Publikationen (Nave)
(https://scholar.google.com/citations?user=VotFewwAAAAJ&hl=de&oi=ao)
Schaeffner, E., Edgar, J.M., Lehning, M., Strauß, J., Bosch-Queralt, M., Wieghofer, P., Berghoff, S.A., Krueger, M., Morawski, M., Reinert, T., Möbius, W., Barrantes-Freer, A., Prinz, M., Reich, D.S., Flügel, A., Stadelmann, C., Fledrich, R., Stassart, R.M., and Nave, K.-A. (2021). Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease.
bioRxiv. DOI: https://doi.org/10.1101/2021.11.11.468223
Depp, C., Sun, T., Sasmita, A.O., Spieth, L., Berghoff, S.A., Steixner-Kumar, A.A., Subramanian, S., Möbius, W., Goebbels, S., Saher, G., Zampar, S., Wirths, O., Thalmann, M., Saito, T., Saido, T., Krueger-Burg, D., Kawaguchi, R., Willem, M., Haas, C., Geschwind, D., Ehrenreich, H., Stassart, R., and Nave, K.-A. (2021). Ageing-associated myelin dysfunction drives amyloid deposition in mouse models of Alzheimer’s disease.
bioRxiv. DOI: https://doi.org/10.1101/2021.07.31.454562
Berghoff, S.A., Spieth, L., Sun, T., Hosang, L., Schlaphoff, L., Depp, C., Duking, T., Winchenbach, J., Neuber, J., Ewers, D., Scholz, P., van der Meer, F., Cantuti-Castelvetri, L., Sasmita, A.O., Meschkat, M., Ruhwedel, T., Mobius, W., Sankowski, R., Prinz, M., Huitinga, I., Sereda, M.W., Odoardi, F., Ischebeck, T., Simons, M., Stadelmann-Nessler, C., Edgar, J.M., Nave, K.A., and Saher, G. (2021). Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis.
Nat Neurosci 24, 47-60. DOI: 10.1038/s41593-020-00757-6
Trevisiol, A., Kusch, K., Steyer, A.M., Gregor, I., Nardis, C., Winkler, U., Kohler, S., Restrepo, A., Mobius, W., Werner, H.B., Nave, K.A., and Hirrlinger, J. (2020). Structural myelin defects are associated with low axonal ATP levels but rapid recovery from energy deprivation in a mouse model of spastic paraplegia.
PLoS biology 18, e3000943. DOI: 10.1371/journal.pbio.3000943
Moore, S., Meschkat, M., Ruhwedel, T., Trevisiol, A., Tzvetanova, I.D., Battefeld, A., Kusch, K., Kole, M.H.P., Strenzke, N., Mobius, W., de Hoz, L., and Nave, K.A. (2020). A role of oligodendrocytes in information processing.
Nat Commun 11, 5497. DOI: 10.1038/s41467-020-19152-7
Werner, H.B., and Nave, K.A. (2019). Enhanced Actin Dynamics: A Therapeutic Strategy for Axonal Regeneration?
Neuron 103, 949-950. DOI: 10.1016/j.neuron.2019.09.008
Janova, H., Arinrad, S., Balmuth, E., Mitjans, M., Hertel, J., Habes, M., Bittner, R.A., Pan, H., Goebbels, S., Begemann, M., Gerwig, U.C., Langner, S., Werner, H.B., Kittel-Schneider, S., Homuth, G., Davatzikos, C., Volzke, H., West, B.L., Reif, A., Grabe, H.J., Boretius, S., Ehrenreich, H., and Nave, K.A. (2018). Microglia ablation alleviates myelin-associated catatonic signs in mice.
J Clin Invest 128, 734-745. DOI: 10.1172/JCI97032
Trevisiol, A., Saab, A.S., Winkler, U., Marx, G., Imamura, H., Mobius, W., Kusch, K., Nave, K.A., and Hirrlinger, J. (2017). Monitoring ATP dynamics in electrically active white matter tracts.
eLife 6, e24241. DOI: 10.7554/eLife.24241
Snaidero, N., Velte, C., Myllykoski, M., Raasakka, A., Ignatev, A., Werner, H.B., Erwig, M.S., Mobius, W., Kursula, P., Nave, K.A., and Simons, M. (2017). Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin.
