Stock, C., and Pardo , L.A., eds. (2021). Transportome Malfunction in the Cancer Spectrum (Springer).

Ghazaryan, N., Movsisyan, N., Macedo, J.C., Vaz, S., Ayvazyan, N., Pardo, L., and Logarinho, E. (2021). Macrovipera lebetina obtusa Snake Venom as a Modulator of Antitumor Effect in S-180 Sarcoma Mouse Model. Mol. Biol. 10.1134/s0026893321020217.

Gubic, S., Hendrickx, L.A., Toplak, Z., Sterle, M., Peigneur, S., Tomasic, T., Pardo, L.A., Tytgat, J., Zega, A., and Masic, L.P. (2021). Discovery of KV 1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges. Med Res Rev. 10.1002/med.21800.

Perdersen, S.F., Flinck, M., and Pardo, L.A. (2021). The Interplay between Dysregulated Ion Transport and Mitochondrial Architecture as a Dangerous Liaison in Cancer. Int J Mol Sci 22, 5209. 10.3390/ijms22105209.

Toplak, Z., Hendrickx, L.A., Abdelaziz, R., Shi, X., Peigneur, S., Tomasic, T., Tytgat, J., Peterlin-Masic, L., and Pardo, L.A. (2021). Overcoming challenges of HERG potassium channel liability through rational design: Eag1 inhibitors for cancer treatment. Med Res Rev. 10.1002/med.21808.

Toplak, Ž., Hendrickx, L.A., Gubič, Š., Možina, Š., Žegura, B., Štern, A., Novak, M., Shi, X., Peigneur, S., Tytgat, J., et al. (2021). 3D Pharmacophore-Based Discovery of Novel KV10.1 Inhibitors with Antiproliferative Activity. Cancers 13, 1244.

Toplak, Ž., Merzel, F., Pardo, L.A., Peterlin Mašič, L., and Tomašič, T. (2021). Molecular Dynamics-Derived Pharmacophore Model Explaining the Nonselective Aspect of KV10.1 Pore Blockers. International Journal of Molecular Sciences 22. 10.3390/ijms22168999.

Vieira, A.M., Zahed, F., Crispim, A.C., de Souza Bento, E., França, R.d.F.O., Pinheiro, I.O., Pardo, L.A., and Carvalho, B.M. (2021). Production of levan from Bacillus subtilis var. natto and apoptotic effect on SH-SY5Y neuroblastoma cells. Carbohydrate polymers 273. 10.1016/j.carbpol.2021.118613.



Barros, F., de la Pena, P., Dominguez, P., Sierra, L.M., and Pardo, L.A. (2020). The EAG Voltage-Dependent K(+) Channel Subfamily: Similarities and Differences in Structural Organization and Gating. Front Pharmacol 11, 411. 10.3389/fphar.2020.00411.

Hartung, F., Krüwel, T., Shi, X., Pfizenmaier, K., Kontermann, R., Chames, P., Alves, F., and Pardo, L.A. (2020). A Novel Anti-Kv10.1 Nanobody Fused to Single-Chain TRAIL Enhances Apoptosis Induction in Cancer Cells. Frontiers in Pharmacology 11, 686. 10.3389/fphar.2020.00686.

Hernandez-Resendiz, I., Pacheu-Grau, D., Sanchez, A., and Pardo, L.A. (2020). Inhibition of Kv10.1 Channels Sensitizes Mitochondria of Cancer Cells to Antimetabolic Agents. Cancers (Basel) 12. 10.3390/cancers12040920.

Lazarov, E., Hillebrand, M., Schröder, S., Ternka, K., Hofhuis, J., Ohlenbusch, A., Barrantes-Freer, A., Pardo, L.A., Fruergaard, M.U., Nissen, P., et al. (2020). Comparative analysis of alternating hemiplegia of childhood and rapid-onset dystonia-parkinsonism ATP1A3 mutations reveals functional deficits, which do not correlate with disease severity. Neurobiology of Disease 143, 105012.

Movsisyan, N., and Pardo, L.A. (2020). Kv10.1 Regulates Microtubule Dynamics during Mitosis. Cancers (Basel) 12. 10.3390/cancers12092409.



Barros, F., Pardo, L., Domínguez, P., Sierra, L., and de la Peña, P. (2019). New Structures and Gating of Voltage-Dependent Potassium (Kv) Channels and Their Relatives: A Multi-Domain and Dynamic Question. International Journal of Molecular Sciences 20, 248. 10.3390/ijms20020248.

Ghazaryan, N., Movsisyan, N., Macedo, J.C., Vaz, S., Ayvazyan, N., Pardo, L., and Logarinho, E. (2019). The antitumor efficacy of monomeric disintegrin obtustatin in S-180 sarcoma mouse model. Invest New Drugs 37, 1044-1051. 10.1007/s10637-019-00734-2.

