Publications of R. Lührmann

Sander, B.; Golas, M. M.; Lührmann, R.; Stark, H.: An approach for de novo structure determination of dynamic molecular assemblies by electron cryomicroscopy. Structure 18 (6), pp. 667 - 676 (2010)

Grote, M.; Wolf, E.; Will, C. L.; Lemm, I.; Agafonov, D. E.; Schomburg, A.; Fischle, W.; Urlaub, H.; Lührmann, R.: Molecular architecture of the human Prp19/CDC5L complex. Molecular and Cellular Biology 30 (9), pp. 2105 - 2119 (2010)

Schneider, M.; Will, C. L.; Anokhina, M.; Tazi, J.; Urlaub, H.; Lührmann, R.: Exon definition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexes. Molecular Cell 38 (2), pp. 223 - 235 (2010)

Stegmann, C.; Lührmann, R.; Wahl, M. C.: The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein. PLoS ONE 5, e10013 (2010)

Strzelecka, M.; Trowitzsch, S.; Weber, G.; Lührmann, R.; Oates, A. C.; Neugebauer, K. M.: Coilin-dependent snRNP assembly is essential for zebrafish embryogenesis. Nature Structural and Molecular Biology 17 (4), pp. 403 - 409 (2010)

Verbeeren, J.; Niemelae, E. H.; Turunen, J. J.; Will, C. L.; Ravanti, J. J.; Lührmann, R.; Frilander, M. J.: An ancient mechanism for splicing control: U11 snRNP as an activator of alternative splicing. Molecular Cell 37 (6), pp. 821 - 833 (2010)

Schneider, M.; Hsiao, H. H.; Will, C. L.; Giet, R.; Urlaub, H.; Lührmann, R.: Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation. Nature Structural and Molecular Biology 17 (2), pp. 216 - 222 (2010)

Dhir, A.; Buratti, E.; van Santen, M. A.; Lührmann, R.; Baralle, F. E.: The intronic splicing code: Multiple factors involved in ATM pseudoexon definition. The EMBO Journal 29, pp. 749 - 760 (2010)

Schmidt, C.; Lenz, C.; Grote, M.; Lührmann, R.; Urlaub, H.: Determination of protein stoichiometry within protein complexes using absolute quantification and multiple reaction monitoring. Analytical Chemistry 82 (7), pp. 2784 - 2796 (2010)

Weber, G.; Trowitzsch, S.; Kastner, B.; Lührmann, R.; Wahl, M. C.: Functional organization of the Sm core in the crystal structure of human U1 snRNP. EMBO Journal 29, pp. 4172 - 4184 (2010)

Warkocki, Z.; Odenwälder, P.; Schmitzova, J.; Platzmann, F.; Stark, H.; Urlaub, H.; Ficner, R.; Fabrizio, P.; Lührmann, R.: Reconstitution of both steps of S. cerevisiae splicing with purified spliceosomal components. Nature Structural and Molecular Biology 16 (12), pp. 1237 - 1243 (2009)

Wolf, E.; Kastner, B.; Deckert, J.; Merz, C.; Stark, H.; Lührmann, R.: Exon, intron and splice site locations in the spliceosomal B complex. EMBO Journal 28, pp. 2283 - 2292 (2009)

Wahl, M. C.; Will, C. L.; Lührmann, R.: The spliceosome: design principles of a dynamic RNP machine. Cell 136 (4), pp. 701 - 718 (2009)

Fabrizio, P.; Dannenberg, J.; Dube, P.; Kastner, B.; Stark, H.; Urlaub, H.; Lührmann, R.: The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome. Molecular Cell 36 (4), pp. 593 - 608 (2009)

Trowitzsch, S.; Weber, G.; Lührmann, R.; Wahl, M. C.: Crystal structure of the Pml1p subunit of the yeast precursor mRNA retention and splicing complex. Journal of Molecular Biology 385 (2), pp. 531 - 541 (2009)

Herold, N.; Will, C. L.; Wolf, E.; Kastner, B.; Urlaub, H.; Lührmann, R.: Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Molecular and Cellular Biology 29 (1), pp. 281 - 301 (2009)

Kofler, M.; Schuemann, M.; Merz, C.; Kosslick, D.; Schlundt, A.; Tannert, A.; Schaefer, M.; Lührmann, R.; Krause, E.; Freund, C.: Proline-rich sequence recognition I: Marking GYF and WW domain assembly sites in early spliceosomal complexes. Molecular and Cellular Proteomics 8, pp. 2461 - 2473 (2009)

Kuhn, A. N.; van Santen, M. A.; Schwienhorst, A.; Urlaub, H.; Lührmann, R.: Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation. RNA 15 (1), pp. 153 - 175 (2009)

Lührmann, R.; Stark, H.: Structural mapping of spliceosomes by electron microscopy. Current Opinion in Structural Biology 19, pp. 96 - 102 (2009)

Pena, V.; Jovin, S. M.; Fabrizio, P.; Orlowski, J.; Bujnicki, J. M.; Lührmann, R.; Wahl, M. C.: Common design principles in the spliceosomal RNA helicase Brr2 and in the Hel308 DNA helicase. Molecular Cell 35 (4), pp. 454 - 466 (2009)