The role of Kv10.1 potassium channel in cancer

Research report (imported) 2016 - Max Planck Institute for Multidisciplinary Sciences

Stühmer, Walter; Pardo, Luis A.
Molekulare Biologie Neuronaler Signale, Emeritusgruppe Arbeitsgruppe Onko-Physiologie
Ion channels are membrane proteins that regulate cellular processes by transmitting signals across membranes. Thus it is not surprising that they are also involved in cancer. In this respect, Kv10.1 is the most intensively studied potassium channel. It is overexpressed in over 70% of all cancer forms, and its expression level is up- and down-regulated during the cell cycle. This genetic regulation happens at the centre of signalling cascades involved in cancer and cell division regulation. Consequently, Kv10.1 represents a novel target for cancer treatment.

For the full text, see the German version.

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