Publications of C. L. Will
All genres
Journal Article (63)
21.
Journal Article
21 (11), pp. 1993 - 2005 (2015)
Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5‘ splice site. RNA 22.
Journal Article
22 (2), pp. 138 - 144 (2015)
The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes. Nature Structural and Molecular Biology 23.
Journal Article
11 (4), pp. 298 - 312 (2014)
Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans. RNA Biology 24.
Journal Article
8 (9), e74851 (2013)
The Prp19 complex directly functions in mitotic spindle assembly. PLoS One 25.
Journal Article
341 (6141), pp. 80 - 84 (2013)
Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8. Science 26.
Journal Article
26 (23), pp. 2422 - 2434 (2012)
The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA. Genes and Development 27.
Journal Article
3, 994 (2012)
Retention of posttranscriptional spliceosomes in nuclear speckles until splicing completion. Nature communications 28.
Journal Article
45 (4), pp. 567 - 580 (2012)
Dynamic protein-protein interaction wiring of the human spliceosome. Molecular Cell 29.
Journal Article
31 (13), pp. 2667 - 2682 (2011)
Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method. Molecular and Cellular Biology 30.
Journal Article
331 (6018), pp. 760 - 764 (2011)
HSPC117 is the essential subunit of a human tRNA splicing ligase complex. Science 31.
Journal Article
16 (12), pp. 2384 - 2403 (2010)
Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis. RNA 32.
Journal Article
30 (9), pp. 2105 - 2119 (2010)
Molecular architecture of the human Prp19/CDC5L complex. Molecular and Cellular Biology 33.
Journal Article
38 (2), pp. 223 - 235 (2010)
Exon definition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexes. Molecular Cell 34.
Journal Article
37 (6), pp. 821 - 833 (2010)
An ancient mechanism for splicing control: U11 snRNP as an activator of alternative splicing. Molecular Cell 35.
Journal Article
17 (2), pp. 216 - 222 (2010)
Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation. Nature Structural and Molecular Biology 36.
Journal Article
136 (4), pp. 701 - 718 (2009)
The spliceosome: design principles of a dynamic RNP machine. Cell 37.
Journal Article
29 (1), pp. 281 - 301 (2009)
Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Molecular and Cellular Biology 38.
Journal Article
105, pp. 8655 - 8660 (2008)
Minor spliceosome components are predominantly localized in the nucleus. Proceedings of the National Academy of Sciences of the United States of America 39.
Journal Article
28 (10), pp. 3548 - 3560 (2008)
The U11-48K protein contacts the 5' splice site of U12-Type introns and the U11-59K protein. Molecular and Cellular Biology 40.
Journal Article
452 (7189), pp. 846 - 850 (2008)
Isolation of an active step I spliceosome and composition of its RNP core. Nature