Publikationen

2.

Zeitschriftenartikel

Karagulyan, N.; Thirumalai, A.; Michanski, S.; Qi, Y.; Fang, Q.; Wang, H.; Ortner, N. J.; Striessnig, J.; Strenzke, N.; Wichmann, C. et al.; Hua, Y.; Moser, T.: Gating of hair cell Ca²⁺ channels governs the activity of cochlear neurons. Science Advances 11 (25), eadu7898 (2025)

MPG.PuRe

3.

Zeitschriftenartikel

Groshkova, M.; Alvanos, T.; Qi, Y.; Wang, F.; Wichmann, C.; Hua, Y.; Moser, T.: Investigation of neuromodulation of the endbulb of Held synapse in the cochlear nucleus by serotonin and norepinephrine. Frontiers in Cellular Neuroscience 19, 1575158 (2025)

MPG.PuRe

4.

Zeitschriftenartikel

Thirumalai, A.; Henseler, J.; Enayati, M.; Kusch, K.; Hessler, R.; Moser, T.; Huet, A. T.: Improved optogenetic modification of spiral ganglion neurons for future optical cochlear implants. Theranostics 15 (10), S. 4270 - 4286 (2025)

MPG.PuRe

5.

Zeitschriftenartikel

Schaeper, J. J.; Kampshoff, C. A.; Wolf, B. J.; Roos, L.; Michanski, S.; Ruhwedel, T.; Eckermann, M.; Meyer, A.; Jeschke, M.; Wichmann, C. et al.; Moser, T.; Salditt, T.: 3D virtual histology of rodent and primate cochleae with multi-scale phase-contrast X-ray tomography. Scientific Reports 15, 7933 (2025)

MPG.PuRe

6.

Zeitschriftenartikel

Oestreicher, D.; Malpede, A. M.; Reitmeier, A.; Bräuer, C. P.; Schoch, L.; Strenzke, N.; Pangrsic, T.: Noise-induced ribbon synapse loss in the mouse basal cochlear region does not reduce inner hair cell exocytosis. Frontiers in Cellular Neuroscience 18, 1523978 (2025)

MPG.PuRe

7.

Zeitschriftenartikel

Jaime Tobón, L. M.; Moser, T.: Bridging the gap between presynaptic hair cell function and neural sound encoding. eLife 12, RP93749 (2024)

MPG.PuRe

8.

Zeitschriftenartikel

Oestreicher, D.; Chepurwar, S.; Kusch, K.; Rankovic, V.; Jung, S.; Strenzke, N.; Pangrsic, T.: CaBP1 and 2 enable sustained Ca_V1.3 calcium currents and synaptic transmission in inner hair cells. eLife 13, RP93646 (2024)

MPG.PuRe

9.

Zeitschriftenartikel

Shaib, A. H.; Chouaib, A. A.; Chowdhury, R.; Altendorf, J.; Mihaylov, D.; Zhang, C.; Krah, D.; Imani, V.; Spencer, R. K. W.; Georgiev, S. V. et al.; Mougios, N.; Monga, M.; Reshetniak, S.; Mimoso, T.; Chen, H.; Fatehbasharzad, P.; Crzan, D.; Saal, K.-A.; Alawieh, M. M.; Alawar, N.; Eilts, J.; Kang, J.; Soleimani, A.; Müller, M.; Pape, C.; Alvarez, L.; Trenkwalder, C.; Mollenhauer, B.; Outeiro, T. F.; Köster, S.; Preobraschenski, J.; Becherer, U.; Moser, T.; Boyden, E. S.; Aricescu, A. R.; Sauer, M.; Opazo, F.; Rizzoli, S. O.: One-step nanoscale expansion microscopy reveals individual protein shapes. Nature Biotechnology (2024)

MPG.PuRe

10.

Zeitschriftenartikel

Vona, B.; Wollnik, B.; Strenzke, N.; Moser, T.: Catching up but still miles behind—a patient registry for otoferlin. Experimental and Molecular Medicine 56, S. 1472 - 1473 (2024)

MPG.PuRe

11.

