Publications
Journal Article (52)
1.
Journal Article
Targeting PI3K/Akt/mTOR signaling in rodent models of PMP22 gene-dosage diseases. Embo Molecular Medicine 16, pp. 616 - 640 (2024)
2.
Journal Article
Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration. Cell Metabolism 35 (12), pp. 2136 - 2152.e9 (2023)
3.
Journal Article
Location matters: hexokinase 1 in glucose metabolism and inflammation. Trends in Endocrinology & Metabolism 33 (10), pp. 665 - 667 (2022)
4.
Journal Article
Ketogenic diet uncovers differential metabolic plasticity of brain cells. Science Advances 8 (37), eabo7639 (2022)
5.
Journal Article
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis. Nature Neuroscience 24, pp. 47 - 60 (2021)
6.
Journal Article
Synergistic PXT3003 therapy uncouples neuromuscular function from dysmyelination in male Charcot–Marie–Tooth disease type 1A (CMT1A) rats. Journal of Neuroscience Research 98 (10), pp. 1933 - 1952 (2020)
7.
Journal Article
Pregnancy outcome in Charcot–Marie–Tooth disease: results of the CMT‐NET cohort study in Germany. European Journal of Neurology 27 (8), pp. 1390 - 1396 (2020)
8.
Journal Article
Proteome profile of peripheral myelin in healthy mice and in a neuropathy model. eLife 9, e51406 (2020)
9.
Journal Article
Myelinating glia-specific deletion of Fbxo7 in mice triggers axonal degeneration in the central nervous system together with peripheral neuropathy. The Journal of Neuroscience 39 (28), pp. 5606 - 5626 (2019)
10.
Journal Article
NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies. Nature Communications 10, 1467 (2019)
11.
Journal Article
Early short-term PXT3003 combinational therapy delays disease onset in a transgenic rat model of Charcot-Marie-Tooth disease 1A (CMT1A). PLoS One 14 (1), e0209752 (2019)
12.
Journal Article
Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy. Nature Communications 9, 3025 (2018)
13.
Journal Article
Biomarkers predict outcome in Charcot-Marie-Tooth disease 1A. Journal of Neurology, Neurosurgery & Psychiatry 88 (11), pp. 941 - 952 (2017)
14.
Journal Article
Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy. eLife 6, e23332 (2017)
15.
Journal Article
Rho kinase inhibition with Fasudil in SOD1(G93A) mouse model of Amyotrophic Lateral Sclerosis - symptomatic treatment potential after diesease onset. Frontiers in Pharmacology 8, 17 (2017)
16.
Journal Article
Tolerability and efficacy study of P2X7 inhibition in experimental Charcot-Marie-Tooth type 1A (CMT1A) neuropathy. Neurobiology of Disease 95 (11), pp. 145 - 157 (2016)
17.
Journal Article
Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair. Nature Neuroscience 19 (8), pp. 1050 - 1059 (2016)
18.
Journal Article
The role of combined SNV and CNV burden in patients with distal symmetric polyneuropathy. Genetics in Medicine 18 (5), pp. 443 - 451 (2016)
19.
Journal Article
Proteolipid protein modulates preservation of peripheral axons and premature death when myelin protein zero is lacking. Glia 64 (1), pp. 155 - 174 (2016)
20.
Journal Article
Curcumin therapy in a Plp1 transgenic mouse model of Pelizaeus-Merzbacher disease. Annals of Clinical and Translational Neurology 2 (8), pp. 787 - 796 (2015)
21.
Journal Article
A brief review of recent Charcot-Marie-Tooth research and priorities. Faculty of 1000 Research 4, 53 (2015)
22.
Journal Article
Polytherapy with a combination of three repurposed drugs (PXT3003) down-regulates Pmp22 over-expression and improves myelination, axonal and functional parameters in models of CMT1A neuropathy. Orphanet Journal of Rare Diseases 9 (1), 201 (2014)
23.
Journal Article
Selected items from the Charcot-Marie-Tooth (CMT) neuropathy score and secondary clinical outcome measures serve as sensitive clinical markers of disease severity in CMT1A patients. Neuromuscular Disorders 24 (11), pp. 1003 - 1017 (2014)
24.
Journal Article
Annexin A2 regulates TRPA1-dependent nociception. Journal of Neuroscience 34 (44), pp. 14506 - 14516 (2014)
25.
Journal Article
Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A. Nature Medicine 20 (9), pp. 1055 - 1061 (2014)
26.
