MPI-Nat Seminars: Investigating the roles of adhesion GPCRs in synapse formation and circuit assembly
MPI-Nat Seminars
- Date: Oct 13, 2026
- Time: 02:00 PM - 03:00 PM (Local Time Germany)
- Speaker: Richard Sando
- Vanderbilt University
- Location: Max-Planck-Institut für Multidisziplinäre Naturwissenschaften (MPI-NAT, City-Campus)
- Room: Lecture Hall
- Host: Nils Brose
- Contact: franziska.schmidt@mpinat.mpg.de
Bidirectional trans-synaptic signaling directs synapse formation and neural circuit assembly. Increasing evidence supports that several subfamilies of adhesion G protein-coupled receptors (aGPCRs) control important mechanistic aspects of synapse assembly and neural circuit wiring by combining trans-synaptic adhesion with GPCR signaling. I will discuss the role of aGPCRs in establishing striatal D2 medium spiny neuron circuits, and our recently developed time-lapse imaging approaches to visualize synapse formation.