Publications of Gesine Saher

Depp, C.; Sun, T.; Sasmita, A. O.; Spieth, L.; Berghoff, S. A.; Nazarenko, T.; Overhoff, K.; Steixner-Kumar, A. A.; Subramanian, S.; Arinrad, S. et al.; Ruhwedel, T.; Möbius, W.; Göbbels, S.; Saher, G.; Werner, H. B.; Damkou, A.; Zampar, S.; Wirths, O.; Thalmann, M.; Simons, M.; Saito, T.; Saido, T.; Krueger-Burg, D.; Kawaguchi, R.; Willem, M.; Haass, C.; Geschwind, D.; Ehrenreich, H.; Stassart, R. M.; Nave, K.-A.: Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease. Nature, in press (2023)

Lutomska, L. M.; Miok, V.; Krahmer, N.; García, I. G.; Gruber, T.; Le Thuc, O.; Murat, C. D.; Legutko, B.; Sterr, M.; Saher, G. et al.; Lickert, H.; Müller, T. D.; Ussar, S.; Tschöp, M. H.; Lutter, D.; García-Cáceres, C.: Diet triggers specific responses of hypothalamic astrocytes in time and region dependent manner. Glia 70 (11), pp. 2062 - 2078 (2022)

Düking, T.; Spieth, L.; Berghoff, S. A.; Piepkorn, L.; Schmidke, A. M.; Mitkovski, M.; Kannaiyan, N.; Hosang, L.; Scholz, P.; Shaib, A. H. et al.; Schneider, L. V.; Hesse, D.; Ruhwedel, T.; Sun, T.; Linhoff, L.; Trevisiol, A.; Köhler, S.; Pastor, A. M.; Misgeld, T.; Sereda, M.; Hassouna, I.; Rossner, M. J.; Odoardi, F.; Ischebeck, T.; de Hoz, L.; Hirrlinger, J.; Jahn, O.; Saher, G.: Ketogenic diet uncovers differential metabolic plasticity of brain cells. Science Advances 8 (37), eabo7639 (2022)

Berghoff, S. A.; Spieth, L.; Saher, G.: Local cholesterol metabolism orchestrates remyelination. Trends in Neurosciences 45 (4), pp. 272 - 283 (2022)

Berghoff, S. A.; Spieth, L.; Sun, T.; Hosang, L.; Depp, C.; Sasmita, A. O.; Vasileva, M. H.; Scholz, P.; Zhao, Y.; Krüger, D. et al.; Wichert, S.; Brown, E. R.; Michail, K.; Nave, K.-A.; Bonn, S.; Odoardi, F.; Rossner, M.; Ischebeck, T.; Edgar, J. M.; Saher, G.: Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice. Cell Reports 37 (4), 109889 (2021)

Spieth, L.; Berghoff, S. A.; Stumpf, S. K.; Winchenbach, J.; Michaelis, T.; Watanabe, T.; Gerndt, N.; Düking, T.; Hofer, S.; Ruhwedel, T. et al.; Shaib, A. H.; Willig, K. I.; Kronenberg, K.; Karst, U.; Frahm, J.; Rhee, J. S.; Minguet, S.; Möbius, W.; Kruse, N.; von der Brelie, C.; Michels, P.; Stadelmann, C.; Hülper, P.; Saher, G.: Anesthesia triggers drug delivery to experimental glioma in mice by hijacking caveolar transport. Neuro-Oncology Advances 3 (1), vdab140 (2021)

Berghoff, S. A.; Spieth, L.; Sun, T.; Hosang, L.; Schlaphoff, L.; Depp, C.; Düking, T.; Winchenbach, J.; Neuber, J.; Ewers, D. et al.; Scholz, P.; van der Meer, F.; Cantuti-Castelvetri, L.; Sasmita, A. O.; Meschkat, M.; Ruhwedel, T.; Möbius, W.; Sankowski, R.; Prinz, M.; Huitinga, I.; Sereda, M. W.; Odoardi, F.; Ischebeck, T.; Simons, M.; Stadelmann-Nessler, C.; Edgar, J. M.; Nave, K.-A.; Saher, G.: Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis. Nature Neuroscience 24, pp. 47 - 60 (2021)

Luo, L.; Ambrozkiewicz, M.; Benseler, F.; Chen, C.; Dumontier, E.; Falkner, S.; Furlanis, E.; Gomez, A. M.; Hoshina, N.; Huang, W.-H. et al.; Hutchison, M. A.; Itoh-Maruoka, Y.; Lavery, L. A.; Li, W.; Maruo, T.; Motohashi, J.; Pai, E. L.-L.; Pelkey, K. A.; Pereira, A.; Philips, T.; Sinclair, J. L.; Stogsdill, J. A.; Traunmüller, L.; Wang, J.; Wortel, J.; You, W.; Abumaria, N.; Beier, K. T.; Brose, N.; Burgess, H. A.; Cepko, C. L.; Cloutier, J.-F.; Eroglu, C.; Goebbels, S.; Kaeser, P. S.; Kay, J. N.; Lu, W.; Luo, L.; Mandai, K.; McBain, C. J.; Nave, K.-A.; Prado, M. A.M.; Prado, V. F.; Rothstein, J.; Rubenstein, J. L.R.; Saher, G.; Sakimura, K.; Sanes, J. R.; Scheiffele, P.; Takai, Y.; Umemori, H.; Verhage, M.; Yuzaki, M.; Zoghbi, H. Y.; Kawabe, H.; Craig, A. M.: Optimizing nervous system-specific gene targeting with Cre driver lines: prevalence of germline recombination and influencing factors. Neuron 106 (1), pp. 37 - 65.e5 (2020)