Cell Rep 18, 314-323. DOI: 10.1016/j.celrep.2016.12.053
Saab, A.S., and Nave, K.A. (2017). Myelin dynamics: protecting and shaping neuronal functions.
Curr Opin Neurobiol 47, 104-112. DOI: 10.1016/j.conb.2017.09.013
Janova, H., Arinrad, S., Balmuth, E., Mitjans, M., Hertel, J., Habes, M., Bittner, R.A., Pan, H., Goebbels, S., Begemann, M., Gerwig, U.C., Langner, S., Werner, H.B., Kittel-Schneider, S., Homuth, G., Davatzikos, C., Volzke, H., West, B.L., Reif, A., Grabe, H.J., Boretius, S., Ehrenreich, H., and Nave, K.A. (2017). Microglia ablation alleviates myelin-associated catatonic signs in mice.
J Clin Invest 128, 734-745. DOI: 10.1172/JCI97032
Goebbels, S., Wieser, G.L., Pieper, A., Spitzer, S., Weege, B., Yan, K., Edgar, J.M., Yagensky, O., Wichert, S.P., Agarwal, A., Karram, K., Renier, N., Tessier-Lavigne, M., Rossner, M.J., Karadottir, R.T., and Nave, K.A. (2017). A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination.
Nat Neurosci 20, 10-15. DOI: 10.1038/nn.4425
Saab, A.S., Tzvetavona, I.D., Trevisiol, A., Baltan, S., Dibaj, P., Kusch, K., Mobius, W., Goetze, B., Jahn, H.M., Huang, W., Steffens, H., Schomburg, E.D., Perez-Samartin, A., Perez-Cerda, F., Bakhtiari, D., Matute, C., Lowel, S., Griesinger, C., Hirrlinger, J., Kirchhoff, F., and Nave, K.A. (2016). Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism.
Neuron 91, 119-132. DOI: 10.1016/j.neuron.2016.05.016
Quintes, S., Brinkmann, B.G., Ebert, M., Frob, F., Kungl, T., Arlt, F.A., Tarabykin, V., Huylebroeck, D., Meijer, D., Suter, U., Wegner, M., Sereda, M.W., and Nave, K.A. (2016). Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair.
Nat Neurosci 19, 1050-1059. DOI: 10.1038/nn.4321
Simons, M., and Nave, K.A. (2015). Oligodendrocytes: Myelination and Axonal Support.
Cold Spring Harb Perspect Biol 8. DOI: 10.1101/cshperspect.a020479
Snaidero, N., Mobius, W., Czopka, T., Hekking, L.H., Mathisen, C., Verkleij, D., Goebbels, S., Edgar, J., Merkler, D., Lyons, D.A., Nave, K.A., and Simons, M. (2014). Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue.
Cell 156, 277-290. DOI: 10.1016/j.cell.2013.11.044
Nave, K.A., and Werner, H.B. (2014). Myelination of the nervous system: mechanisms and functions.
Ann Rev Cell Dev Biol 30, 503-533. DOI: 10.1146/annurev-cellbio-100913-013101
Nave, K.A., and Ehrenreich, H. (2014). Myelination and oligodendrocyte functions in psychiatric diseases.
JAMA psychiatry 71, 582-584. DOI: 10.1001/jamapsychiatry.2014.189
Mei, L., and Nave, K.A. (2014). Neuregulin-ERBB Signaling in the Nervous System and Neuropsychiatric Diseases.
Neuron 83, 27-49. DOI: 10.1016/j.neuron.2014.06.007
Fledrich, R., Stassart, R.M., Klink, A., Rasch, L.M., Prukop, T., Haag, L., Czesnik, D., Kungl, T., Abdelaal, T.A., Keric, N., Stadelmann, C., Bruck, W., Nave, K.A., and Sereda, M.W. (2014). Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A.
Nat Med 20, 1055-1061. DOI: 10.1038/nm.3664
Stassart, R.M., Fledrich, R., Velanac, V., Brinkmann, B.G., Schwab, M.H., Meijer, D., Sereda, M.W., and Nave, K.A. (2013). A role for Schwann cell-derived neuregulin-1 in remyelination.
