Publikationen von Reinhard Lührmann
Alle Typen
Zeitschriftenartikel (192)
Zeitschriftenartikel
43, S. 1065 - 1088 (2024)
Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins. The EMBO Journal
Zeitschriftenartikel
9 (9), eadf178 (2023)
Regulation of 3′ splice site selection after step 1 of splicing by spliceosomal C* proteins. Science Advances
Zeitschriftenartikel
12 (3), e759 (2022)
Activation of autophagy reverses progressive and deleterious protein aggregation in PRPF31 patient‐induced pluripotent stem cell‐derived retinal pigment epithelium cells. Clinical and Translational Medicine
Zeitschriftenartikel
596 (7871), S. 296 - 300 (2021)
Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature
Zeitschriftenartikel
49 (10), S. 5845 - 5866 (2021)
SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes. Nucleic Acids Research
Zeitschriftenartikel
371 (6526), S. 305 - 309 (2021)
Structure of a transcribing RNA polymerase II–U1 snRNP complex. Science
Zeitschriftenartikel
370 (6523), eabc3753 (2020)
Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science
Zeitschriftenartikel
80 (1), S. 127 - 139.e6 (2020)
Structural insights into the roles of metazoan-specific splicing factors in the human step 1 spliceosome. Molecular Cell
Zeitschriftenartikel
583 (7815), S. 310 - 313 (2020)
Molecular architecture of the human 17S U2 snRNP. Nature
Zeitschriftenartikel
77 (6), S. 1322 - 1339.e11 (2020)
Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription. Molecular Cell
Zeitschriftenartikel
26 (2), S. vii - viii (2020)
Kiyoshi Nagai (1949-2019). RNA
Zeitschriftenartikel
11 (11), a032417 (2019)
Structural insights into nuclear pre-mRNA splicing in higher eukaryotes. Cold Spring Harbor Perspectives in Biology
Zeitschriftenartikel
105 (3), S. 573 - 587 (2019)
Pathogenic abnormal splicing due to intronic deletions that induce biophysical space constraint for spliceosome assembly. American Journal of Human Genetics
Zeitschriftenartikel
10 (1), 3639 (2019)
Smu1 and RED are required for activation of spliceosomal B complexes assembled on short introns. Nature Communications
Zeitschriftenartikel
46 (22), S. 12126 - 12138 (2018)
Multiple RNA-RNA tertiary interactions are dispensable for formation of a functional U2/U6 RNA catalytic core in the spliceosome. Nucleic Acids Research
Zeitschriftenartikel
9, 4234 (2018)
Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa. Nature Communications
Zeitschriftenartikel
46 (7), S. 3774 - 3790 (2018)
The Sm-core mediates the retention of partially-assembled spliceosomal snRNPs in Cajal bodies until their full maturation. Nucleic Acids Research
Zeitschriftenartikel
70 (2), S. 265 - 273 (2018)
Structural basis of splicing modulation by antitumor macrolide compounds. Molecular Cell
Zeitschriftenartikel
69 (6), S. 979 - 992 (2018)
Prp19/Pso4 is an autoinhibited ubiquitin ligase activated by stepwise assembly of three splicing factors. Molecular Cell
Zeitschriftenartikel
172 (3), S. 454 - 464, e1-e5 (2018)
Structure and conformational dynamics of the human spliceosomal Bact complex. Cell