Publikationen von R. Lührmann
Alle Typen
Zeitschriftenartikel (189)
21.
Zeitschriftenartikel
45 (7), S. 4068 - 4080 (2017)
Regulation of Prp43-mediated disassembly of spliceosomes by its cofactors Ntr1 and Ntr2. Nucleic Acids Research 22.
Zeitschriftenartikel
6, e23533 (2017)
Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation. eLife 23.
Zeitschriftenartikel
542 (7641), S. 318 - 323 (2017)
Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature 24.
Zeitschriftenartikel
6, e21510 (2017)
Structural insights into the mechanism of the DEAH-box RNA helicase Prp43. eLife 25.
Zeitschriftenartikel
45 (11), S. 6729 - 6745 (2017)
SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing. Nucleic Acids Research 26.
Zeitschriftenartikel
64 (2), S. 307 - 319 (2016)
Molecular architecture of SF3b and structural consequences of its cancer-related mutations. Molecular Cell 27.
Zeitschriftenartikel
353 (6306), S. 1399 - 1405 (2016)
Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Science 28.
Zeitschriftenartikel
22 (9), S. 1329 - 1337 (2016)
ATPγS stalls splicing after B complex formation but prior to spliceosome activation. RNA 29.
Zeitschriftenartikel
22 (9), S. 1427 - 1440 (2016)
A protein map of the yeast activated spliceosome as obtained by electron microscopy. RNA 30.
Zeitschriftenartikel
7, 11997 (2016)
A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity. Nature Communications 31.
Zeitschriftenartikel
5, e15564 (2016)
The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction. eLife 32.
Zeitschriftenartikel
351 (6280), S. 1416 - 1420 (2016)
Molecular architecture of the human U4/U6.U5 tri-snRNP. Science 33.
Zeitschriftenartikel
13 (3), S. 320 - 330 (2016)
Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways. RNA Biology 34.
Zeitschriftenartikel
22 (2), S. 265 - 277 (2016)
Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome. RNA 35.
Zeitschriftenartikel
72 (2), S. 112 - 120 (2016)
Structural and functional analysis of the RNA helicase Prp43 from the thermophilic eukaryote Chaetomium thermophilum. Acta Crystallographica Section F 36.
Zeitschriftenartikel
59 (22), S. 10190 - 10197 (2016)
Rational design of cyclic peptide inhibitors of U2AF homology motif (UHM) domains to modulate pre-mRNA splicing. Journal of Medicinal Chemistry 37.
Zeitschriftenartikel
29 (24), S. 2576 - 2587 (2015)
The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation. Genes and Development 38.
Zeitschriftenartikel
34 (24), S. 3059 - 3073 (2015)
Protein localisation by electron microscopy reveals the architecture of the yeast spliceosomal B complex. EMBO Journal 39.
Zeitschriftenartikel
11 (9), e1005539 (2015)
Dynamic contacts of U2, RES, Cwc25, Prp8 and Prp45 proteins with the Pre-mRNA branch-site and 3' splice site during catalytic activation and step 1 catalysis in yeast spliceosomes. PLoS Genetics 40.
Zeitschriftenartikel
21 (11), S. 1993 - 2005 (2015)
Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5‘ splice site. RNA