Publications

Mozaffari-Jovin, S.; Santos, K. F.; Hsiao, H. H.; Will, C. L.; Urlaub, H.; Wahl, M. C.; Lührmann, R.: The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA. Genes and Development 26 (23), pp. 2422 - 2434 (2012)

Schmitzova, J.; Pena, V.: Emerging views about the molecular structure of the spliceosomal catalytic center. RNA Biology 9 (11), pp. 1311 - 1318 (2012)

Santos , K. F.; Mozaffari-Jovin, S.; Weber , G.; Pena, V.; Lührmann, R.; Wahl, M. C.: Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome. Proceedings of the National Academy of Sciences of the United States of America 109 (43), pp. 17418 - 17423 (2012)

Patil, V.; Canzoneri, J. C.; Samatov, T. R.; Lührmann, R.; Oyelere, A. K.: Molecular architecture of Zinc chelating small molecules that inhibit spliceosome assembly at an early stage. RNA 18 (9), pp. 1605 - 1611 (2012)

Simoes-Barbosa, A.; Chakrabarti, K.; Pearson, M. D.; Benarroch, D.; Shuman, S.; Johnson, P. J.: Box H/ACA snoRNAs are preferred substrates for the trimethylguanosine synthase in the divergent unicellular eukaryote Trichomonas vaginalis. RNA 18 (9), pp. 1656 - 1665 (2012)

Girard, C.; Will, C. L.; Peng, J.; Makarov, E. M.; Kastner, B.; Lemm, I.; Urlaub, H.; Hartmuth, K.; Lührmann, R.: Retention of posttranscriptional spliceosomes in nuclear speckles until splicing completion. Nature communications 3, 994 (2012)

Wolf, E.; Kastner, B.; Lührmann, R.: Antisense-targeted immuno-EM localization of the pre-mRNA path in the spliceosomal C complex. RNA 18 (7), pp. 1347 - 1357 (2012)

Rasche, N.; Dybkov, O.; Schmitzova, J.; Akyildiz, B.; Fabrizio, P.; Lührmann, R.: Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre. EMBO Journal 31 (6), pp. 1591 - 1604 (2012)

Samatov, T. R.; Wolf, A.; Odenwälder, P.; Bessonov, S.; Deraeve, C.; Bon, R. S.; Waldmann, H.; Lührmann, R.: Psoromic acid derivatives: A new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay. ChemBioChem 13 (5), pp. 640 - 644 (2012)

Hegele, A.; Kamburov, A.; Grossmann, A.; Sourlis, C.; Wowro, S.; Weimann, M.; Will, C. L.; Pena, V.; Lührmann, R.; Stelzl, U.: Dynamic protein-protein interaction wiring of the human spliceosome. Molecular Cell 45 (4), pp. 567 - 580 (2012)

Ohrt, T.; Prior, M.; Dannenberg, J.; Odenwälder, P.; Dybkov, O.; Rasche, N.; Schmitzova, J.; Gregor, I.; Fabrizio, P.; Enderlein, J. et al.; Lührmann, R.: Prp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS. RNA 18 (6), pp. 1244 - 1256 (2012)

Schmitzova, J.; Rasche, N.; Dybkov, O.; Kramer, K.; Fabrizio, P.; Urlaub, H.; Lührmann, R.; Pena, V.: Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein. EMBO Journal 31 (9), pp. 2222 - 2234 (2012)

Stamm, S.; Smith, C.; Lührmann, R. (Eds.): Alternative pre-mRNA splicing: Theory and protocols. Wiley-VCH, Weinheim (2012), XXXVII, 622 pp.

Fabrizio, P.; Lührmann, R.: The spliceosome in constitutive splicing. In: Alternative pre-mRNA splicing: Theory and protocols, pp. 49 - 64 (Ed. Stamm, S.). Wiley-VCH, Weinheim (2012)

Hartmuth, K.; van Santen, M. A.; Lührmann, R.: Ultracentrifugation in the analysis and purification of spliceosomes assembled In Vitro. In: Alternative pre-mRNA splicing: Theory and protocols, pp. 147 - 153 (Eds. Stamm, S.; Smith, C.; Lührmann, R.). Wiley-VCH, Weinheim (2012)

Hartmuth, K.; van Santen, M. A.; Odenwälder, P.; Lührmann, R.: Assembly and isolation of spliceosomal complexes In Vitro. In: Alternative pre-mRNA splicing: Theory and protocols, pp. 331 - 340 (Eds. Stamm, S.; Smith, C.; Lührmann, R.). Wiley-VCH, Weinheim (2012)

Hartmuth, K.; van Santen, M. A.; Rösel, T.; Kastner, B.; Lührmann, R.: The preparation of HeLa cell nuclear extracts. In: Alternative pre-mRNA splicing: Theory and protocols, pp. 313 - 319 (Eds. Stamm, S.; Smith, C.; Lührmann, R.). Wiley-VCH, Weinheim (2012)