Scientific Seminar: Immunotherapeutical treatment of myocardial inflammation

Myocarditis is an inflammatory heart disease that leads to loss of cardiomyocytes and frequently precipitates fibrotic remodeling of the myocardium culminating in heart failure. However, the molecular mechanisms underlying immune cell control and maintenance of tissue integrity in the inflamed cardiac microenvironment remain elusive. In this seminar, I will present our recent studies based on single cell transcriptomics analyses of inflamed murine and human myocardial tissues. Our results indicate the BMP4-Gremlin axis as a drugable pathway for the treatment of myocardial inflammation.