Journal Article
Progesterone antagonist therapy in a Pelizaeus-Merzbacher mouse model. The American Journal of Human Genetics 94 (4), pp. 533 - 546 (2014)
27.
Journal Article
Rho kinase inhibition modulates microglia activation and improves survival in a model of amyotrophic lateral sclerosis. Glia 62 (2), pp. 217 - 232 (2014)
28.
Journal Article
A role for Schwann cell-derived neuregulin-1 in remyelination. Nature Neuroscience 16 (1), pp. 48 - 54 (2013)
29.
Journal Article
Murine therapeutic models for Charcot-Marie-Tooth (CMT) disease. British Medical Bulletin 102 (1), pp. 89 - 113 (2012)
30.
Journal Article
Genetic disruption of Pten in a novel mouse model of tomaculous neuropathy. Embo Molecular Medicine 4 (6), pp. 486 - 499 (2012)
31.
Journal Article
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature 485 (7399), pp. 517 - 521 (2012)
32.
Journal Article
Lithium enhances remyelination of peripheral nerves. Proceedings of the National Academy of Sciences of the United States of America 109 (10), pp. 3973 - 3978 (2012)
33.
Journal Article
A rat model of Charcot-Marie-Tooth disease 1A recapitulates disease variability and supplies biomarkers of axonal loss in patients. Brain 135 (1), pp. 72 - 87 (2012)
34.
Journal Article
Sodium-dependent vitamin C transporter 2 deficiency causes hypomyelination and extracellular matrix defects in the peripheral nervous system. The Journal of Neuroscience 31 (47), pp. 17180 - 17192 (2011)
35.
Journal Article
The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration. Neurobiology of Disease 42 (1), pp. 1 - 8 (2011)
36.
Journal Article
A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity. FEBS Letters 585 (14), pp. 2205 - 2211 (2011)
37.
Journal Article
Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models. Neurogenetics 10 (4), pp. 275 - 287 (2009)
38.
Journal Article
The SNARE protein SNAP-29 interacts with the GTPase Rab3A: Implications for membrane trafficking in myelinating glia. Journal of Neuroscience Research 87 (15), pp. 3465 - 3479 (2009)
39.
Journal Article
Propagation of spreading depression inversely correlates with cortical myelin content. Annals of Neurology 66 (3), pp. 355 - 365 (2009)
40.
Journal Article
Neuregulin-1/ErbB Signaling Serves Distinct Functions in Myelination of the Peripheral and Central Nervous System. Neuron 59 (4), pp. 581 - 595 (2008)
41.
Journal Article
Gadofluorine M-enhanced magnetic resonance nerve imaging: Comparison between acute inflammatory and chronic degenerative demyelination in rats. Experimental Neurology 210 (1), pp. 137 - 143 (2008)
42.
Journal Article
Mechanisms of Disease: inherited demyelinating neuropathies - from basic to clinical research. Nature Clinical Practice Neurology 3 (8), pp. 453 - 464 (2007)
43.
Journal Article
Hereditary spastic paraplegia 3A associated with axonal neuropathy. Archives of Neurology 64 (5), pp. 706 - 713 (2007)
44.
Journal Article
Antiprogesterone therapy uncouples axonal loss from demyelination in a transgenic rat model of CMT1A neuropathy. Annals of Neurology 61 (1), pp. 61 - 72 (2007)
45.
Journal Article
Myelin disorders: causes and perspectives of Charcot-Marie-Tooth neuropathy. Journal of Molecular Neuroscience 28 (1), pp. 77 - 88 (2006)
46.
Journal Article
Animal models of Charcot-Marie-Tooth disease type 1A. Neuromolecular Medicine 8 (1-2), pp. 205 - 215 (2006)
47.
Journal Article
Experimental Charcot-Marie-Tooth type 1A: A cDNA microarrays analysis. Molecular and Cellular Neuroscience 28 (4), pp. 703 - 714 (2005)
48.
Journal Article
Genetische Defekte der Myelinbildung: Molekulare Pathogenese der Charcot-Marie-Tooth Neuropathie (CMT1A). Neuroforum 1, pp. 25 - 30 (2005)
49.
Journal Article
Early abnormalities in sciatic nerve function and structure in a rat model of Charcot-Marie-Tooth type 1A disease. Experimental Neurology 190 (1), pp. 213 - 223 (2004)
50.
Journal Article
Axonal Neuregulin-1 Regulates Myelin Sheath Thickness. Science 304 (5671), pp. 700 - 703 (2004)