Publications of Patrick Cramer

Kabinger, F.; Doze, V.; Schmitzová, J.; Lidschreiber, M.; Dienemann, C.; Cramer, P.: Structural basis of SARS-CoV-2 polymerase inhibition by nonnucleoside inhibitor HeE1-2Tyr. Proceedings of the National Academy of Sciences of the United States of America 122 (10), e2419854122 (2025)

Lysakovskaia, K.; Devadas, A.; Schwalb, B.; Lidschreiber, M.; Cramer, P.: Promoter-proximal RNA polymerase II termination regulates transcription during human cell type transition. Nature Structural & Molecular Biology (2025)

Rengachari, S.; Hainthaler, T.; Oberthür, C.; Lidschreiber, M.; Cramer, P.: Mechanism of polyadenylation-independent RNA polymerase II termination. Nature Structural & Molecular Biology 32, pp. 339 - 345 (2025)

van den Heuvel, D.; Rodríguez-Martínez, M.; van der Meer, P. J.; Nieto Moreno, N.; Park, J.; Kim, H.-S.; van Schie, J. J.M.; Wondergem, A. P.; D’Souza, A.; Yakoub, G. et al.; Herlihy, A. E.; Kashyap, K.; Boissière, T.; Walker, J.; Mitter, R.; Apelt, K.; de Lint, K.; Kirdök, I.; Ljungman, M.; Wolthuis, R. M.F.; Cramer, P.; Schärer, O. D.; Kokic, G.; Svejstrup, J. Q.; Luijsterburg, M. S.: STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair. Cell 187 (25), pp. 7107 - 7125.e25 (2024)

Engeholm, M.; Roske, J. J.; Oberbeckmann, E.; Dienemann, C.; Lidschreiber, M.; Cramer, P.; Farnung, L.: Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT. Molecular Cell 84 (18), pp. 3423 - 3437.e8 (2024)

Patil, S.; Cremosnik, G.; Dötsch, L.; Flegel, J.; Schulte, B.; Maier, K. C.; Žumer, K.; Cramer, P.; Janning, P.; Sievers, S. et al.; Ziegler, S.; Waldmann, H.: The Pseudo-Natural Product Tafbromin Selectively Targets the TAF1 Bromodomain 2. Angewandte Chemie International Edition 63 (32), e202404645 (2024)

Velychko, T.; Mohammad, E.; Ferrer-Vicens, I.; Parfentev, I.; Werner, M.; Studniarek, C.; Schwalb, B.; Urlaub, H.; Murphy, S.; Cramer, P. et al.; Lidschreiber, M.: CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release. Molecular Cell 84 (12), pp. 2287 - 2303.e10 (2024)

Žumer, K.; Ochmann, M.; Aljahani, A.; Zheenbekova, A.; Devadas, A.; Maier, K. C.; Rus, P.; Neef, U.; Oudelaar, A. M.; Cramer, P.: FACT maintains chromatin architecture and thereby stimulates RNA polymerase II pausing during transcription in vivo. Molecular Cell 84 (11), pp. 2053 - 2069.e9 (2024)

Fianu, I.; Ochmann, M.; Walshe, J. L.; Dybkov, O.; Cruz, J. N.; Urlaub, H.; Cramer, P.: Structural basis of Integrator-dependent RNA polymerase II termination. Nature 629, pp. 219 - 227 (2024)

Zhan, Y.; Grabbe, F.; Oberbeckmann, E.; Dienemann, C.; Cramer, P.: Three-step mechanism of promoter escape by RNA polymerase II. Molecular Cell 84 (9), pp. 1699 - 1710.e6 (2024)

Cramer, P.: Good reasons for structural biology. Nature Structural & Molecular Biology 31, pp. 393 - 394 (2024)

Kokic, G.; Yakoub, G.; van den Heuvel, D.; Wondergem, A. P.; van der Meer, P. J.; van der Weegen, Y.; Chernev, A.; Fianu, I.; Fokkens, T. J.; Lorenz, S. et al.; Urlaub, H.; Cramer, P.; Luijsterburg, M. S.: Structural basis for RNA polymerase II ubiquitylation and inactivation in transcription-coupled repair. Nature Structural & Molecular Biology 31, pp. 536 - 547 (2024)

Oberbeckmann, E.; Quililan, K.; Cramer, P.; Oudelaar, A. M.: In vitro reconstitution of chromatin domains shows a role for nucleosome positioning in 3D genome organization. Nature Genetics 56, pp. 483 - 492 (2024)

Chen, Y.; Cramer, P.: RNA polymerase II elongation factors use conserved regulatory mechanisms. Current Opinion in Structural Biology 84, 102766 (2024)

Sun, Y.; Wiese, M.; Hmadi, R.; Karayol, R.; Seyfferth, J.; Martinez Greene, J.A.; Erdogdu, N.U.; Deboutte, W.; Arrigoni, L.; Holz, H. et al.; Renschler, G.; Hirsch, N.; Foertsch, A.; Basilicata, M.F.; Stehle, T.; Shvedunova, M.; Bella, C.; Pessoa Rodrigues, C.; Schwalb, B.; Cramer, P.; Manke, T.; Akhtar, A.: MSL2 ensures biallelic gene expression in mammals. Nature 624 (7990), pp. 173 - 181 (2023)

Chen, Y.; Kokic, G.; Dienemann, C.; Dybkov, O.; Urlaub, H.; Cramer, P.: Structure of the transcribing RNA polymerase II–Elongin complex. Nature Structural & Molecular Biology 30, pp. 1925 - 1935 (2023)

Palau, A.; Segerberg, F.; Lidschreiber, M.; Lidschreiber, K.; Naughton, A.J.; Needhamsen, M.; Jung, L.A.; Jagodic, M.; Cramer, P.; Lehmann, S. et al.; Carlsten, M.; Lennartsson, A.: Perturbed epigenetic transcriptional regulation in AML with IDH mutations causes increased susceptibility to NK cells. Leukemia 37, pp. 1830 - 1841 (2023)

Garg, G.; Dienemann, C.; Farnung, L.; Schwarz, J.; Linden, A.; Urlaub, H.; Cramer, P.: Structural insights into human co-transcriptional capping. Molecular Cell 83 (14), pp. 2464 - 2477.e5 (2023)

Rouvière, J. O.; Salerno-Kochan, A.; Lykke-Andersen, S.; Garland, W.; Dou, Y.; Rathore, O.; Molska, E. Š.; Wu, G.; Schmid, M.; Bugai, A. et al.; Jakobsen, L.; Zumer, K.; Cramer, P.; Andersen, J. S.; Conti, E.; Jensen, T. H.: ARS2 instructs early transcription termination-coupled RNA decay by recruiting ZC3H4 to nascent transcripts. Molecular Cell 83 (13), pp. 2240 - 2257 (2023)

Abril-Garrido, J.; Dienemann, C.; Grabbe, F.; Velychko, T.; Lidschreiber, M.; Wang, H.; Cramer, P.: Structural basis of transcription reduction by a promoter-proximal +1 nucleosome. Molecular Cell 83 (11), pp. 1798 - 1809.e7 (2023)