Publikationen von S. Ort

Wang, Y.; Telmer, C. A.; Schmidt, B. F.; Franke, J. D.; Ort, S.; Arndt-Jovin, D. J.; Bruchez, M. P.: Fluorogen activating protein–affibody probes: modular, no-wash measurement of epidermal growth factor receptors. Bioconjugate Chemistry 26 (1), S. 137 - 144 (2015)

Hazra, S.; Szewczak, A.; Ort, S.; Konrad, M.; Lavie, A.: Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release. Biochemistry 50 (14), S. 2870 - 2880 (2011)

Hazra, S.; Ort, S.; Konrad, M.; Lavie, A.: Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues. Biochemistry 49 (31), S. 6784 - 6790 (2010)

Hazra, S.; Sabini, E.; Ort, S.; Konrad, M.; Lavie, A.: Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase. Biochemistry 48 (6), S. 1256 - 1263 (2009)

Sabini, E.; Hazra, S.; Ort, S.; Konrad, M.; Lavie, A.: Structural basis for substrate promiscuity of dCK. Journal of Molecular Biology 378 (3), S. 607 - 621 (2008)

McSorley, T.; Ort, S.; Hazra, S.; Lavie, A.; Konrad, M.: Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analogues. FEBS Letters 582 (5), S. 720 - 724 (2008)

Sekulic, N.; Dietrich, K.; Paarmann, I.; Ort, S.; Konrad, M.; Lavie, A.: Elucidation of the active conformation of the APS-kinase domain of human PAPS synthetase 1. Journal of Molecular Biology 367 (2), S. 488 - 500 (2007)

Godsey, M. H.; Ort, S.; Sabini, E.; Konrad, M.; Lavie, A.: Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: Illuminating the role of main-chain reorganization. Biochemistry 45 (2), S. 452 - 461 (2006)

Segura-Pena, D.; Sekulic, N.; Ort, S.; Konrad, M.; Lavie, A.: Substrate-induced conformational changes in human UMP/CMP kinase. Journal of Biological Chemistry 279 (32), S. 33882 - 33889 (2004)

Sabini, E.; Ort, S.; Monnerjahn, C.; Konrad, M.; Lavie, A.: Structure of human dCK suggests strategies to improve anticancer and antiviral therapy. Nature Structural Biology 10 (7), S. 513 - 519 (2003)

Konrad, M.; McSorley, T.; Lavie, A.; Ort, S.: Design and intracellular delivery of enzymes to enhance metabolic activation of prodrugs and improve anticancer therapy. FEBS Journal 275 (Suppl. 1), S. 168 - 168 (2008)

Konrad, M.; Ort, S.; Monnerjahn, C.; Lavie, A.: Engineering of nucleoside kinases to improve the activation of nucleoside analog prodrugs. FEBS Journal 273 (Suppl. 1), S. 50 - 50 (2006)

Segura, D.; Sekulic, N.; Ort, S.; Konrad, M.; Lavie, A.: Substrate-induced conformational changes in human UMP/CMP kinase. Protein Science 13 (Suppl. 1), S. 190 - 190 (2004)

Ort, S.: Proteindesign zur Verbesserung des Nukleosidanaloga-Umsatzes in menschlichen Zellen: Desoxycytidin-Kinase und UMP/CMP-Kinase. Dissertation, Universität Göttingen, Göttingen (2005)