Publications

Sidorov, I.; Ogrinc, N.; Spieth, L.; Kopcil, M.; Heijink, M.; Dalebout, H.; Saher, G.; Berghoff, S. A.; Siuzdak, G.; Giera, M.: In-Source Fragmentation Annotation in Sterol Mass Spectrometry Imaging. Analytical Chemistry (2025)

Feng, R.; Spieth, L.; Liu, L.; Berghoff, S.; Franz, J.; Liu, Q.; Wang, Z.; Tiwari, V.; Vitale, S.; Frerich, S. et al.; Florensa, S.; Junker, N.; Huber, L.; Keller, M.; Müller, C.; Bracher, F.; Ge, X.; Rensen, P. C.N.; Kooij, G.; Hosang, L.; Chornyi, S.; Dichgans, M.; Gokce, O.; Saher, G.; Stadelmann, C.; Giera, M.; Groh, J.; Simons, M.: Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions. Immunity 58 (12), pp. 2989 - 3005.e10 (2025)

Triñanes-Ramos, J.; Bugiani, M.; van Rooijen-van Leeuwen, G. M.; Chevalier, J. A.; Siu, Y. J.; van Utenhove, E. L. H.; Hoogterp, L.; Witkamp, D.; Oudejans, E.; Lodder, B. et al.; Kole, M. H. P.; Saher, G.; Nave, K.-A.; Abbink, T. E. M.; van der Knaap, M. S.: Cell-specific Eif2b5 mutant mice: novel insights into roles of macroglia in vanishing white matter. Brain 148 (11), pp. 4112 - 4126 (2025)

Duque, M.; Chen, A. B.; Hsu, E.; Narayan, S.; Rymbek, A.; Begum, S.; Saher, G.; Cohen, A. E.; Olson, D. E.; Li, Y. et al.; Prober, D. A.; Bergles, D. E.; Fishman, M. C.; Engert, F.; Ahrens, M. B.: Ketamine induces plasticity in a norepinephrine-astroglial circuit to promote behavioral perseverance. Neuron 113 (3), pp. 426 - 443.e5 (2025)

Kaji, S.; Berghoff, S. A.; Spieth, L.; Schlaphoff, L.; Sasmita, A. O.; Vitale, S.; Büschgens, L.; Kedia, S.; Zirngibl, M.; Nazarenko, T. et al.; Damkou, A.; Hosang, L.; Depp, C.; Kamp, F.; Scholz, P.; Ewers, D.; Giera, M.; Ischebeck, T.; Wurst, W.; Wefers, B.; Schifferer, M.; Willem, M.; Nave, K.-A.; Haass, C.; Arzberger, T.; Jäkel, S.; Wirths, O.; Saher, G.; Simons, M.: Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis. Immunity 57 (11), pp. 2651 - 2668.e12 (2024)

da Silva Correia, A.; Schmitz, M.; Fischer, A.; da Silva Correia, S.; Simonetti, F. L.; Saher, G.; Goya‐Maldonado, R.; Arora, A. S.; Fischer, A.; Outeiro, T. F. et al.; Zerr, I.: Cellular prion protein acts as mediator of amyloid beta uptake by caveolin‐1 causing cellular dysfunctions in vitro and in vivo. Alzheimer's & Dementia 20 (10), pp. 6776 - 6792 (2024)

Sasmita, A. O.; Depp, C.; Nazarenko, T.; Sun, T.; Siems, S. B.; Ong, E. C.; Nkeh, Y. B.; Böhler, C.; Yu, X.; Bues, B. et al.; Evangelista, L.; Mao, S.; Morgado, B.; Wu, Z.; Ruhwedel, T.; Subramanian, S.; Börensen, F.; Overhoff, K.; Spieth, L.; Berghoff, S. A.; Sadleir, K. R.; Vassar, R.; Eggert, S.; Goebbels, S.; Saito, T.; Saido, T.; Saher, G.; Möbius, W.; Castelo-Branco, G.; Klafki, H.-W.; Wirths, O.; Wiltfang, J.; Jäkel, S.; Yan, R.; Nave, K.-A.: Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice. Nature Neuroscience 27, pp. 1668 - 1674 (2024)

Nkeh, Y. B.; Elgin, R. G.; Saher, G.: From the unknown to spotlight: newly identified hormone adjusts hepatic cholesterol synthesis to dietary uptake. Signal Transduction and Targeted Therapy 9, 165 (2024)

Späte, E.; Zhou, B.; Sun, T.; Kusch, K.; Asadollahi, E.; Siems, S. B.; Depp, C.; Werner, H. B.; Saher, G.; Hirrlinger, J. et al.; Möbius, W.; Nave, K.-A.; Göbbels, S.: Downregulated expression of lactate dehydrogenase in adult oligodendrocytes and its implication for the transfer of glycolysis products to axons. Glia 72 (8), pp. 1374 - 1391 (2024)

Krauter, D.; Stausberg, D.; Hartmann, T. J.; Volkmann, S.; Kungl, T.; Rasche, D. A.; Saher, G.; Fledrich, R.; Stassart, R.M.; Nave, K.-A. et al.; Göbbels, S.; Ewers, D.; Sereda, M. W.: Targeting PI3K/Akt/mTOR signaling in rodent models of PMP22 gene-dosage diseases. Embo Molecular Medicine 16, pp. 616 - 640 (2024)

