Publikationen
Zeitschriftenartikel (46)
1.
Zeitschriftenartikel
Peptide bonds strike back. IUCrJ 12 (Part 3), 12 (2025)
2.
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Blm10-Based Compounds Add to the Knowledge of How Allosteric Modulators Influence Human 20S Proteasome. ACS Chemical Biology 20 (2), S. 266 - 280 (2025)
3.
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Protein degradation by human 20S proteasomes elucidates the interplay between peptide hydrolysis and splicing. Nature Communications 15 (1), 1147 (2024)
4.
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Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design. Nature Communications 15, 411 (2024)
5.
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Prospects and Limitations of High-Resolution Single-Particle Cryo-Electron Microscopy. Annual Review of Biophysics 52, S. 391 - 411 (2023)
6.
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EIGER2 hybrid-photon-counting X-ray detectors for advanced synchrotron diffraction experiments. Journal of Synchrotron Radiation, S. 723 - 738 (2023)
7.
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Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell 186 (23), e16, S. 5054 - 5067 (2023)
8.
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Conformational rearrangements upon start codon recognition in human 48S translation initiation complex. Nucleic Acids Research 50 (9), S. 5282 - 5298 (2022)
9.
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Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5′-monophosphate decarboxylase catalysis. Nature Catalysis 5, S. 332 - 341 (2022)
10.
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Chromatography-free purification strategies for large biological macromolecular complexes involving fractionated PEG precipitation and density gradients. Life 11, 1289 (2021)
11.
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Chromatography-free purification strategies for large biological macromolecular complexes involving fractionated PEG precipitation and density gradients. Life 11 (12), 1289 (2021)
12.
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Atomic-resolution protein structure determination by cryo-EM. Nature 587 (7832), S. 157 - 161 (2020)
13.
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Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution. Science Advances 6 (30), eaba3916 (2020)
14.
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Discovery of a regulatory subunit of the yeast fatty acid synthase. Cell 180 (6), S. 1130 - 1143.e20 (2020)
15.
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Structural and functional analyses of the human PDH complex suggest a "Division-of-Labor" mechanism by local E1 and E3 clusters. Structure 27 (7), S. 1124 - 1136 (2019)
16.
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Cryo-EM in drug discovery: Achievements, limitations and prospects. Nature Reviews Drug Discovery 17 (7), S. 471 - 492 (2018)
17.
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Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs. Nature Communications 8, 15578 (2017)
18.
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Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Science 353 (6306), S. 1399 - 1405 (2016)
19.
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The ribosome cooperates with the assembly chaperone pICln to initiate formation of snRNPs. Cell Reports 16 (12), S. 3103 - 3112 (2016)
20.
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The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science 353 (6299), S. 594 - 598 (2016)
21.
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Sample preparation of biological macromolecular assemblies for the determination of high-resolution structures by cryo-electron microscopy. Microscopy 65 (1), S. 23 - 34 (2016)
22.
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ProteoPlex: Stability optimization of macromolecular complexes by sparse-matrix screening of chemical space. Nature Methods 12 (9), S. 859 - 865 (2015)
23.
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Reconstitution of the human U snRNP assembly machinery reveals stepwise Sm protein organization. EMBO Journal 34 (14), S. 1925 - 1941 (2015)
24.
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Assembly of RNPs: help needed. RNA 21 (4), S. 613 - 614 (2015)
25.
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The catalytically inactive tyrosine phosphatase HD-PTP/PTPN23 is a novel regulator of SMN complex localization. Molecular Biology of the Cell 26 (2), S. 161 - 171 (2015)
26.
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Translation initiation factor eIF3b contains a nine-bladed beta-propeller and interacts with the 40S ribosomal subunit. Structure 22 (6), S. 923 - 930 (2014)
27.
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Phosphoregulation of the human SMN complex. European Journal of Cell Biology 93 (3), S. 106 - 117 (2014)
28.
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Structural basis of assembly chaperone- mediated snRNP formation. Molecular Cell 49 (4), S. 692 - 703 (2013)
29.
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Biogenesis of spliceosomal small nuclear ribonucleoproteins. Wiley Interdisciplinary Reviews: RNA 2 (5), S. 718 - 731 (2011)
30.
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Cellular strategies for the assembly of molecular machines. Trends in biochemical sciences 35 (12), S. 676 - 683 (2010)
31.
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Arginine methylation in subunits of mammalian pre-mRNA cleavage factor I. RNA 16 (8), S. 1646 - 1659 (2010)
32.
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A crystallization screen based on alternative polymeric precipitants. Acta Crystallographica Section D 66 (6), S. 685 - 697 (2010)
33.
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LSm1-7 complexes bind to specific sites in viral RNA genomes and regulate their translation and replication. RNA 16 (4), S. 817 - 827 (2010)
34.
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Translation and replication of hepatitis C virus genomic RNA depends on ancient cellular proteins that control mRNA fates. Proceedings of the National Academy of Sciences of the USA 106 (32), S. 13517 - 13522 (2009)
35.
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The role of RNP biogenesis in spinal muscular atrophy. Current Opinion in Cell Biology 21 (3), S. 387 - 393 (2009)
36.
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IGHMBP2 is a ribosome-associated helicase inactive in the neuromuscular disorder distal SMA type 1 (DSMA1). Human Molecular Genetics 18 (7), S. 1288 - 1300 (2009)
37.
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Molekulares Bodybuilding: Wie Zellen RNA-Proteinkomplexe herstellen. BioSpektrum 15 (5), S. 484 - 487 (2009)
38.
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An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. Cell 135 (3), S. 497 - 509 (2008)
39.
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Evolution of an RNP assembly system: A minimal SMN complex facilitates formation of UsnRNPs in Drosophila melanogaster. Proceedings of the National Academy of Sciences of the USA 105 (29), S. 10045 - 10050 (2008)
40.
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Deciphering the assembly pathway of Sm‐class U snRNPs. FEBS Letters 582 (14), S. 1997 - 2003 (2008)
41.
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A 5′-fluorosulfonylbenzoyladenosine-based method to identify physiological substrates of a Drosophila p21-activated kinase. Analytical Biochemistry 368 (2), S. 178 - 184 (2007)
42.
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A comprehensive interaction map of the human survival of motor neuron (SMN) complex. Journal of Biological Chemistry 282 (8), S. 5825 - 5833 (2007)
43.
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Wenn Muskeln die Nerven verlieren. Biospektrum 13 (6), S. 610 - 613 (2007)
44.
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Spinal muscular atrophy: the RNP connection. Trends in Molecular Medicine 12 (3), S. 113 - 121 (2006)
45.
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Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization. Human Molecular Genetics 14 (20), S. 3099 - 3111 (2005)
46.
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Toward an assembly line for U7 snRNPs - Interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes. Journal of Biological Chemistry 280 (41), S. 34435 - 34440 (2005)
Buchkapitel (1)
47.
Buchkapitel
Fatty Acid Synthase: Structure, Function, and Regulation. In: Macromolecular Protein Complexes IV: Structure and Function, S. 1 - 33 (Hg. Harris, R.; Marles-Wright, J.). Springer, Cham (2022)