Publications of R. Lührmann

Tauchert, M. J.; Fourmann, J. B.; Christian, H.; Lührmann, R.; Ficner, R.: Structural and functional analysis of the RNA helicase Prp43 from the thermophilic eukaryote Chaetomium thermophilum. Acta Crystallographica Section F 72 (2), pp. 112 - 120 (2016)

Jagtap, P. K. A.; Garg, D.; Kapp, T. G.; Will, C. L.; Demme, O.; Lührmann, R.; Kessler, H.; Sattler, M.: Rational design of cyclic peptide inhibitors of U2AF homology motif (UHM) domains to modulate pre-mRNA splicing. Journal of Medicinal Chemistry 59 (22), pp. 10190 - 10197 (2016)

Absmeier, E.; Wollenhaupt, J.; Mozaffari-Jovin, S.; Becke, C.; Lee, C. T.; Preussner, M.; Heyd, F.; Urlaub, H.; Lührmann, R.; Santos, K. F. et al.; Wahl, M. C.: The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation. Genes and Development 29 (24), pp. 2576 - 2587 (2015)

Rigo, N.; Sun, C.; Fabrizio, P.; Kastner, B.; Lührmann, R.: Protein localisation by electron microscopy reveals the architecture of the yeast spliceosomal B complex. EMBO Journal 34 (24), pp. 3059 - 3073 (2015)

Schneider, C.; Agafonov, D. E.; Schmitzova, J.; Hartmuth, K.; Fabrizio, P.; Lührmann, R.: Dynamic contacts of U2, RES, Cwc25, Prp8 and Prp45 proteins with the Pre-mRNA branch-site and 3' splice site during catalytic activation and step 1 catalysis in yeast spliceosomes. PLoS Genetics 11 (9), e1005539 (2015)

Boesler, C.; Rigo, N.; Agafonov, D. E.; Kastner, B.; Urlaub, H.; Will, C. L.; Lührmann, R.: Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5‘ splice site. RNA 21 (11), pp. 1993 - 2005 (2015)

Benito, E.; Urbanke, H.; Ramachandran, B.; Barth, J.; Halder, R.; Awasthi, A.; Jain, G.; Capece, J. G.; Burkhardt, S.; Navarro-Sala, M. et al.; Nagarajan, S.; Schütz, A. L.; Johnsen, S. A.; Bonn, S.; Lührmann, R.; Dean, C.; Fischer, A.: HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models. Journal of Clinical Investigation 125 (9), pp. 3572 - 3584 (2015)

Wahl, M. C.; Lührmann, R.: Snapshot: Spliceosome dynamics III. Cell 162 (3), pp. 690 - 690.e1 (2015)

Wahl, M. C.; Lührmann, R.: SnapShot: Spliceosome dynamics II. Cell 162 (2), pp. 456 - 456.e1 (2015)

Liu, S.; Mozaffari-Jovin, S.; Wollenhaupt, J.; Santos, , K. F.; Theuser, M.; Dunin-Horkawicz, S.; Fabrizio, P.; Bujnicki, J. M.; Lührmann, R.; Wahl, M. C.: A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing. eLife 4, e07320 (2015)

Wahl, M. C.; Lührmann, R.: SnapShot: Spliceosome dynamics I. Cell 161 (6), pp. 1474 - 1474.e1 (2015)

De, I.; Bessonov, S.; Hofele, R.; Dos Santos, K.; Will, C. L.; Urlaub, H.; Lührmann, R.; Pena, V.: The RNA helicase ​Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes. Nature Structural and Molecular Biology 22 (2), pp. 138 - 144 (2015)

Warkocki, Z.; Schneider, C.; Mozaffari-Jovin, S.; Schmitzova, J.; Höbartner, C.; Fabrizio, P.; Lührmann, R.: The G-patch protein Spp2 couples the spliceosome-stimulated ATPase activity of the DEAH-box protein Prp2 to catalytic activation of the spliceosome. Genes and Development 29 (1), pp. 94 - 107 (2015)

Pawellek, A.; McElroy, S.; Samatov, T.; Mitchell, L.; Woodland, A.; Ryder, U.; Gray, D.; Lührmann, R.; Lamond, A.: Identification of small molecule inhibitors of pre-mRNA splicing. The Journal of Biological Chemistry 289 (50), pp. 34683 - 34698 (2014)

Alló, M.; Agirre, E.; Bessonov, S.; Bertucci, P.; Acuña, L. G.; Buggiano, V.; Bellora, N.; Singh, B.; Petrilloa, E.; Blaustein, M. et al.; Miñana, B.; Dujardin, G.; Pozzi, B.; Pelisch, F.; Bechara, E.; Agafonov, D. E.; Srebrow, A.; Lührmann, R.; Valcárcel, J.; Eyras, E.; Kornblihtt, A. R.: Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells. Proceedings of the National Academy of Sciences of the United States of America 111 (44), pp. 15622 - 15629 (2014)

Wysoczanski, P.; Schneider, C.; Xiang, S. Q.; Munari, F.; Trowitzsch, S.; Wahl, M. C.; Lührmann, R.; Becker, S.; Zweckstetter, M.: Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex. Nature Structural and Molecular Biology 21 (10), pp. 911 - 918 (2014)

Möhlmann, S.; Mathew, R.; Neumann, P.; Schmitt, A.; Lührmann, R.; Ficner, R.: Structural and functional analysis of the human spliceosomal DEAD-box helicase Prp28. Acta Crystallographica D 70 (6), pp. 1622 - 1630 (2014)

Mozaffari-Jovin, S.; Wandersleben, T.; Santos, K. F.; Will, C. L.; Lührmann, R.; Wahl, M. C.: Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans. RNA Biology 11 (4), pp. 298 - 312 (2014)

Schmidt, C.; Groenborg, M.; Deckert, J.; Bessonov, S.; Conrad, T.; Lührmann, R.; Urlaub, H.: Mass spectrometry–based relative quantification of proteins in precatalytic and catalytically active spliceosomes by metabolic labeling (SILAC), chemical labeling (iTRAQ), and label-free spectral count. RNA 20 (3), pp. 406 - 420 (2014)

Xiang, S. Q.; Gapsys, V.; Kim, H. Y.; Bessonov, S.; Hsiao, H. H.; Möhlmann, S.; Klaukien, V.; Ficner, R.; Becker, S.; Urlaub, H. et al.; Lührmann, R.; de Groot, B.; Zweckstetter, M.: Phosphorylation drives a dynamic switch in serine/arginine-rich proteins. Structure 21 (12), pp. 2162 - 2174 (2013)