Zeitschriftenartikel

Chen, H.; Monga, M.; Fang, Q.; Slitin, L.; Neef, J.; Chepurwar, S. S.; Netto, R. C. M.; Lezirovitz, K.; Tabith Jr, A.; Benseler, F. et al.; Brose, N.; Kusch, K.; Wichmann, C.; Strenzke, N.; Vona, B.; Preobraschenski, J.; Moser, T.: Ca²⁺ binding to the C₂E domain of otoferlin is required for hair cell exocytosis and hearing. Protein & Cell 15 (4), S. 305 - 312 (2024)

MPG.PuRe

post-print

12.

Zeitschriftenartikel

Hain, P. J. H.; Moser, T.: Optical measurement of glutamate release robustly reports short-term plasticity at a fast central synapse. Frontiers in Molecular Neuroscience 17, 1351280 (2024)

MPG.PuRe

13.

Zeitschriftenartikel

Cepeda, A. P.; Ninov, M.; Neef, J.; Parfentev, I.; Kusch, K.; Reisinger, E.; Jahn, R.; Moser, T.; Urlaub, H.: Proteomic Analysis Reveals the Composition of Glutamatergic Organelles of Auditory Inner Hair Cells. Molecular & Cellular Proteomics 23 (2), 100704 (2024)

MPG.PuRe

14.

Zeitschriftenartikel

Huet, A.; Mager, T.; Gossler, C.; Moser, T.: Toward Optogenetic Hearing Restoration. Annual Review of Neuroscience 47, S. 103 - 121 (2024)

MPG.PuRe

15.

Zeitschriftenartikel

Chen, H.; Fang, Q.; Benseler, F.; Brose, N.; Moser, T.: Probing the role of the C₂F domain of otoferlin. Frontiers in Molecular Neuroscience 16, 1299509 (2023)

MPG.PuRe

16.

Zeitschriftenartikel

Moser, T.; Karagulyan, N.; Neef, J.; Jaime Tobón, L. M.: Diversity matters — extending sound intensity coding by inner hair cells via heterogeneous synapses. The EMBO Journal 42 (23), e114587 (2023)

MPG.PuRe

17.

Zeitschriftenartikel

Khurana, L.; Harczos, T.; Moser, T.; Jablonski, L.: En route to sound coding strategies for optical cochlear implants. iScience 26 (10), 107725 (2023)

MPG.PuRe

18.

Zeitschriftenartikel

Karagulyan, N.; Moser, T.: Synaptic activity is not required for establishing heterogeneity of inner hair cell ribbon synapses. Frontiers in Molecular Neuroscience 16, 1248941 (2023)

MPG.PuRe

19.

Zeitschriftenartikel

Michanski, S.; Kapoor, R.; Steyer, A. M.; Möbius, W.; Früholz, I.; Ackermann, F.; Gueltas, M.; Garner, C. C.; Hamra, F. K.; Neef, J. et al.; Strenzke, N.; Moser, T.; Wichmann, C.: Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing. EMBO Reports 24 (9), e56702 (2023)

MPG.PuRe

20.

Zeitschriftenartikel

Grabner, C.; Futagi, D.; Shi, J.; Bindokas, V.; Kitano, K.; Schwartz, E.A.; DeVries, S.H.: Mechanisms of simultaneous linear and nonlinear computations at the mammalian cone photoreceptor synapse. Nature Communications 14, 3486 (2023)

MPG.PuRe

Full

21.

Zeitschriftenartikel

Zerche, M.; Wrobel, C.; Kusch, K.; Moser, T.; Mager, T.: Channelrhodopsin fluorescent tag replacement for clinical translation of optogenetic hearing restoration. Molecular Therapy: Methods & Clinical Development 29, S. 202 - 212 (2023)

MPG.PuRe

22.

