski, S.; Maus, L.; Imig, C.; Hintze, A.; Brose, N.; Wichmann, C.; Fernandez-Busnadiego, R.; Moser, T.; Rizzoli, S. O.; Cooper, B. H.; Pape, C.: SynapseNet: Deep Learning for Automatic Synapse Reconstruction. Molecular Biology of the Cell 36 (10), ar127 (2025)

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9.

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Shaib, A. H.; Chouaib, A. A.; Chowdhury, R.; Altendorf, J.; Mihaylov, D.; Zhang, C.; Krah, D.; Imani, V.; Spencer, R. K. W.; Georgiev, S. V. et al.; Mougios, N.; Monga, M.; Reshetniak, S.; Mimoso, T.; Chen, H.; Fatehbasharzad, P.; Crzan, D.; Saal, K.-A.; Alawieh, M. M.; Alawar, N.; Eilts, J.; Kang, J.; Soleimani, A.; Müller, M.; Pape, C.; Alvarez, L.; Trenkwalder, C.; Mollenhauer, B.; Outeiro, T. F.; Köster, S.; Preobraschenski, J.; Becherer, U.; Moser, T.; Boyden, E. S.; Aricescu, A. R.; Sauer, M.; Opazo, F.; Rizzoli, S. O.: One-step nanoscale expansion microscopy reveals individual protein shapes. Nature Biotechnology 43, pp. 1539 - 1547 (2025)

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10.

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Vona, B.; Wollnik, B.; Strenzke, N.; Pangršič, T.; Moser, T.: Is CABP2-Associated Hearing Loss (DFNB93) a Gene Therapy Target? Preclinical Progress and Patient Registry. MedComm 6 (9), e70363 (2025)

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11.

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Jablonski, L.; Harczos, T.; Wolf, B.; Hoch, G.; Khurana, L.; Dieter, A.; Roos, L.; Hessler, R.; Ayub, S.; Ruther, P. et al.; Moser, T.: Hearing restoration by a low-weight power-efficient multichannel optogenetic cochlear implant system. Journal of Neural Engineering 22 (4), 046034 (2025)

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12.

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Alekseev, A.; Hunniford, V.; Zerche, M.; Jeschke, M.; El May, F.; Vavakou, A.; Siegenthaler, D.; Hüser, M. A.; Kiehn, S. M.; Garrido-Charles, A. et al.; Meyer, A.; Rambousky, A.; Alvanos, T.; Witzke, I.; Rojas-Garcia, K. D.; Draband, M. D.; Cyganek, L.; Klein, E.; Ruther, P.; Huet, A.; Trenholm, S.; Macé, E.; Kusch, K.; Bruegmann, T.; Wolf, B. J.; Mager, T.; Moser, T.: Efficient and sustained optogenetic control of sensory and cardiac systems. Nature Biomedical Engineering (2025)

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13.

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Cretu, C.; Chernev, A.; Szabó, C. Z. K.; Pena, V.; Urlaub, H.; Moser, T.; Preobraschenski, J.: Structural insights into lipid membrane binding by human ferlins. The EMBO Journal 44 (14), pp. 3926 - 3958 (2025)

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14.

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Moser, T.; Roos, L.: Toward elucidating the mechanism of cochlear stimulation by infrared light. Proceedings of the National Academy of Sciences of the United States of America 122 (22), e2507582122 (2025)

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Karagulyan, N.; Thirumalai, A.; Michanski, S.; Qi, Y.; Fang, Q.; Wang, H.; Ortner, N. J.; Striessnig, J.; Strenzke, N.; Wichmann, C. et al.; Hua, Y.; Moser, T.: Gating of hair cell Ca²⁺ channels governs the activity of cochlear neurons. Science Advances 11 (25), eadu7898 (2025)

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16.

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Groshkova, M.; Alvanos, T.; Qi, Y.; Wang, F.; Wichmann, C.; Hua, Y.; Moser, T.: Investigation of neuromodulation of the endbulb of Held synapse in the cochlear nucleus by serotonin and norepinephrine. Frontiers in Cellular Neuroscience 19, 1575158 (2025)

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17.

Journal Article

Thirumalai, A.; Henseler, J.; Enayati, M.; Kusch, K.; Hessler, R.; Moser, T.; Huet, A. T.: Improved optogenetic modification of spiral ganglion neurons for future optical cochlear implants. Theranostics 15 (10), pp. 4270 - 4286 (2025)

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18.

Journal Article

Schaeper, J. J.; Kampshoff, C. A.; Wolf, B. J.; Roos, L.; Michanski, S.; Ruhwedel, T.; Eckermann, M.; Meyer, A.; Jeschke, M.; Wichmann, C. et al.; Moser, T.; Salditt, T.: 3D virtual histology of rodent and primate cochleae with multi-scale phase-contrast X-ray tomography. Scientific Reports 15, 7933 (2025)

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19.

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Oestreicher, D.; Malpede, A. M.; Reitmeier, A.; Bräuer, C. P.; Schoch, L.; Strenzke, N.; Pangrsic, T.: Noise-induced ribbon synapse loss in the mouse basal cochlear region does not reduce inner hair cell exocytosis. Frontiers in Cellular Neuroscience 18, 1523978 (2025)

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20.