Hernandez-Resendiz, I., Hartung, F., and Pardo, L.A. (2019). Antibodies Targeting KV Potassium Channels: A Promising Treatment for Cancer. Bioelectricity 1, 180-187. 10.1089/bioe.2019.0022.

Movsisyan, N., and Pardo, L.A. (2019). Measurement of Microtubule Dynamics by Spinning Disk Microscopy in Monopolar Mitotic Spindles. Journal of Visualized Experiments. 10.3791/60478.



Cázares-Ordoñez, V., and Pardo, L.A. (2017). Kv10.1 potassium channel: from the brain to the tumors. Biochem. Cell Biol. 95, 531-536. 10.1139/bcb-2017-0062.

Gomez-Lagunas, F., Carrillo, E., Pardo, L.A., and Stuhmer, W. (2017). Gating Modulation of the Tumor-Related Kv10.1 Channel by Mibefradil. J Cell Physiol 232, 2019-2032. 10.1002/jcp.25448.

Moreels, L., Bhat, C., Voráčová, M., Peigneur, S., Goovaerts, H., Mäki-Lohiluoma, E., Zahed, F., Pardo, L.A., Yli-Kauhaluoma, J., Kiuru, P., and Tytgat, J. (2017). Synthesis of novel purpurealidin analogs and evaluation of their effect on the cancer-relevant potassium channel KV10.1. PloS one 12, e0188811. 10.1371/journal.pone.0188811.

Moreels, L., Peigneur, S., Galan, D., De Pauw, E., Béress, L., Waelkens, E., Pardo, L., Quinton, L., and Tytgat, J. (2017). APETx4, a Novel Sea Anemone Toxin and a Modulator of the Cancer-Relevant Potassium Channel KV10.1. Mar. Drugs 15, 287.

Pedersen, S.F., Novak, I., Alves, F., Schwab, A., and Pardo , L.A. (2017). Alternating pH landscapes shape epithelial cancer initiation and progression: focus on pancreatic cancer. Bioessays 39, 201600253-n/a. 10.1002/bies.201600253.

Tomczak, A.P., Fernández-Trillo, J., Bharill, S., Papp, F., Panyi, G., Stühmer, W., Isacoff, E.Y., and Pardo, L.A. (2017). A new mechanism of voltage-dependent gating exposed by K<sub>V</sub>10.1 channels interrupted between voltage sensor and pore. J Gen Physiol. 149, 577-593. 10.1085/jgp.201611742.

Urrego, D., Sánchez, A., Tomczak, A.P., and Pardo, L.A. (2017). The electric fence to cell-cycle progression: Do local changes in membrane potential facilitate disassembly of the primary cilium? Bioessays, 1600190-n/a, 1600190. 10.1002/bies.201600190.



Djamgoz, M.B.A., and Pardo, L.A. (2016). Ion channels, transporters and cancer (“INCA2015”): an international meeting in honor of Prof. Dr. Walter Stühmer. Eur. Biophys. J., 1-3. 10.1007/s00249-016-1153-y.

Hartung, F., and Pardo, L.A. (2016). Guiding TRAIL to cancer cells through Kv10.1 potassium channel overcomes resistance to doxorubicin. Eur. Biophys. J. 45, 709-719. 10.1007/s00249-016-1149-7.

Martin, S., Lazzarini, M., Dullin, C., Balakrishnan, S., Gomes, F.V., Ninkovic, M., Hady, A., Pardo, L.A., Stühmer, W., and Del-Bel, E. (2016). SK3 Channel Overexpression in Mice Causes Hippocampal Shrinkage Associated with Cognitive Impairments. Mol. Neurobiol., 1-14. 10.1007/s12035-015-9680-6.

Napp, J., Pardo, L.A., Hartung, F., Tietze, L.F., Stühmer, W., and Alves, F. (2016). In vivo imaging of tumour xenografts with an antibody targeting the potassium channel Kv10.1. Eur. Biophys. J., 1-13. 10.1007/s00249-016-1152-z.

Ouadid-Ahidouch, H., Ahidouch, A., and Pardo, L.A. (2016). Kv10.1 K+ channel: from physiology to cancer. Pflugers Archiv-European Journal of Physiology 468, 751-762. 10.1007/s00424-015-1784-3.

Sánchez, A., Urrego, D., and Pardo, L.A. (2016). Cyclic expression of the voltage‐gated potassium channel KV10.1 promotes disassembly of the primary cilium. EMBO reports 17, 708-723. 10.15252/embr.201541082.

Urrego, D., Movsisyan, N., Ufartes, R., and Pardo, L.A. (2016). Periodic expression of Kv10.1 driven by pRb/E2F1 contributes to G2/M progression of cancer and non-transformed cells. Cell cycle 15, 799-811. 10.1080/15384101.2016.1138187.