Zeitschriftenartikel

Hunniford, V.; Kuehler, R.; Wolf, B.; Keppeler, D.; Strenzke, N.; Moser, T.: Patient perspectives on the need for improved hearing rehabilitation: A qualitative survey study of German cochlear implant users. Frontiers in Neuroscience 17, 1105562 (2023)

MPG.PuRe

23.

Zeitschriftenartikel

Cantu-Guerra, H. L.; Papazian, M. R.; Gorsky, A. L.; Alekos, N. S.; Caccavano, A.; Karagulyan, N.; Neef, J.; Vicini, S.; Moser, T.; Coate, T. M.: Cochlear hair cell innervation is dependent on a modulatory function of Semaphorin-3A. Developmental Dynamics 252 (1), S. 124 - 144 (2023)

MPG.PuRe

24.

Zeitschriftenartikel

Jaime Tobón, L. M.; Moser, T.: Ca²⁺ regulation of glutamate release from inner hair cells of hearing mice. Proceedings of the National Academy of Sciences of the United States of America 120 (49), e2311539120 (2023)

MPG.PuRe

25.

Zeitschriftenartikel

Michael, M.; Wolf, B. J.; Klinge-Strahl, A.; Jeschke, M.; Moser, T.; Dieter, A.: Devising a framework of optogenetic coding in the auditory pathway: Insights from auditory midbrain recordings. Brain Stimulation 16 (5), S. 1486 - 1500 (2023)

MPG.PuRe

26.

Zeitschriftenartikel

Mittring, A.; Moser, T.; Huet, A. T.: Graded optogenetic activation of the auditory pathway for hearing restoration. Brain Stimulation 16 (2), S. 466 - 483 (2023)

MPG.PuRe

27.

Zeitschriftenartikel

Chakrabarti, R.; Jaime Tobon, L. M.; Slitin, L.; Redondo-Canales, M.; Hoch, G.; Slashcheva, M.; Fritsch, E.; Bodensiek, K.; Özçete, Ö. D.; Gültas, M. et al.; Michanski, S.; Opazo, F.; Neef, J.; Pangrsic, T.; Moser, T.; Wichmann, C.: Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses. eLife 11, e79494 (2022)

MPG.PuRe

post-print

28.

Zeitschriftenartikel

Bosse, N. I.; Abbott, S.; Bracher, J.; Hain, H.; Quilty, B. J.; Jit, M.; Centre for the Mathematical Modelling of Infectious Diseases COVID-19 Working Group; van Leeuwen, E.; Cori, A.; Funk, S.: Comparing human and model-based forecasts of COVID-19 in Germany and Poland. PLoS Computational Biology 18 (9), e1010405 (2022)

MPG.PuRe

29.

Zeitschriftenartikel

Wolf, B. J.; Kusch, K.; Hunniford, V.; Vona, B.; Kuhler, R.; Keppeler, D.; Strenzke, N.; Moser, T.: Is there an unmet medical need for improved hearing restoration? Embo Molecular Medicine 14 (8), e15798 (2022)

MPG.PuRe

30.

Zeitschriftenartikel

Grabner, C.; Jansen, I.; Neef, J.; Weihs, T.; Schmidt, R.; Riedel, D.; Wurm, C. A.; Moser, T.: Resolving the molecular architecture of the photoreceptor active zone with 3D-MINFLUX. Science Advances 8 (28), eabl7560 (2022)

MPG.PuRe

31.

Zeitschriftenartikel

Calapai, A.; Cabrera-Moreno, J.; Moser, T.; Jeschke, M.: Flexible auditory training, psychophysics, and enrichment of common marmosets with an automated, touchscreen-based system. Nature Communications 13 (1), 1648 (2022)

MPG.PuRe

32.

Zeitschriftenartikel

Khurana, L.; Keppeler, D.; Jablonski, L.; Moser, T.: Model-based prediction of optogenetic sound encoding in the human cochlea by future optical cochlear implants. Computational and Structural Biotechnology Journal 20, S. 3621 - 3629 (2022)

MPG.PuRe

33.

