Publications of Tiago F. Outeiro

Journal Article (60)

41.
Journal Article
Szegö, É. M.; Gerhardt, E.; Outeiro, T. F.: Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3β/β-catenin pathway. Neurobiology of Aging 56, pp. 7 - 16 (2017)
42.
Journal Article
Pardo, J.; Abba , M. C.; Lacunza, E.; Ogundele, O. M.; Paiva, I.; Morel, G. R.; Outeiro, T. F.; Goya, R. G.: IGF-I gene therapy in aging rats modulates hippocampal genes relevant to memory function. Journals of Gerontology: Series A, Biological Sciences and Medical Sciences 73 (4), pp. 459 - 467 (2017)
43.
Journal Article
Paiva, I.; Pinho, R.; Pavlou, M. A.; Hennion, M.; Wales, P.; Schütz, A.-L.; Rajput, A.; Szegö, É. M.; Kerimoglu, C.; Gerhardt, E. et al.; Rego, A. C.; Fischer, A.; Bonn, S.; Outeiro, T. F.: Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage. Human Molecular Genetics 26 (12), pp. 2231 - 2246 (2017)
44.
Journal Article
Turriani, E.; Lázaro, D. F.; Ryazanov, S.; Leonov, A.; Giese, A.; Schön, M.; Schön, M. P.; Griesinger, C.; Outeiro, T. F.; Arndt-Jovin, D. et al.; Becker, D.: Treatment with diphenyl-pyrazole compound anle138b/c reveals that alpha-synuclein protects melanoma cells from autophagic cell death. Proceedings of the National Academy of Sciences of the United States of America 114 (25), pp. E4971 - E4977 (2017)
45.
Journal Article
Miranda, H. V.; Szegö, É. M.; Oliveira, L. M. A.; Breda, C.; Darendelioglu, E.; Oliveira, R. M. d.; Ferreira, D. G.; Gomes, M. A.; Rott, R.; Oliveira, M. et al.; Munari, F.; Enguita, F. J.; Simões, T.; Rodrigues, E. F.; Heinrich, M.; Martins, I. C.; Zamolo, I.; Riess, O.; Cordeiro, C.; Ponces-Freire, A.; Lashuel, H. A.; Santos, N. C.; Lopes, L. V.; Xiang, W.; Jovin, T. M.; Penque, D.; Engelender, S.; Zweckstetter, M.; Klucken, J.; Giorgini, F.; Quintas, A.; Outeiro, T. F.: Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies. Brain 140, pp. 1399 - 1419 (2017)
46.
Journal Article
Pavlou, M. A. S.; Pinho, R.; Paiva, I.; Outeiro, T. F.: The yin and yang of α-synuclein-associated epigenetics in Parkinson's disease. Brain 140, pp. 878 - 886 (2017)
47.
Journal Article
Machado de Oliveira, R.; Miranda, H. V.; Francelle, L.; Pinho, R.; Szegö, É. M.; Martinho, R.; Munari, F.; Lázaro, D. F.; Moniot, S.; Guerreiro, P. et al.; Fonseca, L.; Marijanovic, Z.; Antas, P.; Gerhardt, E.; Enguita, F. J.; Fauvet, B.; Penque, D.; Pais, T. F.; Tong, Q.; Becker, S.; Kügler, S.; Lashuel, H. A.; Steegborn, C.; Zweckstetter, M.; Outeiro, T. F.: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. PLoS Biology 15 (3), e1002601 (2017)
48.
Journal Article
Menges, S.; Minakaki, G.; Schaefer, P. M.; Meixner, H.; Prots, I.; Schlötzer-Schrehardt, U.; Friedland, K.; Winner, B.; Outeiro, T. F.; Winklhofer, K. F. et al.; von Arnim, C. A. F.; Xiang, W.; Winkler, J.; Klucken, J.: Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress. Scientific Reports 7, 42942 (2017)
49.
Journal Article
Branco-Santos, J.; Herrera, F.; Poças, G. M.; Pires-Afonso, Y.; Giorgini, F.; Domingos, P. M.; Outeiro, T. F.: Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity. Human Molecular Genetics 26 (19), pp. 3763 - 3775 (2017)
50.