Barrantes-Freer, A., Renovanz, M., Eich, M., Braukmann, A., Sprang, B., Spirin, P., Pardo, L.A., Giese, A., and Kim, E.L. (2015). CD133 Expression Is Not Synonymous to Immunoreactivity for AC133 and Fluctuates throughout the Cell Cycle in Glioma Stem-Like Cells. PloS one 10, e0130519. 10.1371/journal.pone.0130519.

Gomes, F.R., Romaniello, V., Sanchez, A., Weber, C., Narayanan, P., Psol, M., and Pardo, L.A. (2015). Alternatively Spliced Isoforms of K(V)10.1 Potassium Channels Modulate Channel Properties and Can Activate Cyclin-dependent Kinase in Xenopus Oocytes. J. Biol. Chem. 290, 30351-30365. 10.1074/jbc.M115.668749.

Lörinczi, É., Gómez-Posada, J.C., de la Peña, P., Tomczak, A.P., Fernández-Trillo, J., Leipscher, U., Stühmer, W., Barros, F., and Pardo, L.A. (2015). Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains. Nat Commun 6, 6672. 10.1038/ncomms7672.

Martínez, R., Stühmer, W., Martin, S., Schell, J., Reichmann, A., Rohde, V., and Pardo, L. (2015). Analysis of the expression of Kv10.1 potassium channel in patients with brain metastases and glioblastoma multiforme: impact on survival. BMC Cancer 15, 1-9. 10.1186/s12885-015-1848-y.

Mortensen, L.S., Schmidt, H., Farsi, Z., Barrantes-Freer, A., Rubio, M.E., Ufartes, R., Eilers, J., Sakaba, T., Stuehmer, W., and Pardo, L.A. (2015). Kv10.1 opposes activity-dependent increase in Ca2+ influx into the presynaptic terminal of the parallel fibre-Purkinje cell synapse. The Journal of physiology 593, 181-196. 10.1113/jphysiol.2014.281600.



Barrantes-freer, A., Mortensen, L.S., Lohrberg, M., Götz, A., Hanisch, U.-k., Pardo, L.A., Brück, W., and Stadelmann-nessler, C. (2014). MyD88 signaling mediates the effects of the innate immune response in cerebellar short-term synaptic plasticity. J. Neuroimmunol. 275, 95. 10.1016/j.jneuroim.2014.08.255.

Hammer, C., Stepniak, B., Schneider, A., Papiol, S., Tantra, M., Begemann, M., Siren, A.L., Pardo, L.A., Sperling, S., Mohd Jofrry, S., et al. (2014). Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity. Mol. Psychiatry 19, 1143-1149. 10.1038/mp.2013.110.

Issy, A.C., Fonseca, J.R., Pardo, L.A., Stuhmer, W., and Del Bel, E.A. (2014). Hippocampal ether-a-go-go1 potassium channels blockade: effects in the startle reflex and prepulse inhibition. Neurosci. Lett. 559, 13-17. 10.1016/j.neulet.2013.11.026.

Jimenez-Garduno, A.M., Mitkovski, M., Alexopoulos, I.K., Sanchez, A., Stuhmer, W., Pardo, L.A., and Ortega, A. (2014). KV10.1 K(+)-channel plasma membrane discrete domain partitioning and its functional correlation in neurons. Biochim Biophys Acta 1838, 921-931. 10.1016/j.bbamem.2013.11.007.

Pardo, L.A., and Stühmer, W. (2014). The roles of K+ channels in cancer. Nat. Rev. Cancer 14, 39-48. 10.1038/nrc3635.

Urrego, D., Tomczak, A.P., Zahed, F., Stühmer, W., and Pardo, L.A. (2014). Potassium channels in cell cycle and cell proliferation. Philosophical Transactions of the Royal Society B: Biological Sciences 369, 20130094. 10.1098/rstb.2013.0094



Barrantes-Freer, A., Kim, E., Bielanska, J., Giese, A., Mortensen, L.S., Schulz-Schaeffer, W.J., Stadelmann, C., Bruck, W., and Pardo, L.A. (2013). Human glioma-initiating cells show a distinct immature phenotype resembling but not identical to NG2 glia. J. Neuropathol. Exp. Neurol. 72, 307-324. 10.1097/NEN.0b013e31828afdbd.

Cunha, L.C., Del Bel, E., Pardo, L., Stuhmer, W., and R., T.d.A. (2013). RNA interference with EAG1 enhances interferon gamma injury to glioma cells in vitro. Anticancer Res. 33, 865-870.

