Publications

Kaji, S.; Berghoff, S. A.; Spieth, L.; Schlaphoff, L.; Sasmita, A. O.; Vitale, S.; Büschgens, L.; Kedia, S.; Zirngibl, M.; Nazarenko, T. et al.; Damkou, A.; Hosang, L.; Depp, C.; Kamp, F.; Scholz, P.; Ewers, D.; Giera, M.; Ischebeck, T.; Wurst, W.; Wefers, B.; Schifferer, M.; Willem, M.; Nave, K.-A.; Haass, C.; Arzberger, T.; Jäkel, S.; Wirths, O.; Saher, G.; Simons, M.: Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis. Immunity 57 (11), pp. 2651 - 2668.e12 (2024)

da Silva Correia, A.; Schmitz, M.; Fischer, A.; da Silva Correia, S.; Simonetti, F. L.; Saher, G.; Goya‐Maldonado, R.; Arora, A. S.; Fischer, A.; Outeiro, T. F. et al.; Zerr, I.: Cellular prion protein acts as mediator of amyloid beta uptake by caveolin‐1 causing cellular dysfunctions in vitro and in vivo. Alzheimer's & Dementia 20 (10), pp. 6776 - 6792 (2024)

Sasmita, A. O.; Depp, C.; Nazarenko, T.; Sun, T.; Siems, S. B.; Ong, E. C.; Nkeh, Y. B.; Böhler, C.; Yu, X.; Bues, B. et al.; Evangelista, L.; Mao, S.; Morgado, B.; Wu, Z.; Ruhwedel, T.; Subramanian, S.; Börensen, F.; Overhoff, K.; Spieth, L.; Berghoff, S. A.; Sadleir, K. R.; Vassar, R.; Eggert, S.; Goebbels, S.; Saito, T.; Saido, T.; Saher, G.; Möbius, W.; Castelo-Branco, G.; Klafki, H.-W.; Wirths, O.; Wiltfang, J.; Jäkel, S.; Yan, R.; Nave, K.-A.: Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice. Nature Neuroscience 27, pp. 1668 - 1674 (2024)

Nkeh, Y. B.; Elgin, R. G.; Saher, G.: From the unknown to spotlight: newly identified hormone adjusts hepatic cholesterol synthesis to dietary uptake. Signal Transduction and Targeted Therapy 9, 165 (2024)

Späte, E.; Zhou, B.; Sun, T.; Kusch, K.; Asadollahi, E.; Siems, S. B.; Depp, C.; Werner, H. B.; Saher, G.; Hirrlinger, J. et al.; Möbius, W.; Nave, K.-A.; Göbbels, S.: Downregulated expression of lactate dehydrogenase in adult oligodendrocytes and its implication for the transfer of glycolysis products to axons. Glia 72 (8), pp. 1374 - 1391 (2024)

Krauter, D.; Stausberg, D.; Hartmann, T. J.; Volkmann, S.; Kungl, T.; Rasche, D. A.; Saher, G.; Fledrich, R.; Stassart, R.M.; Nave, K.-A. et al.; Göbbels, S.; Ewers, D.; Sereda, M. W.: Targeting PI3K/Akt/mTOR signaling in rodent models of PMP22 gene-dosage diseases. Embo Molecular Medicine 16, pp. 616 - 640 (2024)

Altas, B.; Rhee, H. J.; Ju, A.; Solis, H. C.; Karaca, S.; Winchenbach, J.; Kaplan-Arabaci, O.; Schwark, M.; Ambrozkiewicz, M.; Lee, C. et al.; Spieth, L.; Wieser, G. L.; Chaugule, V. K.; Majoul, I.; Hassan, M. A.; Goel, R.; Wojcik, S. M.; Koganezawa, N.; Hanamura, K.; Rotin, D.; Pichler, A.; Mitkovski, M.; de Hoz, L.; Poulopoulos, A.; Urlaub, H.; Jahn, O.; Saher, G.; Brose, N.; Rhee, J.; Kawabe, H.: Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity. Journal of Cell Biology 223 (1), e201902050 (2024)