Publications of R. Lührmann

Anokhina, M.; Bessonov, S.; Miao, Z. C.; Westhof, E.; Hartmuth, K.; Lührmann, R.: RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core. EMBO Journal 32 (21), pp. 2804 - 2818 (2013)

Hofmann, J. C.; Tegha-Dunghu, J.; Dräger, S.; Will, C. L.; Lührmann, R.; Gruss, O. J.: The Prp19 complex directly functions in mitotic spindle assembly. PLoS One 8 (9), e74851 (2013)

Mozaffari-Jovin, S.; Wandersleben, T.; Santos, K. F.; Will, C. L.; Lührmann, R.; Wahl, M. C.: Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8. Science 341 (6141), pp. 80 - 84 (2013)

Ohrt, T.; Odenwälder, P.; Dannenberg, J.; Prior , M.; Warkocki, Z.; Schmitzova, J.; Karaduman, R.; Gregor, I.; Enderlein, J.; Fabrizio, P. et al.; Lührmann, R.: Molecular dissection of step 2 catalysis of yeast pre-mRNA splicing investigated in a purified system. RNA 19 (7), pp. 902 - 915 (2013)

Weber, G.; Cristao, V. F.; Santos, K. F.; Mozaffari-Jovin, S.; Heroven, A. C.; Holton, N.; Lührmann, R.; Beggs, J. D.; Wahl, M. C.: Structural basis for dual roles of Aar2p in U5 snRNP assembly. Genes and Development 27 (5), pp. 525 - 540 (2013)

Fourmann, J. B.; Schmitzova, J.; Christian, H.; Urlaub, H.; Ficner, R.; Boon, K. L.; Fabrizio, P.; Lührmann, R.: Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system. Genes and Development 27 (4), pp. 413 - 428 (2013)

Mozaffari-Jovin, S.; Santos, K. F.; Hsiao, H. H.; Will, C. L.; Urlaub, H.; Wahl, M. C.; Lührmann, R.: The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA. Genes and Development 26 (23), pp. 2422 - 2434 (2012)

Santos , K. F.; Mozaffari-Jovin, S.; Weber , G.; Pena, V.; Lührmann, R.; Wahl, M. C.: Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome. Proceedings of the National Academy of Sciences of the United States of America 109 (43), pp. 17418 - 17423 (2012)

Patil, V.; Canzoneri, J. C.; Samatov, T. R.; Lührmann, R.; Oyelere, A. K.: Molecular architecture of Zinc chelating small molecules that inhibit spliceosome assembly at an early stage. RNA 18 (9), pp. 1605 - 1611 (2012)

Girard, C.; Will, C. L.; Peng, J.; Makarov, E. M.; Kastner, B.; Lemm, I.; Urlaub, H.; Hartmuth, K.; Lührmann, R.: Retention of posttranscriptional spliceosomes in nuclear speckles until splicing completion. Nature communications 3, 994 (2012)

Wolf, E.; Kastner, B.; Lührmann, R.: Antisense-targeted immuno-EM localization of the pre-mRNA path in the spliceosomal C complex. RNA 18 (7), pp. 1347 - 1357 (2012)

Rasche, N.; Dybkov, O.; Schmitzova, J.; Akyildiz, B.; Fabrizio, P.; Lührmann, R.: Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre. EMBO Journal 31 (6), pp. 1591 - 1604 (2012)

Samatov, T. R.; Wolf, A.; Odenwälder, P.; Bessonov, S.; Deraeve, C.; Bon, R. S.; Waldmann, H.; Lührmann, R.: Psoromic acid derivatives: A new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay. ChemBioChem 13 (5), pp. 640 - 644 (2012)

Hegele, A.; Kamburov, A.; Grossmann, A.; Sourlis, C.; Wowro, S.; Weimann, M.; Will, C. L.; Pena, V.; Lührmann, R.; Stelzl, U.: Dynamic protein-protein interaction wiring of the human spliceosome. Molecular Cell 45 (4), pp. 567 - 580 (2012)

Ohrt, T.; Prior, M.; Dannenberg, J.; Odenwälder, P.; Dybkov, O.; Rasche, N.; Schmitzova, J.; Gregor, I.; Fabrizio, P.; Enderlein, J. et al.; Lührmann, R.: Prp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS. RNA 18 (6), pp. 1244 - 1256 (2012)

Schmitzova, J.; Rasche, N.; Dybkov, O.; Kramer, K.; Fabrizio, P.; Urlaub, H.; Lührmann, R.; Pena, V.: Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein. EMBO Journal 31 (9), pp. 2222 - 2234 (2012)

Liu, S.; Ghalei, H.; Lührmann, R.; Wahl, M.: Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31. RNA 17 (9), pp. 1655 - 1663 (2011)

Agafonov, D. E.; Deckert, J.; Wolf, E.; Odenwälder, P.; Bessonov, S.; Will, C. L.; Urlaub, H.; Lührmann, R.: Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method. Molecular and Cellular Biology 31 (13), pp. 2667 - 2682 (2011)

Zhang, Z.; Kelemen, O.; van Santen, M. A.; Yelton, S. M.; Wendlandt, A. E.; Sviripa, V. M.; Bollen, M.; Beullens, M.; Urlaub, H.; Lührmann, R. et al.; Watt, D. S.; Stamm, S.: Synthesis and characterization of pseudocantharidins, novel phosphatase modulators that promote the inclusion of exon 7 into the SMN (survival of motoneuron) pre-mRNA. Journal of Biological Chemistry 286 (12), pp. 10126 - 10136 (2011)

Popow, J.; Englert, M.; Weitzer, S.; Schleiffer, A.; Mierzwa, B.; Mechtler, K.; Trowitzsch, S.; Will, C. L.; Lührmann, R.; Soell, D. et al.; Martinez, J.: HSPC117 is the essential subunit of a human tRNA splicing ligase complex. Science 331 (6018), pp. 760 - 764 (2011)