Zeitschriftenartikel

Butola, T.; Alvanos, T.; Hintze, A.; Koppensteiner, P.; Kleindienst, D.; Shigemoto, R.; Wichmann, C.; Moser, T.: RIM-Binding Protein 2 organizes Ca2+channel topography and regulates release probability and vesicle replenishment at a fast central synapse. bioRxiv, 435607 (2021)

MPG.PuRe

pre-print

34.

Zeitschriftenartikel

Özçete, Ö. D.; Moser, T.: A sensory cell diversifies its output by varying Ca2+ influx‐release coupling among active zones. EMBO Journal 40 (5), e106010 (2021)

MPG.PuRe

35.

Zeitschriftenartikel

Rankovic, V.; Vogl, C.; Dörje, N. M.; Bahader, I.; Duque-Afonso, C. J.; Thirumalai, A.; Weber, T.; Kusch, K.; Strenzke, N.; Moser, T.: Overloaded adeno-associated virus as a novel gene therapeutic tool for otoferlin-related deafness. Frontiers in Moecular Neuroscience 13, 600051 (2021)

MPG.PuRe

36.

Zeitschriftenartikel

Grabner, C.; Moser, T.: The mammalian rod synaptic ribbon is essential for Cav channel facilitation and ultrafast fusion of the readily releasable pool of vesicles. bioRxiv, 336503 (2020)

MPG.PuRe

pre-print

37.

Zeitschriftenartikel

Keppeler, D.; Schwaerzle, M.; Harczos, T.; Jablonski, L.; Dieter, A.; Wolf, B.; Ayub, S.; Vogl, C.; Wrobel, C.; Hoch, G. et al.; Abdellatif, K.; Jeschke, M.; Rankovic, V.; Paul, O.; Ruther, P.; Moser, T.: Multichannel optogenetic stimulation of the auditory pathway using microfabricated LED cochlear implants in rodents. Science Translational Medicine 12 (553), eabb8086 (2020)

MPG.PuRe

38.

Zeitschriftenartikel

Kroll, J.; Özçete, Ö. D.; Jung, S.; Maritzen, T.; Milosevic, I.; Wichmann, C.; Moser, T.: AP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells. Journal of Cell Science 133 (2), jcs236737 (2020)

MPG.PuRe

39.

Zeitschriftenartikel

Michanski, S.; Smaluch, K.; Steyer, A. M.; Chakrabarti, R.; Setz, C.; Oestreicher, D.; Fischer, C.; Möbius, W.; Moser, T.; Vogl, C. et al.; Wichmann, C.: Mapping developmental maturation of inner hair cell ribbon synapses in the apical mouse cochlea. Proceedings of the National Academy of Sciences of the United States of America 116 (13), S. 6415 - 6424 (2019)

MPG.PuRe

40.

Zeitschriftenartikel

Kroll, J.; Jaime Tobon, L. M.; Vogl, C.; Neef, J.; Kondratiuk, I.; König, M.; Strenzke, N.; Wichmann, C.; Milosevic, I.; Moser, T.: Endophilin-A regulates presynaptic Ca2⁺ influx and synaptic vesicle recycling in auditory hair cells. The EMBO Journal 38 (5), e100116 (2019)

MPG.PuRe

41.

Zeitschriftenartikel

Takago, H.; Oshima-Takago, T.; Moser, T.: Disruption of otoferlin alters the mode of exocytosis at the mouse inner hair cell ribbon synapse. Frontiers in Molecular Neuroscience 11, 492 (2019)

MPG.PuRe

42.

Zeitschriftenartikel

Al‐Moyed, H.; Cepeda, A. P.; Jung, S.; Moser, T.; Kügler, S.; Reisinger, E.: A dual-AAV approach restores fast exocytosis and partially rescues auditory function in deaf otoferlin knock-out mice. EMBO Molecular Medicine 10 (12), e9396 (2018)

MPG.PuRe

43.

