Publications of R. Lührmann
All genres
Journal Article (193)
2013
Journal Article
341 (6141), pp. 80 - 84 (2013)
Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8. Science
Journal Article
19 (7), pp. 902 - 915 (2013)
Molecular dissection of step 2 catalysis of yeast pre-mRNA splicing investigated in a purified system. RNA
Journal Article
27 (5), pp. 525 - 540 (2013)
Structural basis for dual roles of Aar2p in U5 snRNP assembly. Genes and Development
Journal Article
27 (4), pp. 413 - 428 (2013)
Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system. Genes and Development 2012
Journal Article
26 (23), pp. 2422 - 2434 (2012)
The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA. Genes and Development
Journal Article
109 (43), pp. 17418 - 17423 (2012)
Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome. Proceedings of the National Academy of Sciences of the United States of America
Journal Article
18 (9), pp. 1605 - 1611 (2012)
Molecular architecture of Zinc chelating small molecules that inhibit spliceosome assembly at an early stage. RNA
Journal Article
3, 994 (2012)
Retention of posttranscriptional spliceosomes in nuclear speckles until splicing completion. Nature communications
Journal Article
18 (7), pp. 1347 - 1357 (2012)
Antisense-targeted immuno-EM localization of the pre-mRNA path in the spliceosomal C complex. RNA
Journal Article
31 (6), pp. 1591 - 1604 (2012)
Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre. EMBO Journal
Journal Article
13 (5), pp. 640 - 644 (2012)
Psoromic acid derivatives: A new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay. ChemBioChem
Journal Article
45 (4), pp. 567 - 580 (2012)
Dynamic protein-protein interaction wiring of the human spliceosome. Molecular Cell
Journal Article
18 (6), pp. 1244 - 1256 (2012)
Prp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS. RNA
Journal Article
31 (9), pp. 2222 - 2234 (2012)
Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein. EMBO Journal 2011
Journal Article
17 (9), pp. 1655 - 1663 (2011)
Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31. RNA
Journal Article
31 (13), pp. 2667 - 2682 (2011)
Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method. Molecular and Cellular Biology
Journal Article
286 (12), pp. 10126 - 10136 (2011)
Synthesis and characterization of pseudocantharidins, novel phosphatase modulators that promote the inclusion of exon 7 into the SMN (survival of motoneuron) pre-mRNA. Journal of Biological Chemistry
Journal Article
331 (6018), pp. 760 - 764 (2011)
HSPC117 is the essential subunit of a human tRNA splicing ligase complex. Science 2010
Journal Article
40 (6), pp. 927 - 938 (2010)
3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core. Molecular Cell
Journal Article
16 (12), pp. 2384 - 2403 (2010)
Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis. RNA