Journal Article

Lamm, G. H. U.; Marin, E.; Alekseev, A.; Schellbach, A. V.; Stetsenko, A.; Haro-Moreno, J. M.; Bourenkov, G.; Borshchevskiy, V.; Asido, M.; Agthe, M. et al.; Engilberge, S.; Rose, S. L.; Caramello, N.; Royant, A.; Schneider, T. R.; Bateman, A.; Mager, T.; Moser, T.; Rodriguez-Valera, F.; Wachtveitl, J.; Guskov, A.; Kovalev, K.: CryoRhodopsins: A comprehensive characterization of a group of microbial rhodopsins from cold environments. Science Advances 11 (27), eadv1015 (2025)

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21.

Journal Article

Jaime Tobón, L. M.; Moser, T.: Bridging the gap between presynaptic hair cell function and neural sound encoding. eLife 12, RP93749 (2024)

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22.

Journal Article

Oestreicher, D.; Chepurwar, S.; Kusch, K.; Rankovic, V.; Jung, S.; Strenzke, N.; Pangrsic, T.: CaBP1 and 2 enable sustained Ca_V1.3 calcium currents and synaptic transmission in inner hair cells. eLife 13, RP93646 (2024)

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23.

Journal Article

Vona, B.; Wollnik, B.; Strenzke, N.; Moser, T.: Catching up but still miles behind—a patient registry for otoferlin. Experimental and Molecular Medicine 56, pp. 1472 - 1473 (2024)

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24.

Journal Article

Chen, H.; Monga, M.; Fang, Q.; Slitin, L.; Neef, J.; Chepurwar, S. S.; Netto, R. C. M.; Lezirovitz, K.; Tabith Jr, A.; Benseler, F. et al.; Brose, N.; Kusch, K.; Wichmann, C.; Strenzke, N.; Vona, B.; Preobraschenski, J.; Moser, T.: Ca²⁺ binding to the C₂E domain of otoferlin is required for hair cell exocytosis and hearing. Protein & Cell 15 (4), pp. 305 - 312 (2024)

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25.

Journal Article

Hain, P. J. H.; Moser, T.: Optical measurement of glutamate release robustly reports short-term plasticity at a fast central synapse. Frontiers in Molecular Neuroscience 17, 1351280 (2024)

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26.

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Cepeda, A. P.; Ninov, M.; Neef, J.; Parfentev, I.; Kusch, K.; Reisinger, E.; Jahn, R.; Moser, T.; Urlaub, H.: Proteomic Analysis Reveals the Composition of Glutamatergic Organelles of Auditory Inner Hair Cells. Molecular & Cellular Proteomics 23 (2), 100704 (2024)

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27.

Journal Article

Huet, A.; Mager, T.; Gossler, C.; Moser, T.: Toward Optogenetic Hearing Restoration. Annual Review of Neuroscience 47, pp. 103 - 121 (2024)

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28.

Journal Article

Chen, H.; Fang, Q.; Benseler, F.; Brose, N.; Moser, T.: Probing the role of the C₂F domain of otoferlin. Frontiers in Molecular Neuroscience 16, 1299509 (2023)

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29.

Journal Article

Moser, T.; Karagulyan, N.; Neef, J.; Jaime Tobón, L. M.: Diversity matters — extending sound intensity coding by inner hair cells via heterogeneous synapses. The EMBO Journal 42 (23), e114587 (2023)

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30.

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Khurana, L.; Harczos, T.; Moser, T.; Jablonski, L.: En route to sound coding strategies for optical cochlear implants. iScience 26 (10), 107725 (2023)

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31.

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Karagulyan, N.; Moser, T.: Synaptic activity is not required for establishing heterogeneity of inner hair cell ribbon synapses. Frontiers in Molecular Neuroscience 16, 1248941 (2023)

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32.

Journal Article

Michanski, S.; Kapoor, R.; Steyer, A. M.; Möbius, W.; Früholz, I.; Ackermann, F.; Gueltas, M.; Garner, C. C.; Hamra, F. K.; Neef, J. et al.; Strenzke, N.; Moser, T.; Wichmann, C.: Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing. EMBO Reports 24 (9), e56702 (2023)

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33.

Journal Article

Grabner, C.; Futagi, D.; Shi, J.; Bindokas, V.; Kitano, K.; Schwartz, E.A.; DeVries, S.H.: Mechanisms of simultaneous linear and nonlinear computations at the mammalian cone photoreceptor synapse. Nature Communications 14, 3486 (2023)

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34.

Journal Article

Zerche, M.; Wrobel, C.; Kusch, K.; Moser, T.; Mager, T.: Channelrhodopsin fluorescent tag replacement for clinical translation of optogenetic hearing restoration. Molecular Therapy: Methods & Clinical Development 29, pp. 202 - 212 (2023)

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35.

Journal Article

Hunniford, V.; Kuehler, R.; Wolf, B.; Keppeler, D.; Strenzke, N.; Moser, T.: Patient perspectives on the need for improved hearing rehabilitation: A qualitative survey study of German cochlear implant users. Frontiers in Neuroscience 17, 1105562 (2023)

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36.