Nat Neurosci 16, 48-54. DOI: 10.1038/nn.3281
Saab, A.S., Tzvetanova, I.D., and Nave, K.A. (2013). The role of myelin and oligodendrocytes in axonal energy metabolism.
Curr Opin Neurobiol 23, 1065-1072. DOI: 10.1016/j.conb.2013.09.008
Saher, G., Rudolphi, F., Corthals, K., Ruhwedel, T., Schmidt, K.F., Lowel, S., Dibaj, P., Barrette, B., Mobius, W., and Nave, K.A. (2012). Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet.
Nat Med 18, 1130-1135. DOI: 10.1038/nm.2833
Funfschilling, U., Supplie, L.M., Mahad, D., Boretius, S., Saab, A.S., Edgar, J., Brinkmann, B.G., Kassmann, C.M., Tzvetanova, I.D., Mobius, W., Diaz, F., Meijer, D., Suter, U., Hamprecht, B., Sereda, M.W., Moraes, C.T., Frahm, J., Goebbels, S., and Nave, K.A. (2012). Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity.
Nature 485, 517-521. DOI: 10.1038/nature11007
Nave, K.A. (2010). Myelination and support of axonal integrity by glia.
Nature 468, 244-252. DOI: 10.1038/nature09614
Nave, K.A. (2010). Myelination and the trophic support of long axons.
Nat Rev Neurosci 11, 275-283. DOI: 10.1038/nrn2797
Goebbels, S., Oltrogge, J.H., Kemper, R., Heilmann, I., Bormuth, I., Wolfer, S., Wichert, S.P., Mobius, W., Liu, X., Lappe-Siefke, C., Rossner, M.J., Groszer, M., Suter, U., Frahm, J., Boretius, S., and Nave, K.A. (2010). Elevated phosphatidylinositol 3,4,5-trisphosphate in glia triggers cell-autonomous membrane wrapping and myelination.
J Neurosci 30, 8953-8964. DOI: 10.1523/JNEUROSCI.0219-10.2010
Edgar, J.M., and Nave, K.A. (2009). The role of CNS glia in preserving axon function.
Curr Opin Neurobiol 19, 498-504. DOI: 10.1016/j.conb.2009.08.003
Trapp, B.D., and Nave, K.A. (2008). Multiple sclerosis: an immune or neurodegenerative disorder?
Annu Rev Neurosci 31, 247-269. DOI: 10.1146/annurev.neuro.30.051606.094313
Nave, K.A., and Trapp, B.D. (2008). Axon-glial signaling and the glial support of axon function.
Annu Rev Neurosci 31, 535-561. DOI: 10.1146/annurev.neuro.30.051606.094309
Brinkmann, B.G., Agarwal, A., Sereda, M.W., Garratt, A.N., Muller, T., Wende, H., Stassart, R.M., Nawaz, S., Humml, C., Velanac, V., Radyushkin, K., Goebbels, S., Fischer, T.M., Franklin, R.J., Lai, C., Ehrenreich, H., Birchmeier, C., Schwab, M.H., and Nave, K.A. (2008). Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.
Neuron 59, 581-595. DOI: 10.1016/j.neuron.2008.06.028
Werner, H.B., Kuhlmann, K., Shen, S., Uecker, M., Schardt, A., Dimova, K., Orfaniotou, F., Dhaunchak, A., Brinkmann, B.G., Mobius, W., Guarente, L., Casaccia-Bonnefil, P., Jahn, O., and Nave, K.A. (2007). Proteolipid protein is required for transport of sirtuin 2 into CNS myelin.
J Neurosci 27, 7717-7730. DOI: 10.1523/JNEUROSCI.1254-07.2007
Nave, K.A., Sereda, M.W., and Ehrenreich, H. (2007). Mechanisms of disease: inherited demyelinating neuropathies--from basic to clinical research.
Nat Clin Pract Neurol 3, 453-464. DOI: 10.1038/ncpneuro0583
Kassmann, C.M., Lappe-Siefke, C., Baes, M., Brugger, B., Mildner, A., Werner, H.B., Natt, O., Michaelis, T., Prinz, M., Frahm, J., and Nave, K.A. (2007). Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes.
