Publications of H. Stark

Rodnina, M. V.; Fischer, N.; Maracci, C.; Stark, H.: Ribosome dynamics during decoding. Philosophical Transactions of the Royal Society B 372 (1716), 20160182 (2017)

Bertram, K.; Agafonov, D. E.; Liu, W.; Dybkov, O.; Will, C. L.; Hartmuth, K.; Urlaub, H.; Kastner, B.; Stark, H.; Lührmann, R.: Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature 542 (7641), pp. 318 - 323 (2017)

Fischer, N.; Neumann, P.; Bock, l. V.; Maracci, C.; Wang, Z.; Paleskava, A.; Konevega, A. L.; Schröder, G. F.; Grubmüller, H.; Ficner, R. et al.; Rodnina, M. V.; Stark, H.: The pathway to GTPase activation of elongation factor SelB on the ribosome. Nature 540 (7631), pp. 80 - 85 (2016)

Rauhut, R.; Fabrizio, P.; Dybkov, O.; Hartmuth, K.; Pena, V.; Chari, A.; Kumar, V.; Lee, C. T.; Urlaub, H.; Kastner, B. et al.; Stark, H.; Lührmann, R.: Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Science 353 (6306), pp. 1399 - 1405 (2016)

Paknia, E.; Chari, A.; Stark, H.; Fischer, U.: The ribosome cooperates with the assembly chaperone pICln to initiate formation of snRNPs. Cell Reports 16 (12), pp. 3103 - 3112 (2016)

Hons, M.; Huis in ‘t Veld, P. J.; Kaesler, J.; Rombaut, P.; Schleiffer, A.; Herzog, F.; Stark, H.; Peters, J. M.: Topology and structure of an engineered human cohesin complex bound to Pds5B. Nature Communications 7, 12523 (2016)

Yamaguchi, M.; VanderLinden, R.; Weissmann, F.; Qiao, R.; Dube, P.; Brown, N. G.; Haselbach, D.; Zhang, W.; Sidhu, S. S.; Peters, J. M. et al.; Stark, H.; Schulman, B. A.: Cryo-EM of mitotic checkpoint complex-bound APC/C reveals reciprocal and conformational regulation of ubiquitin ligation. Molecular Cell 63 (4), pp. 593 - 607 (2016)

Schrader, J.; Henneberg, F.; Mata, R. A.; Tittmann, K.; Schneider, T. R.; Stark, H.; Bourenkov, G.; Chari, A.: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science 353 (6299), pp. 594 - 598 (2016)

Brown, N. G.; VanderLinden, R.; Watson, E. R.; Weissmann, F.; Ordureau, A.; Wu, K. P.; Zhang, W.; Yu, S.; Mercredi, P. Y.; Harrison, J. S. et al.; Davidson, I. F.; Qiao, R. P.; Lu, Y.; Dube, P.; Brunner, M. R.; Grace, C. R. R.; Miller, D. J.; Haselbach, D.; Jarvis, M. A.; Yamaguchi, M.; Yanishevski, D.; Petzold, G.; Sidhu, S. S.; Kuhlman, B.; Kirschner, M. W.; Harper, J. W.; Peters, J. M.; Stark, H.; Schulman, B. A.: Dual RING E3 architectures regulate multiubiquitination and ubiquitin chain elongation by APC/C. Cell 165 (6), pp. 1440 - 1453 (2016)

Qiao, R. P.; Weissmann, F.; Yamaguchi, M.; Brown, N. G.; VanderLinden, R.; Imre, R.; Jarvis, M. A.; Brunner, M. R.; Davidson, I. F.; Litos, G. et al.; Haselbach, D.; Mechtler, K.; Stark, H.; Schulman, B. A.; Peters, J. M.: Mechanism of APC/C-CDC20 activation by mitotic phosphorylation. Proceedings of the National Academy of Sciences of the United States of America 113 (19), pp. E2570 - E2578 (2016)

Weissmann, F.; Petzold, G.; VanderLinden, R.; in'T Veld, P. J. H.; Brown, N. G.; Lampert, F.; Westermann, S.; Stark, H.; Schulman, B. A.; Peters, J. M.: biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes. Proceedings of the National Academy of Sciences of the United States of America 113 (19), pp. E2564 - E2569 (2016)

Agafonov, D. E.; Kastner, B.; Dybkov, O.; Hofele, R. V.; Liu, W.; Urlaub, H.; Lührmann, R.; Stark, H.: Molecular architecture of the human U4/U6.U5 tri-snRNP. Science 351 (6280), pp. 1416 - 1420 (2016)

Stark, H.; Chari, A.: Sample preparation of biological macromolecular assemblies for the determination of high-resolution structures by cryo-electron microscopy. Microscopy 65 (1), pp. 23 - 34 (2016)

Pleiner, T.; Bates, M.; Trakhanov, S.; Lee, C. T.; Schliep, J. E.; Chug, H.; Böhning, M.; Stark, H.; Urlaub, H.; Görlich, D.: Nanobodies: Site-specific labeling for super-resolution imaging, rapid epitope-mapping and native protein complex isolation. eLife 4, e11349 (2015)

Chari, A.; Haselbach, D.; Kirves, J. M.; Ohmer, J.; Paknia, E.; Fischer, N.; Ganichkin, O.; Moller, V.; Frye, J. J.; Petzold, G. et al.; Jarvis, M.; Tietzel, M.; Grimm, C.; Peters, J. M.; Schulman, B. A.; Tittmann, K.; Markl, J.; Fischer, U.; Stark, H.: ProteoPlex: Stability optimization of macromolecular complexes by sparse-matrix screening of chemical space. Nature Methods 12 (9), pp. 859 - 865 (2015)

Hauer, F.; Gerle, C.; Fischer, N.; Oshima, A.; Shinzawa-Itoh, K.; Shimada, S.; Yokoyama, K.; Fujiyoshi, Y.; Stark, H.: GraDeR: Membrane protein complex preparation for single-particle cryo-EM. Structure 23 (9), pp. 1769 - 1775 (2015)

Lin , Y. J.; Liu, W.; Stark, H.; Huang, C. T.: Expression of enterovirus 71 virus-like particles in transgenic enoki (Flammulina velutipes). Applied Microbiology and Biotechnology 99 (16), pp. 6765 - 6774 (2015)

Martinez-Rucobo, F. W.; Kohler, R.; Waterbeemd, M. v. d.; Heck, A. J.; Hemann, M.; Herzog, F.; Stark, H.; Cramer, P.: Molecular basis of transcription-coupled pre-mRNA capping. Molecular Cell 58 (6), pp. 1079 - 1089 (2015)

Brown, N. G.; VanderLinden, R.; Watson, E. R.; Qiao, R. P.; Grace, C. R. R.; Yamaguchi, M.; Weissmann, F.; Frye, J. J.; Dube, P.; Cho, S. E. et al.; Actis, M. L.; Rodrigues, P.; Fujii, N.; Peters, J. M.; Stark, H.; Schulman, B. A.: RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex. Proceedings of the National Academy of Sciences of the United States of America 112 (17), pp. 5272 - 5279 (2015)

Fischer, N.; Neumann, P.; Konevega, A. L.; Bock, L. V.; Ficner, R.; Rodnina, M. V.; Stark, H.: Structure of the E. coli ribosome–EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM. Nature 520 (7548), pp. 567 - 570 (2015)