Publikationen

2.

Zeitschriftenartikel

Donath, T.; Šišak Jung, D.; Burian, M.; Radicci, V.; Zambon, P.; Fitch, A. N.; Dejoie, C.; Zhang, B.; Ruat, M.; Hanfland, M. et al.; Kewish, C. M.; van Riessen, G. A.; Naumenko, D.; Amenitsch, H.; Bourenkov, G.; Bricogne, G.; Chari, A.; Schulze-Briese, C.: EIGER2 hybrid-photon-counting X-ray detectors for advanced synchrotron diffraction experiments. Journal of Synchrotron Radiation, 30 (2023)

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3.

Zeitschriftenartikel

Yi, S.-H.; Petrychenko, V.; Schliep, J. E.; Goyal, A.; Linden, A.; Chari, A.; Urlaub, H.; Stark, H.; Rodnina, M. V.; Adio, S. et al.; Fischer, N.: Conformational rearrangements upon start codon recognition in human 48S translation initiation complex. Nucleic Acids Research 50 (9), S. 5282 - 5298 (2022)

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4.

Zeitschriftenartikel

Henneberg, F.; Chari, A.: Chromatography-free purification strategies for large biological macromolecular complexes involving fractionated PEG precipitation and density gradients. Life 11, 1289 (2021)

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5.

Zeitschriftenartikel

Henneberg, F.; Chari, A.: Chromatography-free purification strategies for large biological macromolecular complexes involving fractionated PEG precipitation and density gradients. Life 11 (12), 1289 (2021)

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6.

Zeitschriftenartikel

Yip, K. M.; Fischer, N.; Paknia, E.; Chari, A.; Stark, H.: Atomic-resolution protein structure determination by cryo-EM. Nature 587 (7832), S. 157 - 161 (2020)

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7.

Zeitschriftenartikel

Ukmar-Godec, T.; Fang, P.; Ibáñez de Opakua, A.; Henneberg, F.; Godec, A.; Pan, K. T.; Cima-Omori, M.-S.; Chari, A.; Mandelkow, E.; Urlaub, H. et al.; Zweckstetter, M.: Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution. Science Advances 6 (30), eaba3916 (2020)

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8.

Zeitschriftenartikel

Singh, K.; Graf, B.; Linden, A.; Sautner, V.; Urlaub, H.; Tittmann, K.; Stark, H.; Chari, A.: Discovery of a regulatory subunit of the yeast fatty acid synthase. Cell 180 (6), S. 1130 - 1143.e20 (2020)

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9.

Zeitschriftenartikel

Prajapati, S.; Haselbach, D.; Wittig, S.; Patel, M. S.; Chari, A.; Schmidt, C.; Stark, H.; Tittmann, K.: Structural and functional analyses of the human PDH complex suggest a "Division-of-Labor" mechanism by local E1 and E3 clusters. Structure 27 (7), S. 1124 - 1136 (2019)

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10.

Zeitschriftenartikel

Renaud, J. P.; Chari, A.; Ciferri, C.; Liu, W.; Rémigy, H. W.; Stark, H.; Wiesmann, C.: Cryo-EM in drug discovery: Achievements, limitations and prospects. Nature Reviews Drug Discovery 17 (7), S. 471 - 492 (2018)

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11.

Zeitschriftenartikel

Haselbach, D.; Schrader, J.; Lambrecht, F.; Henneberg, F.; Chari, A.; Stark, H.: Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs. Nature Communications 8, 15578 (2017)

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12.

Zeitschriftenartikel

Rauhut, R.; Fabrizio, P.; Dybkov, O.; Hartmuth, K.; Pena, V.; Chari, A.; Kumar, V.; Lee, C. T.; Urlaub, H.; Kastner, B. et al.; Stark, H.; Lührmann, R.: Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Science 353 (6306), S. 1399 - 1405 (2016)

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13.

Zeitschriftenartikel

Paknia, E.; Chari, A.; Stark, H.; Fischer, U.: The ribosome cooperates with the assembly chaperone pICln to initiate formation of snRNPs. Cell Reports 16 (12), S. 3103 - 3112 (2016)

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14.

Zeitschriftenartikel

Schrader, J.; Henneberg, F.; Mata, R. A.; Tittmann, K.; Schneider, T. R.; Stark, H.; Bourenkov, G.; Chari, A.: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science 353 (6299), S. 594 - 598 (2016)

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15.

