Publications of C. L. Will

Jagtap, P. K. A.; Garg, D.; Kapp, T. G.; Will, C. L.; Demme, O.; Lührmann, R.; Kessler, H.; Sattler, M.: Rational design of cyclic peptide inhibitors of U2AF homology motif (UHM) domains to modulate pre-mRNA splicing. Journal of Medicinal Chemistry 59 (22), pp. 10190 - 10197 (2016)

Boesler, C.; Rigo, N.; Agafonov, D. E.; Kastner, B.; Urlaub, H.; Will, C. L.; Lührmann, R.: Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5‘ splice site. RNA 21 (11), pp. 1993 - 2005 (2015)

De, I.; Bessonov, S.; Hofele, R.; Dos Santos, K.; Will, C. L.; Urlaub, H.; Lührmann, R.; Pena, V.: The RNA helicase ​Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes. Nature Structural and Molecular Biology 22 (2), pp. 138 - 144 (2015)

Mozaffari-Jovin, S.; Wandersleben, T.; Santos, K. F.; Will, C. L.; Lührmann, R.; Wahl, M. C.: Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans. RNA Biology 11 (4), pp. 298 - 312 (2014)

Hofmann, J. C.; Tegha-Dunghu, J.; Dräger, S.; Will, C. L.; Lührmann, R.; Gruss, O. J.: The Prp19 complex directly functions in mitotic spindle assembly. PLoS One 8 (9), e74851 (2013)

Mozaffari-Jovin, S.; Wandersleben, T.; Santos, K. F.; Will, C. L.; Lührmann, R.; Wahl, M. C.: Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8. Science 341 (6141), pp. 80 - 84 (2013)

Mozaffari-Jovin, S.; Santos, K. F.; Hsiao, H. H.; Will, C. L.; Urlaub, H.; Wahl, M. C.; Lührmann, R.: The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA. Genes and Development 26 (23), pp. 2422 - 2434 (2012)

Girard, C.; Will, C. L.; Peng, J.; Makarov, E. M.; Kastner, B.; Lemm, I.; Urlaub, H.; Hartmuth, K.; Lührmann, R.: Retention of posttranscriptional spliceosomes in nuclear speckles until splicing completion. Nature communications 3, 994 (2012)

Hegele, A.; Kamburov, A.; Grossmann, A.; Sourlis, C.; Wowro, S.; Weimann, M.; Will, C. L.; Pena, V.; Lührmann, R.; Stelzl, U.: Dynamic protein-protein interaction wiring of the human spliceosome. Molecular Cell 45 (4), pp. 567 - 580 (2012)

Agafonov, D. E.; Deckert, J.; Wolf, E.; Odenwälder, P.; Bessonov, S.; Will, C. L.; Urlaub, H.; Lührmann, R.: Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method. Molecular and Cellular Biology 31 (13), pp. 2667 - 2682 (2011)

Popow, J.; Englert, M.; Weitzer, S.; Schleiffer, A.; Mierzwa, B.; Mechtler, K.; Trowitzsch, S.; Will, C. L.; Lührmann, R.; Soell, D. et al.; Martinez, J.: HSPC117 is the essential subunit of a human tRNA splicing ligase complex. Science 331 (6018), pp. 760 - 764 (2011)

Bessonov, S.; Anokhina, M.; Krasauskas, A.; Golas, M. M.; Sander, B.; Will, C. L.; Urlaub, H.; Stark, H.; Lührmann, R.: Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis. RNA 16 (12), pp. 2384 - 2403 (2010)

Grote, M.; Wolf, E.; Will, C. L.; Lemm, I.; Agafonov, D. E.; Schomburg, A.; Fischle, W.; Urlaub, H.; Lührmann, R.: Molecular architecture of the human Prp19/CDC5L complex. Molecular and Cellular Biology 30 (9), pp. 2105 - 2119 (2010)

Schneider, M.; Will, C. L.; Anokhina, M.; Tazi, J.; Urlaub, H.; Lührmann, R.: Exon definition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexes. Molecular Cell 38 (2), pp. 223 - 235 (2010)

Verbeeren, J.; Niemelae, E. H.; Turunen, J. J.; Will, C. L.; Ravanti, J. J.; Lührmann, R.; Frilander, M. J.: An ancient mechanism for splicing control: U11 snRNP as an activator of alternative splicing. Molecular Cell 37 (6), pp. 821 - 833 (2010)

Schneider, M.; Hsiao, H. H.; Will, C. L.; Giet, R.; Urlaub, H.; Lührmann, R.: Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation. Nature Structural and Molecular Biology 17 (2), pp. 216 - 222 (2010)

Wahl, M. C.; Will, C. L.; Lührmann, R.: The spliceosome: design principles of a dynamic RNP machine. Cell 136 (4), pp. 701 - 718 (2009)

Herold, N.; Will, C. L.; Wolf, E.; Kastner, B.; Urlaub, H.; Lührmann, R.: Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Molecular and Cellular Biology 29 (1), pp. 281 - 301 (2009)

Pessa, H. K.; Will, C. L.; Meng, X.; Schneider, C.; Watkins, N. J.; Peraelae, N.; Nymark, M.; Turunen, J. J.; Luehrmann, R.; Frilander, M. J.: Minor spliceosome components are predominantly localized in the nucleus. Proceedings of the National Academy of Sciences of the United States of America 105, pp. 8655 - 8660 (2008)

Turunen, J. J.; Will, C. L.; Grote, M.; Luehrmann, R.; Frilander, M. J.: The U11-48K protein contacts the 5' splice site of U12-Type introns and the U11-59K protein. Molecular and Cellular Biology 28 (10), pp. 3548 - 3560 (2008)