Kalinin, S.; Meares, G. P.; Lin, S. X.; Pietruczyk, E. A.; Saher, G.; Spieth, L.; Nave, K.-A.; Boullerne, A. I.; Lutz, S. E.; Benveniste, E. N. et al.; Feinstein, D. L.: Liver kinase B1 depletion from astrocytes worsens disease in a mouse model of multiple sclerosis. Glia 68 (3), pp. 600 - 616 (2020)

Rosiewicz, K. S.; Crowley, T.; Saher, G.; Kerkering, J.; Alisch, M.; Siffrin, V.: Comparison of RNA isolation procedures for analysis of adult murine brain and spinal cord astrocytes. Journal of Neuroscience Methods 333, 108545 (2020)

Pan, H.; Oliveira, B.; Saher, G.; Dere, E.; Tapken, D.; Mitjans, M.; Seidel, J.; Wesolowski, J.; Wakhloo, D.; Klein-Schmidt, C. et al.; Ronnenberg, A.; Schwabe, K.; Trippe, R.; Mätz-Rensing, K.; Berghoff, S. A.; Al-Krinawe, Y.; Martens, H.; Begemann, M.; Stöcker, W.; Kaup, F.-J.; Mischke, R.; Boretius, S.; Nave, K.-A.; Krauss, J. K.; Hollmann, M.; Lühder, F.; Ehrenreich, H.: Uncoupling the widespread occurrence of anti-NMDAR1 autoantibodies from neuropsychiatric disease in a novel autoimmune model. Molecular Psychiatry 24 (10), pp. 1489 - 1501 (2019)

Stumpf, S. K.; Berghoff, S. A.; Trevisiol, A.; Spieth, L.; Düking, T.; Schneider, L. V.; Schlaphoff, L.; Dreha-Kulaczewski, S.; Bley, A.; Burfeind, D. et al.; Kusch, K.; Mitkovski, M.; Ruhwedel, T.; Guder, P.; Röhse, H.; Denecke, J.; Gärtner, J.; Möbius, W.; Nave, K.-A.; Saher, G.: Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus-Merzbacher disease. Acta Neuropathologica 138, pp. 147 - 161 (2019)

Berghoff, S. A.; Düking, T.; Spieth, L.; Winchenbach, J.; Stumpf, S. K.; Gerndt, N.; Kusch, K.; Ruhwedel, T.; Möbius, W.; Saher, G.: Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model. Acta Neuropathologica Communications 5, 94 (2017)

Berghoff, S. A.; Gerndt, N.; Winchenbach, J.; Stumpf, S. K.; Hosang, L.; Odoardi, F.; Ruhwedel, T.; Böhler, C.; Barrette, B.; Stassart, R. et al.; Liebetanz, D.; Dibaj, P.; Möbius, W.; Edgar, J. M.; Saher, G.: Dietary cholesterol promotes repair of demyelinated lesions in the adult brain. Nature Communications 8, 14241 (2017)

Winchenbach, J.; Düking, T.; Berghoff, S. A.; Stumpf, S. K.; Hülsmann, S.; Nave, K.-A.; Saher, G.: Inducible targeting of CNS astrocytes in Aldh1/1-CreERT2 BAC transgenic mice. Faculty of 1000 Research 5, 2934 (2016)

Winchenbach, J.; Düking, T.; Berghoff, S. A.; Stumpf, S. K.; Hülsmann, S.; Nave, K.-A.; Saher, G.: Inducible targeting of CNS astrocytes in Aldh1l1-CreERT2 BAC transgenic mice. F1000Research 5, 2934 (2016)

Saher, G.; Stumpf, S. K.: Cholesterol in myelin biogenesis and hypomyelinating disorders. Biochimica et Biophysica Acta 1851, pp. 1083 - 1094 (2015)

Hammer, C.; Stepniak, B.; Schneider, A.; Papiol, S.; Tantra, M.; Begemann, M.; Sirén, A.-L.; Pardo, L. A.; Sperling, S.; Mohd Jofrry, S. et al.; Gurvich, A.; Jensen, N.; Ostmeier, K.; Lühder, F.; Probst, C.; Martens, H.; Gillis, M.; Saher, G.; Assogna, F.; Spalletta, G.; Stöcker, W.; Schulz, T. F.; Nave, K.-A.; Ehrenreich, H.: Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity. Molecular Psychiatry 19 (10), pp. 1143 - 1149 (2014)

Werner, H. B.; Krämer-Albers, E.-M.; Strenzke, N.; Saher, G.; Tenzer, S.; Ohno-Iwashita, Y.; Monasterio-Schrader, P. d.; Möbius, W.; Moser, T.; Griffiths, I. R. et al.; Nave, K.-A.: A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system. Glia 61 (4), pp. 567 - 586 (2013)

Paul, D.; Hoppe, S.; Saher, G.; Krijnse-Locker, J.; Bartenschlager, R.: Morphological and biochemical characterization of the membranous hepatitis C virus replication compartment. Journal of Virology 87 (19), pp. 10612 - 10627 (2013)