Zeitschriftenartikel

Stark, H.; Chari, A.: Sample preparation of biological macromolecular assemblies for the determination of high-resolution structures by cryo-electron microscopy. Microscopy 65 (1), S. 23 - 34 (2016)

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16.

Zeitschriftenartikel

Chari, A.; Haselbach, D.; Kirves, J. M.; Ohmer, J.; Paknia, E.; Fischer, N.; Ganichkin, O.; Moller, V.; Frye, J. J.; Petzold, G. et al.; Jarvis, M.; Tietzel, M.; Grimm, C.; Peters, J. M.; Schulman, B. A.; Tittmann, K.; Markl, J.; Fischer, U.; Stark, H.: ProteoPlex: Stability optimization of macromolecular complexes by sparse-matrix screening of chemical space. Nature Methods 12 (9), S. 859 - 865 (2015)

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17.

Zeitschriftenartikel

Neuenkirchen, N.; Englbrecht, C.; Ohmer, J.; Ziegenhals, T.; Chari, A.; Fischer, U.: Reconstitution of the human U snRNP assembly machinery reveals stepwise Sm protein organization. EMBO Journal 34 (14), S. 1925 - 1941 (2015)

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18.

Zeitschriftenartikel

Fischer, U.; Chari, A.: Assembly of RNPs: help needed. RNA 21 (4), S. 613 - 614 (2015)

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19.

Zeitschriftenartikel

Husedzinovic, A.; Neumann, B.; Reymann, J.; Draeger-Meurer, S.; Chari, A.; Erfle, H.; Fischer, U.; Gruss, O. J.: The catalytically inactive tyrosine phosphatase HD-PTP/PTPN23 is a novel regulator of SMN complex localization. Molecular Biology of the Cell 26 (2), S. 161 - 171 (2015)

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20.

Zeitschriftenartikel

Liu, Y.; Neumann, P.; Kuhle, B.; Monecke, T.; Schell, S.; Chari, A.; Ficner, R.: Translation initiation factor eIF3b contains a nine-bladed beta-propeller and interacts with the 40S ribosomal subunit. Structure 22 (6), S. 923 - 930 (2014)

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21.

Zeitschriftenartikel

Husedzinovic, A.; Oppermann, F.; Draeger-Meurer, S.; Chari, A.; Fischer, U.; Daub, H.; Gruss, O. J.: Phosphoregulation of the human SMN complex. European Journal of Cell Biology 93 (3), S. 106 - 117 (2014)

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22.

Zeitschriftenartikel

Grimm, C.; Chari, A.; Pelz, J. P.; Kuper, J.; Kisker, C.; Diederichs, K.; Stark, H.; Schindelin, H.; Fischer, U.: Structural basis of assembly chaperone- mediated snRNP formation. Molecular Cell 49 (4), S. 692 - 703 (2013)

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23.

Zeitschriftenartikel

Fischer, U.; Englbrecht, C.; Chari, A.: Biogenesis of spliceosomal small nuclear ribonucleoproteins. Wiley Interdisciplinary Reviews: RNA 2 (5), S. 718 - 731 (2011)

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24.

Zeitschriftenartikel

Chari, A.; Fischer, U.: Cellular strategies for the assembly of molecular machines. Trends in biochemical sciences 35 (12), S. 676 - 683 (2010)

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25.

Zeitschriftenartikel

Martin, G.; Ostareck-Lederer, A.; Chari, A.; Neuenkirchen, N.; Dettwiler, S.; Blank, D.; Rüegsegger, U.; Fischer, U.; Keller, W.: Arginine methylation in subunits of mammalian pre-mRNA cleavage factor I. RNA 16 (8), S. 1646 - 1659 (2010)

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26.

Zeitschriftenartikel

Grimm, C.; Chari, A.; Reuter, K.; Fischer, U.: A crystallization screen based on alternative polymeric precipitants. Acta Crystallographica Section D 66 (6), S. 685 - 697 (2010)

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27.

Zeitschriftenartikel

Galão, R. P.; Chari, A.; Alves-Rodrigues, I.; Lobão, D.; Mas, A.; Kambach, C.; Fischer, U.; Díez, J.: LSm1-7 complexes bind to specific sites in viral RNA genomes and regulate their translation and replication. RNA 16 (4), S. 817 - 827 (2010)

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28.