Herrmann, S., Ninkovic, M., Kohl, T., and Pardo, L.A. (2013). PIST (GOPC) modulates the oncogenic voltage-gated potassium channel KV10.1. Front Physiol 4, 201. 10.3389/fphys.2013.00201.

Ufartes, R., Schneider, T., Mortensen, L.S., de Juan Romero, C., Hentrich, K., Knoetgen, H., Beilinson, V., Moebius, W., Tarabykin, V., Alves, F., et al. (2013). Behavioural and functional characterization of Kv10.1 (Eag1) knockout mice. Hum. Mol. Genet. 22, 2247-2262. 10.1093/hmg/ddt076.



de Oliveira, R.M.W., Martin, S., de Oliveira, C.L., Milani, H., Schiavon, A.P., Joca, S., Pardo, L.A., Stühmer, W., and Del Bel, E.A. (2012). Eag1, Eag2, and SK3 potassium channel expression in the rat hippocampus after global transient brain ischemia. J. Neurosci. Res. 90, 632-640. 10.1002/jnr.22772.

de Queiroz, F.M., Sanchez, A., Agarwal, J.R., Stuhmer, W., and Pardo, L.A. (2012). Nucleofection induces non-specific changes in the metabolic activity of transfected cells. Mol. Biol. Rep. 39, 2187-2194. 10.1007/s11033-011-0967-z.

Ferreira, N.R., Mitkovski, M., Stuhmer, W., Pardo, L.A., and Del Bel, E.A. (2012). Ether-a-go-go 1 (Eag1) potassium channel expression in dopaminergic neurons of basal ganglia is modulated by 6-hydroxydopamine lesion. Neurotox Res 21, 317-333. 10.1007/s12640-011-9286-3.

Herrmann, S., Ninkovic, M., Kohl, T., Lörinczi, E., and Pardo, L.A. (2012). Cortactin controls surface expression of the voltage-gated potassium channel KV10.1. J. Biol. Chem. 287, 44151-44163. 10.1074/jbc.M112.372540.

Menendez, S.T., Villaronga, M.A., Rodrigo, J.P., Alvarez-Teijeiro, S., Garcia-Carracedo, D., Urdinguio, R.G., Fraga, M.F., Pardo, L.A., Viloria, C.G., Suarez, C., and Garcia-Pedrero, J.M. (2012). Frequent aberrant expression of the human ether à go-go (hEAG1) potassium channel in head and neck cancer: pathobiological mechanisms and clinical implications. J Mol Med (Berl) 90, 1173-1184. 10.1007/s00109-012-0893-0.

Ninkovic, M., Mitkovski, M., Kohl, T., Stühmer, W., and Pardo, L.A. (2012). Physical and functional interaction of KV10.1 with Rabaptin-5 impacts ion channel trafficking. FEBS Lett. 586, 3077-3084. 10.1016/j.febslet.2012.07.055.

Pardo, L.A., Gomez-Varela, D., Major, F., Sansuk, K., Leurs, R., Downie, B.R., Tietze, L.F., and Stuhmer, W. (2012). Approaches targeting K(V)10.1 open a novel window for cancer diagnosis and therapy. Curr. Med. Chem. 19, 675-682.

Torres, M.A.V., Menendez, S.T., Rodrigo, J.P., Alvarez-Teijeiro, S., Garcia-Carracedo, D., Urdinguio, R.G., Fraga, M.F., Pardo, L.A., Suarez, C., and Garcia-Pedrero, J.M. (2012). Frequent Aberrant Expression of the Human Ether a Go-go (hEAG1) Potassium Channel in Head and Neck Cancer - Pathobiological Mechanisms and Clinical Implications. Eur. J. Cancer 48, S191. 10.1016/S0959-8049(12)71434-X.



Chen, Y., Sánchez, A., Rubio, M.E., Kohl, T., Pardo, L.A., and Stühmer, W. (2011). Functional Kv10.1 Channels Localize to the Inner Nuclear Membrane. PloS one 6, e19257. 10.1371/journal.pone.0019257.

Grube, S., Gerchen, M.F., Adamcio, B., Pardo, L.A., Martin, S., Malzahn, D., Papiol, S., Begemann, M., Ribbe, K., Friedrichs, H., et al. (2011). A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia. EMBO molecular medicine 3, 309-319. 10.1002/emmm.201100135.

Hartung, F., Stuhmer, W., and Pardo, L.A. (2011). Tumor cell-selective apoptosis induction through targeting of K(V)10.1 via bifunctional TRAIL antibody. Mol Cancer 10, 109. 10.1186/1476-4598-10-109.

Jimenez-Garduno, A.M., Pardo, L.A., Ortega, A., and Stuhmer, W. (2011). Effect of cholesterol and cytoskeleton on K(V)10.1 membrane distribution. European Biophysics Journal with Biophysics Letters 40, 168-169.

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