Publications

Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice.

Gargareta VI, Reuschenbach J, Siems SB, Sun T, Piepkorn L, Mangana C, Späte E, Goebbels S, Huitinga I, Möbius W, Nave KA, Jahn O, Werner HB (2022) eLIFE 11:e77019. doi: 10.7554/eLife.77019.

Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5.

Buscham TJ, Eichel-Vogel MA, Steyer AM, Jahn O, Strenzke N, Dardawal R, Memhave TR, Siems SB, Müller C, Meschkat M, Sun T, Ruhwedel T, Möbius W, Krämer-Albers EM, Boretius S, Nave KA, Werner HB (2022) eLIFE 11:e75523. doi: 10.7554/eLife.75523

 

Proteome Profile of Myelin in the Zebrafish Brain.

Siems SB, Jahn O, Hoodless LJ, Jung RB, Hesse D, Möbius W, Czopka T, Werner HB (2021) Frontiers in Cell and Developmental Biology 9:640169. doi: 10.3389/fcell.2021.640169

 

The CNS Myelin Proteome: Deep Profile and Persistence After Post-mortem Delay.

Jahn O, Siems SB, Kusch K, Hesse D, Jung RB, Liepold T, Uecker M, Sun T, Werner HB (2020) Frontiers in Cellular Neuroscience 14:239. doi: 10.3389/fncel.2020.00239

 

Proteome profile of peripheral myelin in healthy mice and in a neuropathy model.

Siems SB, Jahn O, Eichel MA, Kannaiyan N, Wu LMN, Sherman DL, Kusch K, Hesse D, Jung RB, Fledrich R, Sereda MW, Rossner MJ, Brophy PJ, Werner HB (2020) eLIFE 9:e51406. doi: 10.7554/eLife.51406

 

CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves.

Eichel MA, Gargareta VI, D'Este E, Fledrich R, Kungl T, Buscham TJ, Lüders KA, Miracle C, Jung RB, Distler U, Kusch K, Möbius W, Hülsmann S, Tenzer S, Nave KA, Werner HB (2020) Nature Communications 11:4514. doi: 10.1038/s41467-020-18172-7

 

Myelinating Glia-Specific Deletion of Fbxo7 in Mice Triggers Axonal Degeneration in the Central Nervous System Together with Peripheral Neuropathy.

Joseph S, Vingill S, Jahn O, Fledrich R, Werner HB, Katona I, Möbius W, Mitkovski M, Huang Y, Weis J, Sereda MW, Schulz JB, Nave KA, Stegmüller J (2019) Journal of Neuroscience 39:5606. doi: 10.1523/JNEUROSCI.3094-18.2019

 

Myelin: Methods for Purification and Proteome Analysis.

Erwig MS, Hesse D, Jung RB, Uecker M, Kusch K, Tenzer S, Jahn O, Werner HB (2019) Methods in Molecular Biology 1936:37. doi: 10.1007/978-1-4939-9072-6_3

 

Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin.

Erwig MS, Patzig J, Steyer AM, Dibaj P, Heilmann M, Heilmann I, Jung RB, Kusch K, Möbius W, Jahn O, Nave KA, Werner HB (2019) eLIFE 8:e43888. doi: 10.7554/eLife.43888

 

Partial Immunoblotting of 2D-Gels: A Novel Method to Identify Post-Translationally Modified Proteins Exemplified for the Myelin Acetylome.

Kusch K, Uecker M, Liepold T, Möbius W, Hoffmann C, Neumann H, Werner HB, Jahn O (2017) Proteomes 5:3. doi: 10.3390/proteomes5010003

 

Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction.

Patzig J, Erwig MS, Tenzer S, Kusch K, Dibaj P, Möbius W, Goebbels S, Schaeren-Wiemers N, Nave KA, Werner HB (2016) eLIFE 5:e17119. doi: 10.7554/eLife.17119

 

Myelin proteome analysis: methods and implications for the myelin cytoskeleton.

Jahn, O, Tenzer, S, Bartsch, N, Patzig, J, Werner, HB (2013). In R. Dermietzel (Ed.), The Cytoskeleton: Imaging, isolation, and interaction (pp. 335-353). doi: 10.1007/978-1-62703-266-7_15

 

Molecular evolution of myelin basic protein, an abundant structural myelin component.

Nawaz S, Schweitzer J, Jahn O, Werner HB (2013) Glia 61:1364. doi: 10.1002/glia.22520

 

Systematic approaches to central nervous system myelin.

de Monasterio-Schrader P, Jahn O, Tenzer S, Wichert SP, Patzig J, Werner HB (2012) Cellular and Molecular Life Sciences 69:2879. doi: 10.1007/s00018-012-0958-9. Review

 

Quantitative and integrative proteome analysis of peripheral nerve myelin identifies novel myelin proteins and candidate neuropathy loci.

Patzig J, Jahn O, Tenzer S, Wichert SP, de Monasterio-Schrader P, Rosfa S, Kuharev J, Yan K, Bormuth I, Bremer J, Aguzzi A, Orfaniotou F, Hesse D, Schwab MH, Möbius W, Nave KA, Werner HB (2011) Journal of Neuroscience 31:16369. doi: 10.1523/JNEUROSCI.4016-11.2011

 

Myelin matters: proteomic insights into white matter disorders.

Werner HB, Jahn O (2010) Expert Review of Proteomics 7:159. doi: 10.1586/epr.09.105. Editorial

 

Myelin proteomics: molecular anatomy of an insulating sheath.

Jahn O, Tenzer S, Werner HB (2009) Molecular Neurobiology 40:55. doi: 10.1007/s12035-009-8071-2. Review

 

Proteolipid protein is required for transport of sirtuin 2 into CNS myelin.

Werner HB, Kuhlmann K, Shen S, Uecker M, Schardt A, Dimova K, Orfaniotou F, Dhaunchak A, Brinkmann BG, Möbius W, Guarente L, Casaccia-Bonnefil P, Jahn O, Nave KA (2007) Journal of Neuroscience 27:7717. doi: 10.1523/JNEUROSCI.1254-07.2007

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