Zeitschriftenartikel

Scheller, N.; Mina, L. B.; Galão, R. P.; Chari, A.; Giménez-Barcons, M.; Noueiry, A.; Fischer, U.; Meyerhans, A.; Díez, J.: Translation and replication of hepatitis C virus genomic RNA depends on ancient cellular proteins that control mRNA fates. Proceedings of the National Academy of Sciences of the USA 106 (32), S. 13517 - 13522 (2009)

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29.

Zeitschriftenartikel

Chari, A.; Paknia, E.; Fischer, U.: The role of RNP biogenesis in spinal muscular atrophy. Current Opinion in Cell Biology 21 (3), S. 387 - 393 (2009)

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30.

Zeitschriftenartikel

Guenther, U.-P.; Handoko, L.; Laggerbauer, B.; Jablonka, S.; Chari, A.; Alzheimer, M.; Ohmer, J.; Plöttner, O.; Gehring, N.; Sickmann, A. et al.; von Au, K.; Schuelke, M.; Fischer, U.: IGHMBP2 is a ribosome-associated helicase inactive in the neuromuscular disorder distal SMA type 1 (DSMA1). Human Molecular Genetics 18 (7), S. 1288 - 1300 (2009)

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31.

Zeitschriftenartikel

Chari, A.; Fischer, U.: Molekulares Bodybuilding: Wie Zellen RNA-Proteinkomplexe herstellen. BioSpektrum 15 (5), S. 484 - 487 (2009)

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32.

Zeitschriftenartikel

Chari, A.; Golas, M. M.; Klingenhaeger, M.; Neuenkirchen, N.; Sander, B.; Englbrecht, C.; Sickmann, A.; Stark, H.; Fischer, U.: An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. Cell 135 (3), S. 497 - 509 (2008)

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33.

Zeitschriftenartikel

Kroiss, M.; Schultz, J.; Wiesner, J.; Chari, A.; Sickmann, A.; Fischer, U.: Evolution of an RNP assembly system: A minimal SMN complex facilitates formation of UsnRNPs in Drosophila melanogaster. Proceedings of the National Academy of Sciences of the USA 105 (29), S. 10045 - 10050 (2008)

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34.

Zeitschriftenartikel

Neuenkirchen, N.; Chari, A.; Fischer, U.: Deciphering the assembly pathway of Sm‐class U snRNPs. FEBS Letters 582 (14), S. 1997 - 2003 (2008)

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35.

Zeitschriftenartikel

Menzel, N.; Chari, A.; Fischer, U.; Linder, M.; Raabe, T.: A 5′-fluorosulfonylbenzoyladenosine-based method to identify physiological substrates of a Drosophila p21-activated kinase. Analytical Biochemistry 368 (2), S. 178 - 184 (2007)

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36.

Zeitschriftenartikel

Otter, S.; Grimmler, M.; Neuenkirchen, N.; Chari, A.; Sickmann, A.; Fischer, U.: A comprehensive interaction map of the human survival of motor neuron (SMN) complex. Journal of Biological Chemistry 282 (8), S. 5825 - 5833 (2007)

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37.

Zeitschriftenartikel

Fischer, U.; Kroiss, M.; Chari, A.: Wenn Muskeln die Nerven verlieren. Biospektrum 13 (6), S. 610 - 613 (2007)

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38.

Zeitschriftenartikel

Eggert, C.; Chari, A.; Laggerbauer, B.; Fischer, U.: Spinal muscular atrophy: the RNP connection. Trends in Molecular Medicine 12 (3), S. 113 - 121 (2006)

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39.

Zeitschriftenartikel

Grimmler, M.; Otter, S.; Peter, C.; Müller, F.; Chari, A.; Fischer, U.: Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization. Human Molecular Genetics 14 (20), S. 3099 - 3111 (2005)

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40.

Zeitschriftenartikel

Azzouz, T. N.; Pillai, R. S.; Däpp, C.; Chari, A.; Meister, G.; Kambach, C.; Fischer, U.; Schümperli, D.: Toward an assembly line for U7 snRNPs - Interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes. Journal of Biological Chemistry 280 (41), S. 34435 - 34440 (2005)

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