Journal Article

Cantu-Guerra, H. L.; Papazian, M. R.; Gorsky, A. L.; Alekos, N. S.; Caccavano, A.; Karagulyan, N.; Neef, J.; Vicini, S.; Moser, T.; Coate, T. M.: Cochlear hair cell innervation is dependent on a modulatory function of Semaphorin-3A. Developmental Dynamics 252 (1), pp. 124 - 144 (2023)

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37.

Journal Article

Jaime Tobón, L. M.; Moser, T.: Ca²⁺ regulation of glutamate release from inner hair cells of hearing mice. Proceedings of the National Academy of Sciences of the United States of America 120 (49), e2311539120 (2023)

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38.

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Michael, M.; Wolf, B. J.; Klinge-Strahl, A.; Jeschke, M.; Moser, T.; Dieter, A.: Devising a framework of optogenetic coding in the auditory pathway: Insights from auditory midbrain recordings. Brain Stimulation 16 (5), pp. 1486 - 1500 (2023)

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39.

Journal Article

Mittring, A.; Moser, T.; Huet, A. T.: Graded optogenetic activation of the auditory pathway for hearing restoration. Brain Stimulation 16 (2), pp. 466 - 483 (2023)

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40.

Journal Article

Chakrabarti, R.; Jaime Tobon, L. M.; Slitin, L.; Redondo-Canales, M.; Hoch, G.; Slashcheva, M.; Fritsch, E.; Bodensiek, K.; Özçete, Ö. D.; Gültas, M. et al.; Michanski, S.; Opazo, F.; Neef, J.; Pangrsic, T.; Moser, T.; Wichmann, C.: Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses. eLife 11, e79494 (2022)

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41.

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Bosse, N. I.; Abbott, S.; Bracher, J.; Hain, H.; Quilty, B. J.; Jit, M.; Centre for the Mathematical Modelling of Infectious Diseases COVID-19 Working Group; van Leeuwen, E.; Cori, A.; Funk, S.: Comparing human and model-based forecasts of COVID-19 in Germany and Poland. PLoS Computational Biology 18 (9), e1010405 (2022)

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42.

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Wolf, B. J.; Kusch, K.; Hunniford, V.; Vona, B.; Kuhler, R.; Keppeler, D.; Strenzke, N.; Moser, T.: Is there an unmet medical need for improved hearing restoration? Embo Molecular Medicine 14 (8), e15798 (2022)

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43.

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Grabner, C.; Jansen, I.; Neef, J.; Weihs, T.; Schmidt, R.; Riedel, D.; Wurm, C. A.; Moser, T.: Resolving the molecular architecture of the photoreceptor active zone with 3D-MINFLUX. Science Advances 8 (28), eabl7560 (2022)

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44.

Journal Article

Calapai, A.; Cabrera-Moreno, J.; Moser, T.; Jeschke, M.: Flexible auditory training, psychophysics, and enrichment of common marmosets with an automated, touchscreen-based system. Nature Communications 13 (1), 1648 (2022)

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45.

Journal Article

Khurana, L.; Keppeler, D.; Jablonski, L.; Moser, T.: Model-based prediction of optogenetic sound encoding in the human cochlea by future optical cochlear implants. Computational and Structural Biotechnology Journal 20, pp. 3621 - 3629 (2022)

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46.

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Butola, T.; Alvanos, T.; Hintze, A.; Koppensteiner, P.; Kleindienst, D.; Shigemoto, R.; Wichmann, C.; Moser, T.: RIM-Binding Protein 2 organizes Ca2+channel topography and regulates release probability and vesicle replenishment at a fast central synapse. bioRxiv, 435607 (2021)

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47.

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Özçete, Ö. D.; Moser, T.: A sensory cell diversifies its output by varying Ca2+ influx‐release coupling among active zones. EMBO Journal 40 (5), e106010 (2021)

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48.

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Rankovic, V.; Vogl, C.; Dörje, N. M.; Bahader, I.; Duque-Afonso, C. J.; Thirumalai, A.; Weber, T.; Kusch, K.; Strenzke, N.; Moser, T.: Overloaded adeno-associated virus as a novel gene therapeutic tool for otoferlin-related deafness. Frontiers in Moecular Neuroscience 13, 600051 (2021)

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49.

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Grabner, C.; Moser, T.: The mammalian rod synaptic ribbon is essential for Cav channel facilitation and ultrafast fusion of the readily releasable pool of vesicles. bioRxiv, 336503 (2020)

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50.

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Keppeler, D.; Schwaerzle, M.; Harczos, T.; Jablonski, L.; Dieter, A.; Wolf, B.; Ayub, S.; Vogl, C.; Wrobel, C.; Hoch, G. et al.; Abdellatif, K.; Jeschke, M.; Rankovic, V.; Paul, O.; Ruther, P.; Moser, T.: Multichannel optogenetic stimulation of the auditory pathway using microfabricated LED cochlear implants in rodents. Science Translational Medicine 12 (553), eabb8086 (2020)

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