Sip1 Transcription Factor as a Key Regulator of Hippocampus Development in the Mouse

Research report (imported) 2005 - Max Planck Institute for Multidisciplinary Sciences

Authors
Miquelajauregui, Amaya; Tarabykin, Victor
Departments
Molekulare Biologie neuronaler Signale (Prof. Dr. Walter Stühmer)
MPI für experimentelle Medizin, Göttingen
Summary
SIP1 is a transcription factor that has been implicated in the genesis of Mowat-Wilson syndrome – a disease that affects normal brain development in humans. In order to uncover molecular mechanisms of Sip1 gene action scientists of the MPI for experimental medicine created a mutant mouse as a model for the syndrome. In this mouse Sip1 gene was inactivated in the cerebral cortex only, while in other organs it remained intact. The mutant mice showed loss of the entire hippocampus, which was based on elevated cell death and decreased proliferation during development.

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