Publications
Journal Article (50)
1.
Journal Article
16, pp. 616 - 640 (2024)
Targeting PI3K/Akt/mTOR signaling in rodent models of PMP22 gene-dosage diseases. Embo Molecular Medicine 2.
Journal Article
35 (12), pp. 2136 - 2152.e9 (2023)
Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration. Cell Metabolism 3.
Journal Article
24, pp. 47 - 60 (2021)
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis. Nature Neuroscience 4.
Journal Article
98 (10), pp. 1933 - 1952 (2020)
Synergistic PXT3003 therapy uncouples neuromuscular function from dysmyelination in male Charcot–Marie–Tooth disease type 1A (CMT1A) rats. Journal of Neuroscience Research 5.
Journal Article
27 (8), pp. 1390 - 1396 (2020)
Pregnancy outcome in Charcot–Marie–Tooth disease: results of the CMT‐NET cohort study in Germany. European Journal of Neurology 6.
Journal Article
9, e51406 (2020)
Proteome profile of peripheral myelin in healthy mice and in a neuropathy model. eLife 7.
Journal Article
39 (28), pp. 5606 - 5626 (2019)
Myelinating glia-specific deletion of Fbxo7 in mice triggers axonal degeneration in the central nervous system together with peripheral neuropathy. The Journal of Neuroscience 8.
Journal Article
10, 1467 (2019)
NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies. Nature Communications 9.
Journal Article
14 (1), e0209752 (2019)
Early short-term PXT3003 combinational therapy delays disease onset in a transgenic rat model of Charcot-Marie-Tooth disease 1A (CMT1A). PLoS One 10.
Journal Article
9, 3025 (2018)
Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy. Nature Communications 11.
Journal Article
88 (11), pp. 941 - 952 (2017)
Biomarkers predict outcome in Charcot-Marie-Tooth disease 1A. Journal of Neurology, Neurosurgery & Psychiatry 12.
Journal Article
6, e23332 (2017)
Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy. eLife 13.
Journal Article
8, 17 (2017)
Rho kinase inhibition with Fasudil in SOD1(G93A) mouse model of Amyotrophic Lateral Sclerosis - symptomatic treatment potential after diesease onset. Frontiers in Pharmacology 14.
Journal Article
95 (11), pp. 145 - 157 (2016)
Tolerability and efficacy study of P2X7 inhibition in experimental Charcot-Marie-Tooth type 1A (CMT1A) neuropathy. Neurobiology of Disease 15.
Journal Article
19 (8), pp. 1050 - 1059 (2016)
Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair. Nature Neuroscience 16.
Journal Article
18 (5), pp. 443 - 451 (2016)
The role of combined SNV and CNV burden in patients with distal symmetric polyneuropathy. Genetics in Medicine 17.
Journal Article
64 (1), pp. 155 - 174 (2016)
Proteolipid protein modulates preservation of peripheral axons and premature death when myelin protein zero is lacking. Glia 18.
Journal Article
2 (8), pp. 787 - 796 (2015)
Curcumin therapy in a Plp1 transgenic mouse model of Pelizaeus-Merzbacher disease. Annals of Clinical and Translational Neurology 19.
Journal Article
4, 53 (2015)
A brief review of recent Charcot-Marie-Tooth research and priorities. Faculty of 1000 Research 20.
Journal Article
9 (1), 201 (2014)
Polytherapy with a combination of three repurposed drugs (PXT3003) down-regulates Pmp22 over-expression and improves myelination, axonal and functional parameters in models of CMT1A neuropathy. Orphanet Journal of Rare Diseases 21.
Journal Article
24 (11), pp. 1003 - 1017 (2014)
Selected items from the Charcot-Marie-Tooth (CMT) neuropathy score and secondary clinical outcome measures serve as sensitive clinical markers of disease severity in CMT1A patients. Neuromuscular Disorders 22.
Journal Article
34 (44), pp. 14506 - 14516 (2014)
Annexin A2 regulates TRPA1-dependent nociception. Journal of Neuroscience 23.
Journal Article
20 (9), pp. 1055 - 1061 (2014)
Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A. Nature Medicine 24.
Journal Article
94 (4), pp. 533 - 546 (2014)
Progesterone antagonist therapy in a Pelizaeus-Merzbacher mouse model. The American Journal of Human Genetics 25.
Journal Article
62 (2), pp. 217 - 232 (2014)
Rho kinase inhibition modulates microglia activation and improves survival in a model of amyotrophic lateral sclerosis. Glia 26.