Altas, B.; Rhee, H. J.; Ju, A.; Solis, H. C.; Karaca, S.; Winchenbach, J.; Kaplan-Arabaci, O.; Schwark, M.; Ambrozkiewicz, M.; Lee, C. et al.; Spieth, L.; Wieser, G. L.; Chaugule, V. K.; Majoul, I.; Hassan, M. A.; Goel, R.; Wojcik, S. M.; Koganezawa, N.; Hanamura, K.; Rotin, D.; Pichler, A.; Mitkovski, M.; de Hoz, L.; Poulopoulos, A.; Urlaub, H.; Jahn, O.; Saher, G.; Brose, N.; Rhee, J.; Kawabe, H.: Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity. Journal of Cell Biology 223 (1), e201902050 (2024)

Saher, G.: Cholesterol Metabolism in Aging and Age-Related Disorders. Annual Review of Neuroscience 46, pp. 59 - 78 (2023)

Schäffner, E.; Bosch-Queralt, M.; Edgar, J. M.; Lehning, M.; Strauß, J.; Fleischer, N.; Kungl, T.; Wieghofer, P.; Berghoff, S. A.; Reinert, T. et al.; Krueger, M.; Morawski, M.; Möbius, W.; Barrantes-Freer, A.; Stieler, J.; Sun, T.; Saher, G.; Schwab, M. H.; Wrede, C.; Frosch, M.; Prinz, M.; Reich, D. S.; Flügel, A.; Stadelmann, C.; Fledrich, R.; Nave, K.-A.; Stassart, R. M.: Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease. Nature Neuroscience 26, pp. 1218 - 1228 (2023)

Depp, C.; Sun, T.; Sasmita, A. O.; Spieth, L.; Berghoff, S. A.; Nazarenko, T.; Overhoff, K.; Steixner-Kumar, A. A.; Subramanian, S.; Arinrad, S. et al.; Ruhwedel, T.; Möbius, W.; Göbbels, S.; Saher, G.; Werner, H. B.; Damkou, A.; Zampar, S.; Wirths, O.; Thalmann, M.; Simons, M.; Saito, T.; Saido, T.; Krueger-Burg, D.; Kawaguchi, R.; Willem, M.; Haass, C.; Geschwind, D.; Ehrenreich, H.; Stassart, R. M.; Nave, K.-A.: Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease. Nature 618, pp. 349 - 357 (2023)

Lutomska, L. M.; Miok, V.; Krahmer, N.; García, I. G.; Gruber, T.; Le Thuc, O.; Murat, C. D.; Legutko, B.; Sterr, M.; Saher, G. et al.; Lickert, H.; Müller, T. D.; Ussar, S.; Tschöp, M. H.; Lutter, D.; García-Cáceres, C.: Diet triggers specific responses of hypothalamic astrocytes in time and region dependent manner. Glia 70 (11), pp. 2062 - 2078 (2022)

Düking, T.; Spieth, L.; Berghoff, S. A.; Piepkorn, L.; Schmidke, A. M.; Mitkovski, M.; Kannaiyan, N.; Hosang, L.; Scholz, P.; Shaib, A. H. et al.; Schneider, L. V.; Hesse, D.; Ruhwedel, T.; Sun, T.; Linhoff, L.; Trevisiol, A.; Köhler, S.; Pastor, A. M.; Misgeld, T.; Sereda, M.; Hassouna, I.; Rossner, M. J.; Odoardi, F.; Ischebeck, T.; de Hoz, L.; Hirrlinger, J.; Jahn, O.; Saher, G.: Ketogenic diet uncovers differential metabolic plasticity of brain cells. Science Advances 8 (37), eabo7639 (2022)

Berghoff, S. A.; Spieth, L.; Saher, G.: Local cholesterol metabolism orchestrates remyelination. Trends in Neurosciences 45 (4), pp. 272 - 283 (2022)

Berghoff, S. A.; Spieth, L.; Sun, T.; Hosang, L.; Depp, C.; Sasmita, A. O.; Vasileva, M. H.; Scholz, P.; Zhao, Y.; Krüger, D. et al.; Wichert, S.; Brown, E. R.; Michail, K.; Nave, K.-A.; Bonn, S.; Odoardi, F.; Rossner, M.; Ischebeck, T.; Edgar, J. M.; Saher, G.: Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice. Cell Reports 37 (4), 109889 (2021)

Spieth, L.; Berghoff, S. A.; Stumpf, S. K.; Winchenbach, J.; Michaelis, T.; Watanabe, T.; Gerndt, N.; Düking, T.; Hofer, S.; Ruhwedel, T. et al.; Shaib, A. H.; Willig, K. I.; Kronenberg, K.; Karst, U.; Frahm, J.; Rhee, J. S.; Minguet, S.; Möbius, W.; Kruse, N.; von der Brelie, C.; Michels, P.; Stadelmann, C.; Hülper, P.; Saher, G.: Anesthesia triggers drug delivery to experimental glioma in mice by hijacking caveolar transport. Neuro-Oncology Advances 3 (1), vdab140 (2021)

Berghoff, S. A.; Spieth, L.; Sun, T.; Hosang, L.; Schlaphoff, L.; Depp, C.; Düking, T.; Winchenbach, J.; Neuber, J.; Ewers, D. et al.; Scholz, P.; van der Meer, F.; Cantuti-Castelvetri, L.; Sasmita, A. O.; Meschkat, M.; Ruhwedel, T.; Möbius, W.; Sankowski, R.; Prinz, M.; Huitinga, I.; Sereda, M. W.; Odoardi, F.; Ischebeck, T.; Simons, M.; Stadelmann-Nessler, C.; Edgar, J. M.; Nave, K.-A.; Saher, G.: Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis. Nature Neuroscience 24, pp. 47 - 60 (2021)