Zeitschriftenartikel

Grabner, C.; Moser, T.: Individual synaptic vesicles mediate stimulated exocytosis from cochlear inner hair cells. Proceedings of the National Academy of Sciences of the United States of America 115 (50), S. 12811 - 12816 (2018)

MPG.PuRe

44.

Zeitschriftenartikel

Hagiwara, A.; Kitahara, Y.; Grabner, C.; Vogl, C.; Abe, M.; Kitta, R.; Ohta, K.; Nakamura, K.; Sakimura, K.; Moser, T. et al.; Nishi, A.; Ohtsuka, T.: Cytomatrix proteins CAST and ELKS regulate retinal photoreceptor development and maintenance. Journal of Cell Biology 217 (11), S. 3993 - 4006 (2018)

MPG.PuRe

45.

Zeitschriftenartikel

Brandenburg, S.; Pawlowitz, J.; Fakuade, F. E.; Kownatzki-Danger, D.; Kohl, T.; Mitronova, G.; Scardigli, M.; Neef, J.; Schmidt, C.; Wiedmann, F. et al.; Pavone, F. S.; Sacconi, L.; Kutschka, I.; Sossalla, S.; Moser, T.; Voigt, N.; Lehnart, S. E.: Axial tubule junctions activate atrial Ca²⁺ release across species. Frontiers in Physiology 9, 1227 (2018)

MPG.PuRe

46.

Zeitschriftenartikel

Mager, T.; de la Morena, D. L.; Senn, V.; Schlotte, J.; D´Errico, A.; Feldbauer, K.; Wrobel, C.; Jung, S.; Bodensiek, K.; Rankovic, V. et al.; Browne, L.; Huet, A.; Jüttner, J.; Wood, P. G.; Letzkus, J. J.; Moser, T.; Bamberg, E.: High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics. Nature Communications 9, 1750 (2018)

MPG.PuRe

47.

Zeitschriftenartikel

Neef, J.; Urban, N. T.; Ohn, T. L.; Frank, T.; Jean, P.; Hell, S. W.; Willig, K. I.; Moser, T.: Quantitative optical nanophysiology of Ca²⁺ signaling at inner hair cell active zones. Nature Communications 9, 290 (2018)

MPG.PuRe

48.

Zeitschriftenartikel

Richter, K. N.; Revelo, N. H.; Seitz, K. J.; Helm, M. S.; Sarkar, D.; Saleeb, R. S.; D'Este, E.; Eberle, J.; Wagner, E.; Vogl, C. et al.; Lazaro, D. F.; Richter, F.; Coy‐Vergara, J.; Coceano, G.; Boyden, E. S.; Duncan, R. R.; Hell, S. W.; Lauterbach, M. A.; Lehnart, S. E.; Moser, T.; Outeiro, T.; Rehling, P.; Schwappach, B.; Testa, I.; Zapiec, B.; Rizzoli, S. O.: Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy. EMBO Journal 37 (1), S. 139 - 159 (2018)

MPG.PuRe

49.

Zeitschriftenartikel

Krinner, S.; Butola, T.; Jung, S.; Wichmann, C.; Moser, T.: RIM-binding protein 2 promotes a large number of Ca_V1.3 Ca²⁺-channels and contributes to fast synaptic vesicle replenishment at hair cell active zones. Frontiers in Cellular Neuroscience 11, 334 (2017)

MPG.PuRe

50.

Zeitschriftenartikel

Vogl, C.; Butola, T.; Haag, N.; Hausrat, T. J.; Leitner, M. G.; Moutschen, M.; Lefebvre, P. P.; Speckmann, C.; Garrett, L.; Becker, L. et al.; Fuchs, H.; de Angelis, M. H.; Nietzsche, S.; Kessels, M. M.; Oliver, D.; Kneussel, M.; Kilimann, M. W.; Strenzke, N.: The BEACH protein LRBA is required for hair bundle maintenance in cochlear hair cells and for hearing. EMBO Reports 18 (11), S. 2015 - 2029 (2017)

MPG.PuRe