Journal Article
16 (1), pp. 48 - 54 (2013)
A role for Schwann cell-derived neuregulin-1 in remyelination. Nature Neuroscience 27.
Journal Article
102 (1), pp. 89 - 113 (2012)
Murine therapeutic models for Charcot-Marie-Tooth (CMT) disease. British Medical Bulletin 28.
Journal Article
4 (6), pp. 486 - 499 (2012)
Genetic disruption of Pten in a novel mouse model of tomaculous neuropathy. Embo Molecular Medicine 29.
Journal Article
485 (7399), pp. 517 - 521 (2012)
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature 30.
Journal Article
109 (10), pp. 3973 - 3978 (2012)
Lithium enhances remyelination of peripheral nerves. Proceedings of the National Academy of Sciences of the United States of America 31.
Journal Article
135 (1), pp. 72 - 87 (2012)
A rat model of Charcot-Marie-Tooth disease 1A recapitulates disease variability and supplies biomarkers of axonal loss in patients. Brain 32.
Journal Article
31 (47), pp. 17180 - 17192 (2011)
Sodium-dependent vitamin C transporter 2 deficiency causes hypomyelination and extracellular matrix defects in the peripheral nervous system. The Journal of Neuroscience 33.
Journal Article
42 (1), pp. 1 - 8 (2011)
The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration. Neurobiology of Disease 34.
Journal Article
585 (14), pp. 2205 - 2211 (2011)
A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity. FEBS Letters 35.
Journal Article
10 (4), pp. 275 - 287 (2009)
Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models. Neurogenetics 36.
Journal Article
87 (15), pp. 3465 - 3479 (2009)
The SNARE protein SNAP-29 interacts with the GTPase Rab3A: Implications for membrane trafficking in myelinating glia. Journal of Neuroscience Research 37.
Journal Article
66 (3), pp. 355 - 365 (2009)
Propagation of spreading depression inversely correlates with cortical myelin content. Annals of Neurology 38.
Journal Article
59 (4), pp. 581 - 595 (2008)
Neuregulin-1/ErbB Signaling Serves Distinct Functions in Myelination of the Peripheral and Central Nervous System. Neuron 39.
Journal Article
210 (1), pp. 137 - 143 (2008)
Gadofluorine M-enhanced magnetic resonance nerve imaging: Comparison between acute inflammatory and chronic degenerative demyelination in rats. Experimental Neurology 40.
Journal Article
3 (8), pp. 453 - 464 (2007)
Mechanisms of Disease: inherited demyelinating neuropathies - from basic to clinical research. Nature Clinical Practice Neurology 41.
Journal Article
64 (5), pp. 706 - 713 (2007)
Hereditary spastic paraplegia 3A associated with axonal neuropathy. Archives of Neurology 42.
Journal Article
61 (1), pp. 61 - 72 (2007)
Antiprogesterone therapy uncouples axonal loss from demyelination in a transgenic rat model of CMT1A neuropathy. Annals of Neurology 43.
Journal Article
28 (1), pp. 77 - 88 (2006)
Myelin disorders: causes and perspectives of Charcot-Marie-Tooth neuropathy. Journal of Molecular Neuroscience 44.
Journal Article
8 (1-2), pp. 205 - 215 (2006)
Animal models of Charcot-Marie-Tooth disease type 1A. Neuromolecular Medicine 45.
Journal Article
28 (4), pp. 703 - 714 (2005)
Experimental Charcot-Marie-Tooth type 1A: A cDNA microarrays analysis. Molecular and Cellular Neuroscience 46.
Journal Article
1, pp. 25 - 30 (2005)
Genetische Defekte der Myelinbildung: Molekulare Pathogenese der Charcot-Marie-Tooth Neuropathie (CMT1A). Neuroforum 47.
Journal Article
190 (1), pp. 213 - 223 (2004)
Early abnormalities in sciatic nerve function and structure in a rat model of Charcot-Marie-Tooth type 1A disease. Experimental Neurology 48.
Journal Article
304 (5671), pp. 700 - 703 (2004)
Axonal Neuregulin-1 Regulates Myelin Sheath Thickness. Science 49.
Journal Article
9 (12), pp. 1533 - 1537 (2003)
Therapeutic administration of progesterone antagonist in a model of Charcot-Marie-Tooth disease (CMT-1A). Nature Medicine 50.
Journal Article
21 (3), pp. 920 - 933 (2001)
The AN2 Protein Is a Novel Marker for the Schwann Cell Lineage Expressed by Immature and Nonmyelinating Schwann Cells. The Journal of Neuroscience