Nat Genet 39, 969-976. DOI: 10.1038/ng2070
Dhaunchak, A.S., and Nave, K.A. (2007). A common mechanism of PLP/DM20 misfolding causes cysteine-mediated endoplasmic reticulum retention in oligodendrocytes and Pelizaeus-Merzbacher disease.
Proc Natl Acad Sci U S A 104, 17813-17818. DOI: 10.1073/pnas.0704975104
Nave, K.A., and Salzer, J.L. (2006). Axonal regulation of myelination by neuregulin 1.
Curr Opin Neurobiol 16, 492-500. DOI: 10.1016/j.conb.2006.08.008
Meyer Zu Horste, G., and Nave, K.A. (2006). Animal models of inherited neuropathies.
Curr Opin Neurol 19, 464-473. DOI: 10.1097/01.wco.0000245369.44199.27
Kramer-Albers, E.M., Gehrig-Burger, K., Thiele, C., Trotter, J., and Nave, K.A. (2006). Perturbed interactions of mutant proteolipid protein/DM20 with cholesterol and lipid rafts in oligodendroglia: implications for dysmyelination in spastic paraplegia.
J Neurosci 26, 11743-11752. DOI: 10.1523/JNEUROSCI.3581-06.2006
Saher, G., Brugger, B., Lappe-Siefke, C., Mobius, W., Tozawa, R., Wehr, M.C., Wieland, F., Ishibashi, S., and Nave, K.A. (2005). High cholesterol level is essential for myelin membrane growth.
Nat Neurosci 8, 468-475. DOI: 10.1038/nn1426
Michailov, G.V., Sereda, M.W., Brinkmann, B.G., Fischer, T.M., Haug, B., Birchmeier, C., Role, L., Lai, C., Schwab, M.H., and Nave, K.A. (2004). Axonal neuregulin-1 regulates myelin sheath thickness.
Science 304, 700-703. DOI: 10.1126/science.1095862
Sereda, M.W., Meyer zu Horste, G., Suter, U., Uzma, N., and Nave, K.A. (2003). Therapeutic administration of progesterone antagonist in a model of Charcot-Marie-Tooth disease (CMT-1A).
Nat Med 9, 1533-1537. DOI: 10.1038/nm957
Lappe-Siefke, C., Goebbels, S., Gravel, M., Nicksch, E., Lee, J., Braun, P.E., Griffiths, I.R., and Nave, K.A. (2003). Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination.
Nat Genet 33, 366-374. DOI: 10.1038/ng1095
Griffiths, I., Klugmann, M., Anderson, T., Yool, D., Thomson, C., Schwab, M.H., Schneider, A., Zimmermann, F., McCulloch, M., Nadon, N., and Nave, K.A. (1998). Axonal swellings and degeneration in mice lacking the major proteolipid of myelin.
Science 280, 1610-1613. DOI: 10.1126/science.280.5369.1610
Klugmann, M., Schwab, M.H., Puhlhofer, A., Schneider, A., Zimmermann, F., Griffiths, I.R., and Nave, K.A. (1997). Assembly of CNS myelin in the absence of proteolipid protein.
Neuron 18, 59-70. DOI: 10.1016/s0896-6273(01)80046-5
Sereda, M., Griffiths, I., Puhlhofer, A., Stewart, H., Rossner, M.J., Zimmerman, F., Magyar, J.P., Schneider, A., Hund, E., Meinck, H.M., Suter, U., and Nave, K.A. (1996). A transgenic rat model of Charcot-Marie-Tooth disease.
Neuron 16, 1049-1060. DOI: 10.1016/s0896-6273(00)80128-2
Readhead, C., Schneider, A., Griffiths, I., and Nave, K.A. (1994). Premature arrest of myelin formation in transgenic mice with increased proteolipid protein gene dosage.
Neuron 12, 583-595. DOI: 10.1016/0896-6273(94)90214-3
Schneider, A., Montague, P., Griffiths, I., Fanarraga, M., Kennedy, P., Brophy, P., and Nave, K.A. (1992). Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene.
Nature 358, 758-761. DOI: 10.1038/358758a0