Journal Article
Gustafsson, G.; Eriksson, F.; Möller, C.; Lopes da Fonseca, T.; Outeiro, T. F.; Lannfelt, L.; Bergström, J.; Ingelsson, M.: Cellular uptake of α-Synuclein oligomer-selective antibodies is enhanced by the extracellular presence of α-Synuclein and mediated via Fcγ receptors. Cellular and Molecular Neurobiology 37, pp. 121 - 131 (2017)
51.
Journal Article
López-León, M.; Outeiro, T. F.; Goya, R. G.: Cell reprogramming: Therapeutic potential and the promise of rejuvenation for the aging brain. Ageing Research Reviews 40, pp. 168 - 181 (2017)
52.
Journal Article
Lázaro, D. F.; Castro Dias, M.; Carija, A.; Navarro, S.; Silva Madaleno, C.; Tenreiro, S.; Ventura, S.; Outeiro, T. F.: The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation. Acta neuropathologica communications 4, 128 (2016)
53.
Journal Article
Miranda, H. V.; Gomes, M. A.; Branco-Santos, J.; Breda, C.; Lázaro, D. F.; Vaqueiro Lopes, L.; Herrera, F.; Giorgini, F.; Outeiro, T. F.: Glycation potentiates neurodegeneration in models of Huntington's disease. Scientific Reports 6, 36798 (2016)
54.
Journal Article
Villar-Piqué, A.; Lopes da Fonseca, T.; Sant'Anna, R.; Szegö, É. M.; Fonseca-Ornelas, L.; Pinho, R.; Carija, A.; Gerhardt, E.; Masaracchia, C.; Gonzalez, E. A. et al.; Rossetti, G.; Carloni, P.; Fernández, C. O.; Foguel, D.; Milosevic, I.; Zweckstetter, M.; Ventura, S.; Outeiro, T. F.: Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity. Proceedings of the National Academy of Sciences of the United States of America 113 (42), pp. E6506 - E6515 (2016)
55.
Journal Article
Batalha, V. L.; Ferreira, D. G.; Coelho, J. E.; Valadas, J. S.; Gomes, R.; Temido-Ferreira, M.; Shmidt, T.; Baqi, Y.; Buée, L.; Müller, C. E. et al.; Hamdane, M.; Outeiro, T. F.; Bader, M.; Meijsing, S.; Sadri-Vakili, G.; Blum, D.; Lopes, L. V.: The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function. Scientific Reports 6, 31493 (2016)
56.
Journal Article
Lopes da Fonseca, T.; Pinho, R.; Outeiro, T. F.: A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death. Human Molecular Genetics 25 (14), pp. 2959 - 2971 (2016)
57.
Journal Article
Letra-Vilela, R.; Sánchez-Sánchez, A. M.; Rocha, A. M.; Martin, V.; Branco-Santos, J.; Puente-Moncada, N.; Santa-Marta, M.; Outeiro, T. F.; Antolín, I.; Rodriguez, C. et al.; Herrera, F.: Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin. Molecular and Cellular Endocrinology 434 (C), pp. 238 - 249 (2016)
58.
Journal Article
Kleinknecht, A.; Popova, B.; Lázaro, D. F.; Pinho, R.; Valerius, O.; Outeiro, T. F.; Braus, G. H.: C-terminal tyrosine residue modifications modulate the protective phosphorylation of Serine 129 of α-synuclein in a yeast model of Parkinson's disease. PLoS Genetics 12 (6), e1006098 (2016)
59.
Journal Article
Miranda, H. V.; El-Agnaf, O. M. A.; Outeiro, T. F.: Glycation in Parkinson's disease and Alzheimer's disease. Movement Disorders 31 (6), pp. 782 - 790 (2016)
60.
Journal Article
Goncalves, S. A.; Macedo, D.; Raquel, H.; Simões, P. D.; Giorgini, F.; Ramalho, J. S.; Barral, D. C.; Moita, L. F.; Outeiro, T. F.: shRNA-based screen identifiers endocytic recycling pathway components that act as genetic modifiers of alpha-synuclein aggregation, secretion and toxicity. PLoS Genetics 12, e1005995 (2016)
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