Publications

Vrentzou, A.; Leidner, F.; Schmidt, C. C.; Grubmüller, H.; Stein, A.: UBE2J2 sensitizes the ERAD ubiquitination cascade to changes in membrane lipid saturation. Nature Communications 16, 8973 (2025)

Swarnkar, A.; Leidner, F.; Rout, A. K.; Ainatzi, S.; Schmidt, C. C.; Becker, S.; Urlaub, H.; Griesinger, C.; Grubmüller, H.; Stein, A.: Determinants of chemoselectivity in ubiquitination by the J2 family of ubiquitin-conjugating enzymes. The EMBO Journal 43 (24), pp. 6705 - 6739 (2024)

Schmidt, C. C.; Vasic, V.; Stein, A.: Doa10 is a membrane protein retrotranslocase in ER-associated protein degradation. eLife 9, e56945 (2020)

Natarajan, N.; Foresti, O.; Wendrich, K.; Stein, A.; Carvalho, P.: Quality control of protein complex assembly by a transmembrane recognition factor. Molecular Cell 77 (1), pp. 108 - 119 (2020)

Vasic, V.; Denkert, N.; Schmidt, C.; Riedel, D.; Stein, A.; Meinecke, M.: Hrd1 forms the retrotranslocation pore regulated by auto-ubiquitination and binding of misfolded proteins. Nature Cell Biology 22, pp. 274 - 281 (2020)

Guan, L.; Denkert, N.; Eisa, A.; Lehmann, M.; Sjuts, I.; Weiberg, A.; Soll, J.; Meinecke, M.; Schwenkert, S.: JASSY, a chloroplast outer membrane protein required for jasmonate biosynthesis. Proceedings of the National Academy of Sciences of the United States of America 116 (21), pp. 10568 - 10575 (2019)

Schoebel, S.; Mi, W.; Stein, A.; Ovchinnikov, S.; Pavlovicz, R.; DiMaio, F.; Baker, D.; Chambers, M. G.; Su, H.; Li, D. et al.; Rapoport, T. A.; Liao, M.: Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3. Nature 548 (7667), pp. 352 - 355 (2017)

Stein, A.; Ruggiano, A.; Carvalho, P.; Rapoport, T. A.: Key steps in ERAD of luminal ER proteins reconstituted with purified components. Cell 158 (6), pp. 1375 - 1388 (2014)

Hernandez, J. M.; Stein, A.; Behrmann, E.; Riedel, D.; Cypionka, A.; Farsi, Z.; Walla, P. J.; Raunser, S.; Jahn, R.: Membrane fusion intermediates via directional and full assembly of the SNARE complex. Science 336 (6088), pp. 1581 - 1584 (2012)

Li, H.; Pink, M. D.; Murphy, J. G.; Stein, A.; Dell'Acqua, M. L.; Hogan, P. G.: Balanced interactions of calcineurin with AKAP79 regulate Ca2+–calcineurin–NFAT signaling. Nature Structural and Molecular Biology 19, pp. 337 - 345 (2012)

Wiederhold, K.; Klöpper, T. H.; Walter, A. M.; Stein, A.; Kienle, N.; Sörensen, J. B.; Fasshauer, D.: A coiled coil trigger site is essential for rapid binding of synaptobrevin to the SNARE acceptor complex. Journal of Biological Chemistry 285 (28), pp. 21549 - 21559 (2010)

Ellena, J. F.; Liang, B. Y.; Wiktor, M.; Stein, A.; Cafiso, D. S.; Jahn, R.; Tamm, L. K.: Dynamic structure of lipid-bound synaptobrevin suggests a nucleation-propagation mechanism for trans-SNARE complex formation. Proceedings of the National Academy of Sciences of the United States of America 106 (48), pp. 20306 - 20311 (2009)

Domanska, M. K.; Kiessling, V.; Stein, A.; Fasshauer, D.; Tamm, L. K.: Single vesicle millisecond fusion kinetics reveals number of SNARE complexes optimal for fast SNARE-mediated membrane fusion. Journal of Biological Chemistry 284 (46), pp. 32158 - 32166 (2009)

Stein, A.; Jahn, R.: Complexins living up to their name — New light on their role in exocytosis. Neuron 64 (3), pp. 295 - 297 (2009)

Cypionka, A.; Stein, A.; Hernandez, M.; Hippchen, H.; Jahn, R.; Walla, P. J.: Discrimination between docking and fusion of liposomes reconstituted with neuronal SNARE-proteins using FCS. Proceedings of the National Academy of Sciences of the United States of America 106 (44), pp. 18575 - 18580 (2009)

Stein, A.; Weber, G.; Wahl, M. C.; Jahn, R.: Helical extension of the neuronal SNARE complex into the membrane. Nature 460 (7254), pp. 525 - 528 (2009)

Radhakrishnan, A.; Stein, A.; Jahn, R.; Fasshauer, D.: The Ca²⁺ affinity of synaptotagmin 1 is markedly increased by a specific interaction of its C2B domain with phosphatidylinositol 4,5-bisphosphate. Journal of Biological Chemistry 284, pp. 25749 - 25760 (2009)

Barszczewski, M.; Chua, J.; Stein, A.; Winter, U.; Heintzmann, R.; Zilly, F. E.; Fasshauer, D.; Lang, T.; Jahn, R.: A novel site of action for α -SNAP in the SNARE conformational cycle controlling membrane fusion. Molecular Biology of the Cell 19 (3), pp. 776 - 784 (2008)

Stein, A.; Radhakrishnan, A.; Riedel, D.; Fasshauer, D.; Jahn, R.: Synaptotagmin activates membrane fusion through a Ca²⁺-dependent trans interaction with phospholipids. Nature Structure & Molecular Biology 14 (10), pp. 904 - 911 (2007)

Pobbati, A.; Stein, A.; Fasshauer, D.: N- to C-terminal SNARE complex assembly promotes rapid membrane fusion. Science 313, pp. 673 - 676 (2006)

Sakaba, T.; Stein, A.; Jahn, R.; Neher, E.: Distinct kinetic changes in neurotransmitter release after SNARE protein cleavage. Science 309 (5733), pp. 491 - 494 (2005)

Schuette, C. G.; Hatsuzawa, K.; Margittai, M.; Stein, A.; Riedel, D.; Kuester, P.; Koenig, M.; Seidel, C.; Jahn, R.: Determinants of liposome fusion mediated by synaptic SNARE proteins. Proceedings of the National Academy of Sciences of the United States of America 101 (9), pp. 2858 - 2863 (2004)

Vrentzou, A.; Leidner, F.; Schmidt, C. C.; Grubmüller, H.; Stein, A.: UBE2J2 sensitizes the ERAD ubiquitination cascade to changes in membrane lipid saturation. bioRxiv (2025)

Mimoso, T.; Korobeinikov, A.; Stein, A.; Milovanovic, D.; Rizzoli, S. O.; Köster, S.; Reshetniak, S.: Brain-derived synaptic vesicles have an intrinsic ability to sequester tubulin. bioRxiv (2025)